{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:04Z","timestamp":1791308824428,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.amjcard.2006.03.009","type":"journal-article","created":{"date-parts":[[2006,4,10]],"date-time":"2006-04-10T16:20:11Z","timestamp":1144686011000},"page":"34-40","source":"Crossref","is-referenced-by-count":24,"special_numbering":"S1","title":["Role of Aldosterone Blockade for Treatment of Heart Failure and Post\u2013Acute Myocardial Infarction"],"prefix":"10.1016","volume":"97","author":[{"given":"Barry","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"Pitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2006.03.009_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1067\/mhj.2003.53","article-title":"Frequency, patient characteristics, and outcomes of mild-to-moderate heart failure complicating ST-segment elevation acute myocardial infarction","volume":"145","author":"Hasdai","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2006.03.009_bib2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.CIR.0000109691.16944.DA","article-title":"Determinants and prognostic impact of heart failure complicating acute coronary syndromes","volume":"109","author":"Steg","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2006.03.009_bib3","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0735-1097(02)02173-3","article-title":"Hospital outcomes in patients presenting with congestive heart failure complicating acute myocardial infarction","volume":"40","author":"Wu","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2006.03.009_bib4","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/S0002-9149(96)90064-8","article-title":"Importance of congestive heart failure and interaction of congestive heart failure and left ventricular systolic function on prognosis in patients with acute myocardial infarction","volume":"78","author":"Kober","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2006.03.009_bib5","series-title":"Heart Disease and Stroke Statistics\u20142005 Update","year":"2005"},{"key":"10.1016\/j.amjcard.2006.03.009_bib6","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"for the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2006.03.009_bib7","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1161\/01.CIR.0000068340.96506.0F","volume":"107","author":"Hayashi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2006.03.009_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10557-005-0444-9","article-title":"Acute administration of angiotensin converting enzyme inhibitors in thrombolyzed myocardial infarction patients is associated with a decreased incidence of heart failure, but an increased re-infarction risk","volume":"19","author":"Voors","year":"2005","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.amjcard.2006.03.009_bib9","first-page":"II-363","article-title":"Early hemodynamic compromise following uncomplicated primary angioplasty for acute myocardial infarction","volume":"106","author":"Yerkey","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2006.03.009_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10557-005-1496-6","article-title":"Angiotensin converting enzyme inhibitors","volume":"19","author":"Pitt","year":"2005","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.amjcard.2006.03.009_bib11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2006.03.009_bib12","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1001\/jama.293.5.572","article-title":"Risk stratification for in-hospital mortality in acutely decompensated heart failure","volume":"293","author":"Fonarow","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2006.03.009_bib13","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.0000138680.89536.A9","article-title":"Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure","volume":"110","author":"Mottram","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2006.03.009_bib14","unstructured":"National Heart, Lung, and Blood Institute. Selected NHLBI clinical trials across the U.S. Last update: January 1, 2004. Available at: http:\/\/apps.nhlbi.nih.gov\/clinicaltrials\/Contacts.ASP?TrialNumber=160. Accessed March 21, 2005."},{"issue":"suppl 1","key":"10.1016\/j.amjcard.2006.03.009_bib15","first-page":"79","article-title":"Eplerenone benefit at 30 days in high-risk subgroups in the EPHESUS trial","volume":"4","author":"van Veldhuisen","year":"2005","journal-title":"Eur J Heart Fail."},{"key":"10.1016\/j.amjcard.2006.03.009_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejheart.2005.11.008","article-title":"Evaluation of eplerenone in the subgroup of EPHESUS patients with baseline left ventricular ejection fraction \u226430%","author":"Pitt","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2006.03.009_bib17","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1056\/NEJMoa043938","article-title":"Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both","volume":"352","author":"Solomon","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2006.03.009_bib18","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1056\/NEJMoa041489","article-title":"Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction","volume":"351","author":"Hohnloser","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2006.03.009_bib19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0223-5234(03)00049-7","article-title":"Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosis","volume":"38","author":"Hartmann","year":"2003","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.amjcard.2006.03.009_bib20","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1021\/jm0492397","article-title":"Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes\/-indanes