{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:37:46Z","timestamp":1791823066025,"version":"4.3.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.amjcard.2012.01.361","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:32:17Z","timestamp":1329870737000},"page":"1459-1465","source":"Crossref","is-referenced-by-count":26,"title":["Congenital Long QT 3 in the Pediatric Population"],"prefix":"10.1016","volume":"109","author":[{"given":"Andrew D.","family":"Blaufox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Tristani-Firouzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Seslar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhayan","family":"Sanatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavya","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fischbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Lon","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svjetlana","family":"Tisma-Dupanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Cuneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harinder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronn E.","family":"Tanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Etheridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2012.01.361_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1161\/01.CIR.103.1.89","article-title":"Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias","volume":"103","author":"Schwartz","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.01.361_bib2","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1001\/jama.292.11.1341","article-title":"Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers","volume":"292","author":"Priori","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2012.01.361_bib3","doi-asserted-by":"crossref","first-page":"e385","DOI":"10.1161\/CIRCULATIONAHA.106.178233","volume":"114","author":"Zipes","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.01.361_bib4","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.jacc.2007.05.042","article-title":"Long QT syndrome in children in the era of implantable defibrillators","volume":"50","author":"Etheridge","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2012.01.361_bib5","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/CIRCULATIONAHA.110.950147","article-title":"Who are the long-QT syndrome patients who receive an implantable cardioverter-defibrillator and what happens to them?","volume":"122","author":"Schwartz","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.01.361_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.hrthm.2008.10.017","article-title":"All LQT3 patients need an ICD: true or false?","volume":"6","author":"Schwartz","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.amjcard.2012.01.361_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.amjcard.2009.08.676","article-title":"Mutation-specific risk in two genetic forms of type 3 long QT syndrome","volume":"105","author":"Liu","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2012.01.361_bib8","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/humu.21106","article-title":"The genetic basis of long QT and short QT syndromes: a mutation update","volume":"30","author":"Hedley","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.amjcard.2012.01.361_bib9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1067\/mhj.2002.125804","article-title":"Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management","volume":"144","author":"Anderson","year":"2002","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2012.01.361_bib10","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1172\/JCI9212","article-title":"A revised view of cardiac sodium channel \u201cblockade\u201d in the long-QT syndrome","volume":"105","author":"Kambouris","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.amjcard.2012.01.361_bib11","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1161\/01.CIR.96.9.2778","article-title":"KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome","volume":"96","author":"Donger","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.01.361_bib12","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1056\/NEJM199810013391404","article-title":"Influence of genotype on the clinical course of the long-QT syndrome","volume":"339","author":"Zareba","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2012.01.361_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0735-1097(03)00554-0","article-title":"International Long QT Registry","volume":"42","author":"Zareba","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2012.01.361_bib14","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1161\/CIRCULATIONAHA.107.701243","article-title":"Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome","volume":"117","author":"Goldenberg","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.01.361_bib15","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1001\/jama.296.10.1249","article-title":"Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome","volume":"296","author":"Hobbs","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2012.01.361_bib16","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.jacc.2008.01.033","article-title":"Results of a multicenter retrospective implantable cardioverter-defibrillator registry of pediatric and congenital heart disease patients","volume":"51","author":"Berul","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2012.01.361_bib17","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.hrthm.2010.08.023","article-title":"Implantable cardioverter defibrillator therapy for congenital long QT syndrome: a single-center experience","volume":"7","author":"Horner","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.amjcard.2012.01.361_bib18","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1161\/CIRCULATIONAHA.107.707877","article-title":"Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients","volume":"116","author":"Ruan","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.01.361_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/heart.90.1.13","article-title":"Long QT syndrome and life threatening arrhythmia in a newborn: molecular diagnosis and treatment response","volume":"90","author":"Schulze-Bahr","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.amjcard.2012.01.361_bib20","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1161\/01.CIR.92.12.3381","article-title":"Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate","volume":"92","author":"Schwartz","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.01.361_bib21","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1161\/01.CIR.101.14.1698","article-title":"Effects of flecainide in patients with new SCN5A mutation: mutation-specific therapy for long-QT syndrome?","volume":"101","author":"Benhorin","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.01.361_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1542-474X.2005.00077.x","article-title":"Safety and efficacy of flecainide in subjects with Long QT-3 syndrome (DeltaKPQ mutation): a randomized, double-blind, placebo-controlled clinical trial","volume":"10","author":"Moss","year":"2005","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1016\/j.amjcard.2012.01.361_bib23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/cvr\/cvq029","article-title":"Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3","volume":"87","author":"Fabritz","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.amjcard.2012.01.361_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.RES.0000052672.97759.36","article-title":"Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system","volume":"92","author":"Bezzina","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.amjcard.2012.01.361_bib25","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.hrthm.2010.04.014","article-title":"Epidemiologic, molecular, and functional evidence suggest A572D-SCN5A should not be considered an independent LQT3-susceptibility mutation","volume":"7","author":"Tester","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.amjcard.2012.01.361_bib26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.hrthm.2005.01.020","article-title":"Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing","volume":"2","author":"Tester","year":"2005","journal-title":"Heart Rhythm"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914912004614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914912004614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T23:57:36Z","timestamp":1543190256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914912004614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0002914912004614"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2012.01.361","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}