{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:00:14Z","timestamp":1789952414802,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.amjcard.2010.08.067","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T04:14:22Z","timestamp":1294200862000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Prevalence, Predictors, and Long-Term Prognosis of Premature Discontinuation of Oral Antiplatelet Therapy After Drug Eluting Stent Implantation"],"prefix":"10.1016","volume":"107","author":[{"given":"Roberta","family":"Rossini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Lettieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Nijaradze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoloz","family":"Lortkipanidze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cicorella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Biondi Zoccai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Sirbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Izzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Guagliumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orazio","family":"Valsecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Gavazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2010.08.067_bib1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1161\/01.CIR.0000025585.63486.59","article-title":"Intravascular ultrasound findings in the multicenter, randomized, double-blind RAVEL (RAndomized study with the sirolimus-eluting VElocity balloon-expandable stent in the treatment of patients with de novo native coronary artery lesions) trial","volume":"106","author":"Serruys","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/01.CIR.0000086926.62288.A6","article-title":"Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions","volume":"108","author":"Colombo","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib3","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMoa035071","article-title":"Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery","volume":"349","author":"Moses","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2010.08.067_bib4","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1001\/jama.295.11.1253","article-title":"Paclitaxel-eluting stents vs vascular brachytherapy for in-stent restenosis within bare-metal stents: the TAXUS V ISR randomized trial","volume":"295","author":"Stone","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2010.08.067_bib5","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1161\/01.CIR.0000038984.30279.89","article-title":"Coated stents for the prevention of restenosis","volume":"106","author":"Babapulle","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2006.03.042","article-title":"Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk","volume":"48","author":"Joner","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2010.08.067_bib7","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1161\/CIRCULATIONAHA.107.693739","article-title":"Pathological correlates of late DES thrombosis","volume":"115","author":"Finn","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/01.CIR.0000116202.41966.D4","article-title":"Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious?","volume":"109","author":"Virmani","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.carrad.2004.11.001","article-title":"Late thrombosis in cypher stents after the discontinuation of antiplatelet therapy","volume":"5","author":"Stabile","year":"2004","journal-title":"Cardiovasc Radiat Med"},{"key":"10.1016\/j.amjcard.2010.08.067_bib10","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.jacc.2005.02.086","article-title":"Late angiographic stent thrombosis (LAST) events with drug-eluting stents","volume":"45","author":"Ong","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2010.08.067_bib11","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S0140-6736(04)17275-9","article-title":"Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy","volume":"364","author":"McFadden","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2010.08.067_bib12","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1161\/CIRCULATIONAHA.106.686048","article-title":"Incidence and predictors of drug-eluting stent thrombosis during and after discontinuation of thienopyridine treatment","volume":"116","author":"Airoldi","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib13","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1093\/eurheartj\/ehp275","article-title":"Stent thrombosis after drug-eluting stent implantation: incidence, timing, and relation to discontinuation of clopidogrel therapy over a 4-year period","volume":"30","author":"Schulz","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2010.08.067_bib14","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1001\/jama.293.17.2126","article-title":"Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents","volume":"293","author":"Iakovou","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2010.08.067_bib15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/CIRCULATIONAHA.106.180944","article-title":"A Science Advisory From the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, American Dental Association, American College of Physicians","volume":"115","author":"Grines","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib16","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.jacc.2009.10.015","volume":"54","author":"Kushner","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2010.08.067_bib17","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1161\/CIRCULATIONAHA.106.618066","article-title":"Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry","volume":"113","author":"Spertus","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib18","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.ahj.2009.02.013","article-title":"Aspirin noncompliance is the major cause of \u201caspirin resistance\u201d in patients undergoing coronary stenting","volume":"157","author":"Cuisset","year":"2009","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2010.08.067_bib19","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/CIRCULATIONAHA.108.808311","article-title":"Antiplatelet therapy and stent thrombosis after sirolimus-eluting stent implantation","volume":"119","author":"Kimura","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib20","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/CIRCULATIONAHA.108.813667","article-title":"Safety of short-term discontinuation of antiplatelet therapy in patients with drug-eluting stents","volume":"119","author":"Eisenberg","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib21","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.ehj.2004.03.006","article-title":"Long-term clopidogrel therapy after percutaneous coronary intervention in PCI-CURE and CREDO: the \u201cEmperor's New Clothes\u201d revisited","volume":"25","author":"Eriksson","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2010.08.067_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1001\/jama.297.2.joc60179","article-title":"Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation","volume":"297","author":"Eisenstein","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2010.08.067_bib23","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jacc.2008.12.055","article-title":"Predictors of coronary stent thrombosis: the Dutch Stent Thrombosis Registry","volume":"53","author":"van Werkum","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2010.08.067_bib24","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1056\/NEJMoa067731","article-title":"Stent thrombosis in randomized clinical trials of drug-eluting stents","volume":"356","author":"Mauri","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2010.08.067_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0735-1097(88)90158-1","article-title":"Thrombolysis In Myocardial Infarction (TIMI) Trial\u2014phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase","volume":"11","author":"Rao","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2010.08.067_bib26","doi-asserted-by":"crossref","first-page":"e378","DOI":"10.1161\/CIRCULATIONAHA.107.726992","article-title":"Coronary stents and noncardiac surgery","volume":"116","author":"Riddell","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/01.CIR.0000078636.71728.40","article-title":"Predictors of subacute stent thrombosis: results of a systematic intravascular ultrasound study","volume":"108","author":"Cheneau","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib28","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1161\/01.CIR.103.15.1967","article-title":"Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials","volume":"103","author":"Cutlip","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib29","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1161\/01.CIR.0000127105.99982.21","article-title":"Stent thrombosis after successful sirolimus-eluting stent implantation","volume":"109","author":"Jeremias","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2010.08.067_bib30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1001\/jama.299.5.532","article-title":"Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome","volume":"299","author":"Ho","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2010.08.067_bib31","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.jacc.2008.08.047","article-title":"The ELAPSE","volume":"52","author":"Saw","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2010.08.067_bib32","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1056\/NEJMoa1001266","article-title":"Duration of dual antiplatelet therapy after implantation of drug-eluting stents","volume":"362","author":"Park","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2010.08.067_bib33","first-page":"1279","article-title":"Identifying the \u201coptimal\u201d duration of dual antiplatelet therapy after drug-eluting stent revascularization","volume":"2","author":"Kandzari","year":"2009","journal-title":"J Am Coll Cardiol Cardiovasc Interv"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914910018564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914910018564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:21:08Z","timestamp":1757571668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914910018564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0002914910018564"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2010.08.067","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence, Predictors, and Long-Term Prognosis of Premature Discontinuation of Oral Antiplatelet Therapy After Drug Eluting Stent Implantation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2010.08.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}