{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:36:12Z","timestamp":1774355772134,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.amjcard.2013.02.005","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T13:30:28Z","timestamp":1364218228000},"page":"1557-1562","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Adding Ezetimibe to Statin to Achieve Low-Density Lipoprotein Cholesterol Goal (from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation [COURAGE] Trial)"],"prefix":"10.1016","volume":"111","clinical-trial-number":[{"clinical-trial-number":"nct00007657","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"David J.","family":"Maron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela M.","family":"Hartigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Neff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Boden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2013.02.005_bib1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.amjcard.2006.07.082","article-title":"The evolving pattern of symptomatic coronary artery disease in the United States and Canada: baseline characteristics of the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial","volume":"99","author":"Boden","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2013.02.005_bib2","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.ahj.2005.08.015","article-title":"Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial Veterans Affairs Cooperative Studies Program No. 424","volume":"151","author":"Boden","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2013.02.005_bib3","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.jacc.2009.10.062","article-title":"Intensive multifactorial intervention for stable coronary artery disease: optimal medical therapy in the COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) trial","volume":"55","author":"Maron","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2013.02.005_bib4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines","volume":"110","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2013.02.005_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/pmed.1996.0050","article-title":"A\u00a0controlled trial of physician counseling to promote the adoption of physical activity","volume":"25","author":"Calfas","year":"1996","journal-title":"Prev Med"},{"key":"10.1016\/j.amjcard.2013.02.005_bib6","series-title":"Physcial Activity","first-page":"192","article-title":"Health promotion in practice","author":"Calfas","year":"2006"},{"key":"10.1016\/j.amjcard.2013.02.005_bib7","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2013.02.005_bib8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jada.2008.02.021","article-title":"Validation of the MEDFICTS dietary assessment questionnaire in a diverse population","volume":"108","author":"Mochari","year":"2008","journal-title":"J\u00a0Am Diet Assoc"},{"key":"10.1016\/j.amjcard.2013.02.005_bib9","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1161\/01.CIR.89.3.1333","article-title":"National Cholesterol Education Program. Second report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)","volume":"89","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2013.02.005_bib10","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1161\/CIRCULATIONAHA.106.174516","article-title":"AHA\/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute","volume":"113","author":"Smith","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2013.02.005_bib11","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa070829","article-title":"Optimal medical therapy with or without PCI for stable coronary disease","volume":"356","author":"Boden","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2013.02.005_bib12","series-title":"Nonparametrics: Statistical Methods Based on Ranks","author":"Lehman","year":"1985"},{"key":"10.1016\/j.amjcard.2013.02.005_bib13","series-title":"Analysis of Survival Data","author":"Cox","year":"1984"},{"key":"10.1016\/j.amjcard.2013.02.005_bib14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.amjcard.2005.04.019","article-title":"Results of the National Cholesterol Education (NCEP) Program Evaluation Project Utilizing Novel E-Technology (NEPTUNE) II survey and implications for treatment under the recent NCEP Writing Group recommendations","volume":"96","author":"Davidson","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2013.02.005_bib15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jacl.2010.01.007","article-title":"Loss of early gains in low-density lipoprotein cholesterol goal attainment among high-risk patients","volume":"4","author":"Foody","year":"2010","journal-title":"J\u00a0Clin Lipidol"},{"key":"10.1016\/j.amjcard.2013.02.005_bib16","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1056\/NEJMoa0800742","article-title":"Simvastatin with or without ezetimibe in familial hypercholesterolemia","volume":"358","author":"Kastelein","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2013.02.005_bib17","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1056\/NEJMoa0907569","article-title":"Extended-release niacin or ezetimibe and carotid intima-media thickness","volume":"361","author":"Taylor","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2013.02.005_bib18","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1056\/NEJMe0801842","article-title":"Cholesterol lowering and ezetimibe","volume":"358","author":"Drazen","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2013.02.005_bib19","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJMoa0804602","article-title":"Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis","volume":"359","author":"Rossebo","year":"2008","journal-title":"N\u00a0Engl J Med e"},{"key":"10.1016\/j.amjcard.2013.02.005_bib20","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0140-6736(11)60739-3","article-title":"The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial","volume":"377","author":"Baigent","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2013.02.005_bib21","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.amjcard.2010.01.363","article-title":"Observed and predicted reduction of ischemic cardiovascular events in the Simvastatin and Ezetimibe in Aortic Stenosis trial","volume":"105","author":"Holme","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2013.02.005_bib22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ahj.2010.03.004","article-title":"An update on the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design","volume":"159","author":"Califf","year":"2010","journal-title":"Am Heart\u00a0J"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914913005274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914913005274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T06:02:11Z","timestamp":1562824931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914913005274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0002914913005274"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2013.02.005","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}