{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:34:32Z","timestamp":1762641272726},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.amjcard.2008.09.093","type":"journal-article","created":{"date-parts":[[2008,11,23]],"date-time":"2008-11-23T09:10:53Z","timestamp":1227431453000},"page":"375-380","source":"Crossref","is-referenced-by-count":28,"title":["Usefulness of Genetic Polymorphisms and Conventional Risk Factors to Predict Coronary Heart Disease in Patients With Familial Hypercholesterolemia"],"prefix":"10.1016","volume":"103","author":[{"given":"Jeroen B.","family":"van der Net","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Cecile J.W.","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joep C.","family":"Defesche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.P.","family":"Kastelein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.G.","family":"Sijbrands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewout W.","family":"Steyerberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2008.09.093_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/jmg.40.3.163","article-title":"A common variant in the ABCA1 gene is associated with a lower risk for premature coronary heart disease in familial hypercholesterolaemia","volume":"40","author":"Cenarro","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.amjcard.2008.09.093_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0021-9150(99)00324-X","article-title":"Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia","volume":"149","author":"Leus","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.amjcard.2008.09.093_bib3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0021-9150(00)00440-8","article-title":"PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients","volume":"154","author":"Leus","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.amjcard.2008.09.093_bib4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0002-9149(00)01103-6","article-title":"Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia","volume":"86","author":"Kawashiri","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2008.09.093_bib5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.ATV.0000014424.18209.21","article-title":"Association of estrogen receptor-alpha gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia","volume":"22","author":"Lu","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2008.09.093_bib6","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1161\/01.CIR.97.18.1780","article-title":"Angiotensin-converting enzyme DD genotype and cardiovascular disease in heterozygous familial hypercholesterolemia","volume":"97","author":"O'Malley","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2008.09.093_bib7","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/01.HYP.36.5.808","article-title":"Renin-angiotensin system polymorphisms and coronary events in familial hypercholesterolemia","volume":"36","author":"Wierzbicki","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.amjcard.2008.09.093_bib8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/01.CIR.97.8.729","article-title":"A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia","volume":"97","author":"Wittekoek","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2008.09.093_bib9","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1161\/01.ATV.19.11.2708","article-title":"A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia","volume":"19","author":"Wittekoek","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2008.09.093_bib10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.clinbiochem.2004.10.005","article-title":"Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia","volume":"38","author":"Roest","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1016\/j.amjcard.2008.09.093_bib11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0002-9149(00)01429-6","article-title":"Evaluation of coronary risk factors in patients with heterozygous familial hypercholesterolemia","volume":"87","author":"Hopkins","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2008.09.093_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.atherosclerosis.2004.10.016","article-title":"Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia","volume":"179","author":"Pisciotta","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.amjcard.2008.09.093_bib13","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1161\/01.ATV.0000168909.44877.a7","article-title":"Genetic determinants of cardiovascular disease risk in familial hypercholesterolemia","volume":"25","author":"Jansen","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2008.09.093_bib14","article-title":"Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia","author":"van der Net","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.amjcard.2008.09.093_bib15","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1093\/eurheartj\/ehn303","article-title":"Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia","volume":"29","author":"van der Net","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2008.09.093_bib16","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/eurheartj\/ehn154","article-title":"Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia","volume":"29","author":"van der Net","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2008.09.093_bib17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/01.gim.0000229689.18263.f4","article-title":"Predictive testing for complex diseases using multiple genes: fact or fiction?","volume":"8","author":"Janssens","year":"2006","journal-title":"Genet Med"},{"key":"10.1016\/j.amjcard.2008.09.093_bib18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2796.2004.01405.x","article-title":"The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients","volume":"256","author":"Jansen","year":"2004","journal-title":"J Intern Med"},{"key":"10.1016\/j.amjcard.2008.09.093_bib19","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/ejhg.2008.59","article-title":"Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies","volume":"16","author":"van der Net","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.amjcard.2008.09.093_bib20","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/1471-2458-6-262","article-title":"Relative risk for cardiovascular atherosclerotic events after smoking cessation: 6-9 years excess risk in individuals with familial hypercholesterolemia","volume":"6","author":"Kramer","year":"2006","journal-title":"BMC Public Health"},{"key":"10.1016\/j.amjcard.2008.09.093_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat Med"},{"key":"10.1016\/j.amjcard.2008.09.093_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0895-4356(03)00047-7","article-title":"Internal and external validation of predictive models: a simulation study of bias and precision in small samples","volume":"56","author":"Steyerberg","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.amjcard.2008.09.093_bib23","doi-asserted-by":"crossref","first-page":"R166","DOI":"10.1093\/hmg\/ddn250","article-title":"Genome-based prediction of common diseases: advances and prospects","volume":"17","author":"Janssens","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.amjcard.2008.09.093_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/aje\/kwm060","article-title":"Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study","volume":"166","author":"Morrison","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.amjcard.2008.09.093_bib25","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/hc0302.102575","article-title":"Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the Prospective Cardiovascular Munster (PROCAM) Study","volume":"105","author":"Assmann","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2008.09.093_bib26","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914908017104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914908017104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T05:57:15Z","timestamp":1545631035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914908017104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0002914908017104"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2008.09.093","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}