{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:19:55Z","timestamp":1782836395328,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 DK 74151"],"award-info":[{"award-number":["R01 DK 74151"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1 RR-024134"],"award-info":[{"award-number":["UL1 RR-024134"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["MO1 RR-16500"],"award-info":[{"award-number":["MO1 RR-16500"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1 RR-024989"],"award-info":[{"award-number":["UL1 RR-024989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["MO1 RR-000042"],"award-info":[{"award-number":["MO1 RR-000042"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1 RR-024986"],"award-info":[{"award-number":["UL1 RR-024986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1 RR-029879"],"award-info":[{"award-number":["UL1 RR-029879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1 RR-024131"],"award-info":[{"award-number":["UL1 RR-024131"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U01-DK060990"],"award-info":[{"award-number":["U01-DK060990"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Vivian S. Lasko Research Fund"},{"name":"Nina C. Mackall Trust"},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.amjcard.2012.03.014","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T08:19:59Z","timestamp":1334737199000},"page":"246-253","source":"Crossref","is-referenced-by-count":46,"title":["Association Between Retinopathy and Cardiovascular Disease in Patients With Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort [CRIC] Study)"],"prefix":"10.1016","volume":"110","author":[{"given":"Juan E.","family":"Grunwald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Shuang","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Pistilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revell","family":"Whittock-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile","family":"Mohler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Chia-Mei","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal Ann","family":"Gadegbeku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Phillip","family":"Lash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey Craig","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboob","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Walter","family":"Kusek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Gerard","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2012.03.014_bib1","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1097\/01.ASN.0000070149.78399.CE","article-title":"The Chronic Renal Insufficiency Cohort (CRIC) study: design and methods","volume":"14","author":"Feldman","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib2","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2215\/CJN.00070109","article-title":"Chronic Renal Insufficiency Cohort (CRIC) study: baseline characteristics and associations with kidney function","volume":"4","author":"Lash","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2215\/CJN.08271109","article-title":"Prevalence of ocular fundus pathology in subjects with chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study","volume":"5","author":"Grunwald","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib4","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/S0161-6420(99)90525-0","article-title":"Methods for evaluation of retinal microvascular abnormalities associated with hypertension\/sclerosis in the Atherosclerosis Risk In Communities Study","volume":"106","author":"Hubbard","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.amjcard.2012.03.014_bib5","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0161-6420(13)38012-9","article-title":"Grading diabetic retinopathy from stereoscopic color fundus photographs\u2014an extension of the Modified Airlie House classification","volume":"98","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.amjcard.2012.03.014_bib6","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ajo.2005.08.063","article-title":"Diabetic retinopathy in a multi-ethnic cohort in the United States","volume":"141","author":"Wong","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjcard.2012.03.014_bib8","series-title":"The Eye in Systemic Disease","first-page":"79","article-title":"Diabetes mellitus","author":"Davis","year":"1990"},{"key":"10.1016\/j.amjcard.2012.03.014_bib9","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1161\/01.ATV.20.6.1644","article-title":"Are retinal arteriolar abnormalities related to atherosclerosis?","volume":"20","author":"Klein","year":"2000","journal-title":"Atheroscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib10","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/archophthalmol.2009.172","article-title":"The relation of markers of inflammation and endothelial dysfunction to the prevalence and progression of diabetic retinopathy","volume":"127","author":"Klein","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib11","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archopht.1986.01050190049038","article-title":"Laser Doppler velocimetry study of the retinal circulation in diabetes mellitus","volume":"104","author":"Grunwald","year":"1986","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib12","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0161-6420(84)34124-0","article-title":"Altered retinal vascular response to 100% O2 breathing in diabetes mellitus","volume":"91","author":"Grunwald","year":"1984","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.amjcard.2012.03.014_bib13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0026-0495(83)90210-X","article-title":"Hemodynamic