{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:53:06Z","timestamp":1784746386898,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["airmedicaljournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Air Medical Journal"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.amj.2022.04.004","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T17:09:21Z","timestamp":1654016961000},"page":"498-502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prehospital Hypertonic Saline Administration After Severe Traumatic Brain Injury"],"prefix":"10.1016","volume":"41","author":[{"given":"Chris","family":"Goddard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"Collopy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Powers IV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amj.2022.04.004_bib0001","unstructured":"Thurman DJ, Alverson C, Browne D, et\u00a0al. Traumatic brain injury in the United States. Centers for Disease Control and Prevention Report to Congress. Available at: https:\/\/www.cdc.gov\/traumaticbraininjury\/pubs\/tbi_report_to_congress.html#:\u223c:text=Incidence%20and%20Prevalence%20of%20Traumatic,million%20Americans%20sustain%20a%20TBI. Accessed 15 July 2021."},{"key":"10.1016\/j.amj.2022.04.004_bib0002","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.injury.2021.01.008","article-title":"Emergency medical services protocols for traumatic brain injury in the United States: a call for standardization","volume":"52","author":"Chuck","year":"2021","journal-title":"Injury"},{"key":"10.1016\/j.amj.2022.04.004_bib0003","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jama.2010.1405","article-title":"Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial","volume":"304","author":"Bulger","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.amj.2022.04.004_bib0004","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","article-title":"Guidelines for the management of severe traumatic brain injury, fourth edition","volume":"80","author":"Carney","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.amj.2022.04.004_bib0005","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/j.injury.2020.08.030","article-title":"Prehospital fluid administration in patients with severe traumatic brain injury: a systematic review and meta-analysis","volume":"51","author":"Bergmans","year":"2020","journal-title":"Injury"},{"key":"10.1016\/j.amj.2022.04.004_bib0006","series-title":"Surveillance report of traumatic brain injury-related hospitalizations and deaths by age group, sex, and mechanism of injury\u2014United States, 2016 and 2017","year":"2021"},{"key":"10.1016\/j.amj.2022.04.004_bib0007","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/1060028016628893","article-title":"Zed PJ. a systematic review of randomized controlled trials comparing hypertonic sodium solutions and mannitol for traumatic brain injury: implications for emergency department management","volume":"50","author":"Burgess","year":"2016","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.amj.2022.04.004_bib0008","series-title":"Mannitol","author":"Tenny","year":"2021"},{"key":"10.1016\/j.amj.2022.04.004_bib0009","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1001\/jama.291.11.1350","article-title":"Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial","volume":"291","author":"Cooper","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.amj.2022.04.004_bib0010","series-title":"Hypertonic Fluids","author":"Mason","year":"2021"},{"key":"10.1016\/j.amj.2022.04.004_bib0011","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jemermed.2018.12.046","article-title":"Safety of peripheral line administration of 3% hypertonic saline and mannitol in the emergency department","volume":"56","author":"Mesghali","year":"2019","journal-title":"J Emerg Med"},{"key":"10.1016\/j.amj.2022.04.004_bib0012","doi-asserted-by":"crossref","first-page":"e21655","DOI":"10.1097\/MD.0000000000021655","article-title":"Hypertonic saline and mannitol in patients with traumatic brain injury: a systematic and meta-analysis","volume":"99","author":"Shi","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.amj.2022.04.004_bib0013","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jocn.2015.08.035","article-title":"An equiosmolar study on early intracranial physiology and long term outcome in severe traumatic brain injury comparing mannitol and hypertonic saline","volume":"27","author":"Jagannatha","year":"2016","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.amj.2022.04.004_bib0014","doi-asserted-by":"crossref","first-page":"e791","DOI":"10.1097\/PEC.0000000000001959","article-title":"Assessing the impact of 3% hypertonic saline hyperosmolar therapy on intubated children with isolated traumatic brain injury by cerebral oximetry in a pediatric emergency setting","volume":"37","author":"Washer","year":"2021","journal-title":"Pediatr Emerg Care"},{"issue":"2","key":"10.1016\/j.amj.2022.04.004_bib0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/neuros\/nyz046","article-title":"Hypertonic saline is superior to mannitol for the combined effect on intracranial pressure and cerebral perfusion pressure burdens in patients with severe traumatic brain injury","volume":"86","author":"Mangat","year":"2020","journal-title":"Neurosurgery"},{"key":"10.1016\/j.amj.2022.04.004_bib0016","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/ANA.0000000000000644","article-title":"Hypertonic saline versus mannitol for traumatic brain injury: a systematic review and meta-analysis with trial sequential analysis","volume":"33","author":"Schwimmbeck","year":"2021","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1016\/j.amj.2022.04.004_bib0017","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/SHK.0000000000000038","article-title":"Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury","volume":"40","author":"Junger","year":"2013","journal-title":"Shock"},{"key":"10.1016\/j.amj.2022.04.004_bib0018","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/PEC.0b013e31827b54c3","article-title":"Intravenous hypertonic saline use in the pediatric emergency department","volume":"29","author":"Brenkert","year":"2013","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.amj.2022.04.004_bib0019","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/PEC.0b013e31823aff59","article-title":"Three-percent saline administration during pediatric critical care transport","volume":"27","author":"Luu","year":"2011","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.amj.2022.04.004_bib0020","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/JNN.0000000000000286","article-title":"Complication rates of 3% hypertonic saline infusion through peripheral intravenous access","volume":"49","author":"Perez","year":"2017","journal-title":"J Neurosci Nurs"}],"container-title":["Air Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1067991X22000748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1067991X22000748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:23:25Z","timestamp":1761024205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1067991X22000748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1067991X22000748"],"URL":"https:\/\/doi.org\/10.1016\/j.amj.2022.04.004","relation":{},"ISSN":["1067-991X"],"issn-type":[{"value":"1067-991X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prehospital Hypertonic Saline Administration After Severe Traumatic Brain Injury","name":"articletitle","label":"Article Title"},{"value":"Air Medical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amj.2022.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Air Medical Journal Associates. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}