and structurally modified derivatives","volume":"48","author":"Ulmschneider","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.amjcard.2006.03.009_bib21","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0735-1097(01)01539-X","article-title":"Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction","volume":"38","author":"Hayashi","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2006.03.009_bib22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0735-1097(95)00520-X","article-title":"Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure","volume":"27","author":"Pacher","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2006.03.009_bib23","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1053\/euhj.2001.2969","article-title":"Prognostic value of two-dimensional echocardiography and N-terminal proatrial natriuretic peptide following an acute myocardial infarction","volume":"23","author":"Otterstad","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2006.03.009_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/01.RES.0000117070.86556.9F","article-title":"B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-\u03b2 in primary human cardiac fibroblasts","volume":"94","author":"Kapoun","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.amjcard.2006.03.009_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-8703(02)94708-3","article-title":"Vasopressin","volume":"146","author":"Lee","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2006.03.009_bib26","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/01.HYP.33.2.663","article-title":"Myocardial osteopontin expression coincides with the development of heart failure","volume":"33","author":"Singh","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.amjcard.2006.03.009_bib27","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1253\/circj.67.742","article-title":"Osteopontin is released from the heart into the coronary circulation in patients with a previous anterior wall myocardial infarction","volume":"67","author":"Tamura","year":"2003","journal-title":"Circ J"},{"key":"10.1016\/j.amjcard.2006.03.009_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/clc.4960270712","article-title":"Relation of circulating interleukin-6 to left ventricular remodeling in patients with reperfused anterior myocardial infarction","volume":"27","author":"Ohtsuka","year":"2004","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.amjcard.2006.03.009_bib29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1054\/jcaf.2003.38","article-title":"Interleukin-6 and tumor necrosis factor \u03b1 in relation to myocardial infarct size and collagen formation","volume":"9","author":"Puhakka","year":"2003","journal-title":"J Card Fail"},{"key":"10.1016\/j.amjcard.2006.03.009_bib30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0167-5273(02)00416-3","article-title":"Serum C-reactive protein elevation in left ventricular remodeling after acute myocardial infarction\u2014role of neurohormones and cytokines","volume":"88","author":"Takahashi","year":"2003","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.amjcard.2006.03.009_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10380-003-0692-2","article-title":"High-sensitivity C-reactive protein and left ventricular remodeling in patients with acute myocardial infarction","volume":"18","author":"Uehara","year":"2003","journal-title":"Heart Vessels"},{"key":"10.1016\/j.amjcard.2006.03.009_bib32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1388-9842(02)00092-2","article-title":"Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy","volume":"4","author":"Schwartzkopff","year":"2002","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2006.03.009_bib33","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/384353a0","article-title":"Inhibition of myocardial endothelin pathway improves long-term survival in heart failure","volume":"384","author":"Sakai","year":"1996","journal-title":"Nature"},{"issue":"suppl A","key":"10.1016\/j.amjcard.2006.03.009_bib34","article-title":"The effect of eplerenone on markers of cardiac fibrosis","volume":"43","author":"Zannad","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"suppl","key":"10.1016\/j.amjcard.2006.03.009_bib35","first-page":"P2912","article-title":"The effect of eplerenone on the cytokine osteopontin in post-AMI heart failure","volume":"25","author":"Ketelslegers","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2006.03.009_bib36","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1161\/hh1001.090842","article-title":"Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin","volume":"88","author":"Trueblood","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.amjcard.2006.03.009_bib37","doi-asserted-by":"crossref","first-page":"H1730","DOI":"10.1152\/ajpheart.00098.2004","article-title":"Increased cell death in osteopontin-deficient cardiac fibroblasts occurs by a caspase 3\u2013independent pathway","volume":"287","author":"Zohar","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914906004620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914906004620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T05:54:57Z","timestamp":1547704497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914906004620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0002914906004620"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2006.03.009","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}