factors in the genesis of diabetic microangiopathy","volume":"32","author":"Parving","year":"1983","journal-title":"Metabolism"},{"key":"10.1016\/j.amjcard.2012.03.014_bib14","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/S0161-6420(82)34663-1","article-title":"Pathophysiology of hypertensive retinopathy","volume":"89","author":"Tso","year":"1982","journal-title":"Ophthalmology"},{"key":"10.1016\/j.amjcard.2012.03.014_bib15","first-page":"167","article-title":"Experimental hypertensive retinopathy in the monkey","volume":"88","author":"Ashton","year":"1969","journal-title":"Ophthalmol Trans Soc UK"},{"key":"10.1016\/j.amjcard.2012.03.014_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/bjo.59.1.3","article-title":"Pathogenesis of hypertensive retinopathy: an experimental study in the monkey","volume":"59","author":"Garner","year":"1975","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib17","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/01.CIR.75.6.1130","article-title":"Quantitative analysis of narrowings of intramyocardial small arteries in normal hearts, hypertensive hearts, and hearts with hypertrophic cardiomyopathy","volume":"75","author":"Tanaka","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.03.014_bib18","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1161\/01.ATV.17.4.760","article-title":"Cardiovascular risk factors and hyalinization of renal arterioles at autopsy: the Honolulu Heart Program","volume":"17","author":"Burchfiel","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/oxfordjournals.aje.a115184","article-title":"The Atherosclerosis Risk In Communities (ARIC) Study research group: design and objectives","volume":"129","year":"1989","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/oxfordjournals.aje.a009997","article-title":"Retinal arteriolar diameters and elevated blood pressure: the Atherosclerosis Risk In Communities Study","volume":"150","author":"Sharrett","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib21","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1136\/bjo.86.9.1007","article-title":"Retinal microvascular abnormalities and blood pressure in older people: the cardiovascular health study","volume":"86","author":"Wong","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib22","first-page":"29","article-title":"The relation of systemic hypertension to changes in the retinal vasculature: the Beaver Dam Eye Study","volume":"95","author":"Klein","year":"1997","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.amjcard.2012.03.014_bib23","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1167\/iovs.05-1539","article-title":"Retinal vascular caliber, cardiovascular risk factors and inflammation: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"47","author":"Wong","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.amjcard.2012.03.014_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.survophthal.2008.10.003","article-title":"Retinal vascular caliber: systemic, environmental and genetic associations","volume":"54","author":"Sun","year":"2009","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib25","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2337\/diabetes.55.02.06.db05-0546","article-title":"Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the Rotterdam study","volume":"44","author":"Ikram","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.amjcard.2012.03.014_bib26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archophthalmol.2010.340","article-title":"Retinal venular diameter as an early indicator of progression to proliferative diabetic retinopathy with and without high-risk characteristics in African Americans with type 1 diabetes mellitus","volume":"129","author":"Roy","year":"2011","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.amjcard.2012.03.014_bib27","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1167\/iovs.10-5927","article-title":"The relationship between retinal arteriolar and venular calibers is genetically mediated, and each is associated with risk of cardiovascular disease","volume":"52","author":"Fahi","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.amjcard.2012.03.014_bib28","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1001\/archinte.166.21.2388","article-title":"Quantitative retinal venular caliber and risk of cardiovascular disease in older persons: the cardiovascular health study","volume":"166","author":"Wong","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjcard.2012.03.014_bib29","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1212\/01.wnl.0000210533.24338.ea","article-title":"Retinal vessel diameters and risk of stroke: the Rotterdam study","volume":"66","author":"Ikram","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.amjcard.2012.03.014_bib30","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/j.ajkd.2010.11.025","article-title":"Bidirectional association between retinal vessel diameters and estimated GFR decline: the Beaver Dam CKD Study","volume":"57","author":"Sabanayagam","year":"2011","journal-title":"Am J Kidney Dis"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914912009393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914912009393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T18:31:48Z","timestamp":1549650708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914912009393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0002914912009393"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2012.03.014","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}