{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:02:28Z","timestamp":1793383348712,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.amjcard.2012.12.025","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T04:17:31Z","timestamp":1358396251000},"page":"1046-1051","source":"Crossref","is-referenced-by-count":35,"title":["Hospitalizations and Mortality in the United States for Adults With Down Syndrome and Congenital Heart Disease"],"prefix":"10.1016","volume":"111","author":[{"given":"Fernando","family":"Baraona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Gurvitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Landzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Opotowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2012.12.025_bib1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/bdra.20735","article-title":"Updated national birth prevalence estimates for selected birth defects in the United States 2004\u20132006","volume":"88","author":"Parker","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.amjcard.2012.12.025_bib2","doi-asserted-by":"crossref","first-page":"b3794","DOI":"10.1136\/bmj.b3794","article-title":"Trends in Down's syndrome live births and antenatal diagnoses in England and Wales from 1989 to 2008: analysis of data from the National Down Syndrome Cytogenetic Register","volume":"339","author":"Morris","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.amjcard.2012.12.025_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1469-8749.2004.tb00483.x","article-title":"Clinical, social, and ethical implications of changing life expectancy in Down syndrome","volume":"46","author":"Bittles","year":"2004","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.amjcard.2012.12.025_bib4","first-page":"1","article-title":"Delayed childbearing: more women are having their first child later in life","author":"Matthews","year":"2009","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.amjcard.2012.12.025_bib5","first-page":"580","article-title":"Report on the longevity and the causes of death in mongoloidism in the state of Victoria","volume":"100","author":"Brothers","year":"1954","journal-title":"J\u00a0Ment Sci"},{"key":"10.1016\/j.amjcard.2012.12.025_bib6","first-page":"177","article-title":"Longevity and mortality in Down's syndrome","volume":"26","author":"Thase","year":"1982","journal-title":"J\u00a0Ment Defic Res"},{"key":"10.1016\/j.amjcard.2012.12.025_bib7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1046\/j.1365-2788.2002.00392.x","article-title":"Utilization of medical care among children with Down's syndrome","volume":"46","author":"Frid","year":"2002","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.amjcard.2012.12.025_bib8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jpeds.2008.02.046","article-title":"Health care expenditures for infants and young children with Down syndrome in a privately insured population","volume":"153","author":"Boulet","year":"2008","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.amjcard.2012.12.025_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1747-0803.2009.00349.x","article-title":"Adults with Down syndrome: safety and long-term outcome of cardiac operation","volume":"5","author":"Majdalany","year":"2010","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.amjcard.2012.12.025_bib10","first-page":"50","article-title":"Adults with Down's syndrome: the prevalence of complications and health care in the community","volume":"57","author":"Henderson","year":"2007","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.amjcard.2012.12.025_bib11","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1136\/hrt.2010.197509","article-title":"Congenital heart defects are under-recognised in adult patients with Down's syndrome","volume":"96","author":"Vis","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.amjcard.2012.12.025_bib12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8","article-title":"Population-based study of congenital heart defects in Down syndrome","volume":"80","author":"Freeman","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.amjcard.2012.12.025_bib13","unstructured":"Agency for Healthcare Research and Quality. Overview of the Nationwide Inpatient Sample. Available at: http:\/\/www.hcup-us.ahrq.gov\/nisoverview.jsp. Accessed March 20, 2012."},{"key":"10.1016\/j.amjcard.2012.12.025_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00005650-199801000-00004","article-title":"Comorbidity measures for use with administrative data","volume":"36","author":"Elixhauser","year":"1998","journal-title":"Med Care"},{"key":"10.1016\/j.amjcard.2012.12.025_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/GIM.0b013e3181634867","article-title":"Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project","volume":"10","author":"Freeman","year":"2008","journal-title":"Genet Med"},{"key":"10.1016\/j.amjcard.2012.12.025_bib16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/ajmg.10803","article-title":"Correlation between abnormal cardiac physical examination and echocardiographic findings in neonates with Down syndrome","volume":"113","author":"McElhinney","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.amjcard.2012.12.025_bib17","first-page":"44","article-title":"Study of Down syndrome in 238,942 consecutive births","volume":"41","author":"Stoll","year":"1998","journal-title":"Ann Genet"},{"key":"10.1016\/j.amjcard.2012.12.025_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/(SICI)1096-8628(19980605)77:5<431::AID-AJMG15>3.0.CO;2-J","article-title":"Anomalies in Down syndrome individuals in a large population-based registry","volume":"77","author":"Torfs","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.amjcard.2012.12.025_bib19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ridd.2011.09.026","article-title":"Morbidity and hospitalizations of adults with Down syndrome","volume":"33","author":"Tenenbaum","year":"2012","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.amjcard.2012.12.025_bib20","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(02)08092-3","article-title":"Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study","volume":"359","author":"Yang","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2012.12.025_bib21","first-page":"603","article-title":"Life expectancy of persons with Down syndrome","volume":"95","author":"Eyman","year":"1991","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.amjcard.2012.12.025_bib22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3476(87)80395-5","article-title":"Life expectancy in Down syndrome","volume":"110","author":"Baird","year":"1987","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.amjcard.2012.12.025_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0167-5273(90)90156-Y","article-title":"Down's syndrome: different distribution of congenital heart diseases between the sexes","volume":"27","author":"Pinto","year":"1990","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.amjcard.2012.12.025_bib24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.106.627224","article-title":"Congenital heart disease in the general population: changing prevalence and age distribution","volume":"115","author":"Marelli","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2012.12.025_bib25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/ajhb.10132","article-title":"Comparative survival advantage of males with Down syndrome","volume":"15","author":"Glasson","year":"2003","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.amjcard.2012.12.025_bib26","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jacc.2009.04.037","article-title":"Trends in hospitalizations for adults with congenital heart disease in the U.S","volume":"54","author":"Opotowsky","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914912025696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914912025696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T12:57:45Z","timestamp":1539953865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914912025696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0002914912025696"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2012.12.025","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}