{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:34:04Z","timestamp":1790458444946,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.amjcard.2005.01.097","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T11:05:52Z","timestamp":1118574352000},"page":"1420-1424","source":"Crossref","is-referenced-by-count":13,"title":["Family History, Plasma Homocysteine, and Age at Onset of Symptoms of Myocardial Ischemia in Patients With Different Methylenetetrahydrofolate Reductase Genotypes"],"prefix":"10.1016","volume":"95","author":[{"given":"Aviv","family":"Mager","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira","family":"Koren-Morag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai","family":"Shohat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Harell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Battler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2005.01.097_bib1","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1161\/01.CIR.99.16.2144","article-title":"Plasma homocysteine distribution and its association with parental history of coronary artery disease in black and white children. The Bogalusa heart study","volume":"99","author":"Greenlund","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2005.01.097_bib2","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1161\/01.CIR.0000017360.99531.26","article-title":"Plasma homocysteine and parental myocardial infarction in young adults in Jerusalem","volume":"105","author":"Kark","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2005.01.097_bib3","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1161\/01.CIR.85.6.2065","article-title":"Role of family history in patients with myocardial infarction. An Italian case-control study","volume":"85","author":"Roncaglioni","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2005.01.097_bib4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0002-9149(97)00304-4","article-title":"Frequency of family history of acute myocardial infarction in patients with acute myocardial infarction","volume":"80","author":"Ciruzzi","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2005.01.097_bib5","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0735-1097(84)80408-8","article-title":"Family history as an independent risk factor for coronary heart disease","volume":"4","author":"Shea","year":"1984","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2005.01.097_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00001648-200103000-00014","article-title":"Family history of coronary heart disease, a strong risk factor myocardial infarction interacting with other cardiovascular risk factors","volume":"12","author":"Leander","year":"2001","journal-title":"Epidemiology"},{"key":"10.1016\/j.amjcard.2005.01.097_bib7","doi-asserted-by":"crossref","first-page":"11311","DOI":"10.1093\/oxfordjournals.eurheartj.a060059","article-title":"Family history as an independent risk factor for coronary artery disease","volume":"13","author":"Grech","year":"1992","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2005.01.097_bib8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/hrt.53.4.382","article-title":"Family history of myocardial infarction as an independent risk factor for coronary heart disease","volume":"53","author":"Friedlander","year":"1985","journal-title":"Br Heart J"},{"key":"10.1016\/j.amjcard.2005.01.097_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1469-1809.2003.00017.x","article-title":"Second Northwick Park Heart Study. Family history is a coronary heart disease risk factor in the SE Second Northwick Park Heart Study","volume":"67","author":"Hawe","year":"2003","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.amjcard.2005.01.097_bib10","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/0735-1097(90)90542-W","article-title":"Plasma homocyst(e)ine levels in men with premature coronary artery disease","volume":"16","author":"Genest","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2005.01.097_bib11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/ajcn\/59.4.940","article-title":"Plasma homocyst(e)ine, folate and vitamin B-12 concentrations and risk for early-onset coronary artery disease","volume":"59","author":"Pancharuniti","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.amjcard.2005.01.097_bib12","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0002-9149(99)80739-5","article-title":"Homocysteine and coronary artery disease in French Canadian subjects","volume":"75","author":"Dalery","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2005.01.097_bib13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00019501-199910000-00002","article-title":"Plasma homocysteine level and development of coronary artery disease","volume":"10","author":"Kawashiri","year":"1999","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.amjcard.2005.01.097_bib14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.amjcard.2005.01.097_bib15","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1161\/01.CIR.100.24.2406","article-title":"Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease","volume":"100","author":"Mager","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2005.01.097_bib16","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0002-9149(02)02239-7","article-title":"Plasma homocysteine, methylenetetrahydrofolate reductase genotypes and age at onset of symptoms of myocardial ischemia","volume":"89","author":"Mager","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2005.01.097_bib17","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0002-9149(00)01103-6","article-title":"Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia","volume":"86","author":"Kawashiri","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2005.01.097_bib18","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1161\/01.CIR.98.23.2520","article-title":"Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease","volume":"23","author":"Brattstrom","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2005.01.097_bib19","doi-asserted-by":"crossref","unstructured":"McGill HC, McMahan CA, Zieske AW, Malcom GT, Tracy RE, Strong JP, for the Pathophysiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Effects of nonlipid risk factors on atherosclerosis in youth with favorable lipoprotein profile. Circulation 200;103:1546\u20131550.","DOI":"10.1161\/01.CIR.103.11.1546"},{"key":"10.1016\/j.amjcard.2005.01.097_bib20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1067\/mhj.2002.120300","article-title":"Acute myocardial infarction in the young\u2014the University of Michigan experience","volume":"143","author":"Doughty","year":"2002","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2005.01.097_bib21","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/jama.290.7.898","article-title":"Prevalence of conventional risk factors in patients with coronary heart disease","volume":"290","author":"Khot","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2005.01.097_bib22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0735-1097(02)02017-X","article-title":"Contribution of major risk factors to familial premature coronary artery disease. The GENECARD project","volume":"40","author":"Jomini","year":"2002","journal-title":"J Am Coll Cardiol"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914905004649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914905004649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,24]],"date-time":"2019-02-24T12:15:24Z","timestamp":1551010524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914905004649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0002914905004649"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2005.01.097","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}