{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:44:35Z","timestamp":1791179075810,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007033","name":"Lincy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.amjcard.2013.05.036","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T10:01:03Z","timestamp":1371895263000},"page":"1019-1024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Cardiac Steatosis and Left Ventricular Hypertrophy in Patients With\u00a0Generalized Lipodystrophy as Determined by Magnetic Resonance Spectroscopy and Imaging"],"prefix":"10.1016","volume":"112","author":[{"given":"Michael D.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Victor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Szczepaniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinaya","family":"Simha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhimanyu","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia S.","family":"Szczepaniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2013.05.036_bib1","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/jc.2011-1159","article-title":"Lipodystrophies: genetic and acquired body fat disorders","volume":"96","author":"Garg","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.amjcard.2013.05.036_bib2","doi-asserted-by":"crossref","first-page":"E977","DOI":"10.1152\/ajpendo.1999.276.5.E977","article-title":"Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo","volume":"276","author":"Szczepaniak","year":"1999","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.amjcard.2013.05.036_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2337\/diacare.26.1.30","article-title":"Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy","volume":"26","author":"Simha","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.amjcard.2013.05.036_bib4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ecl.2004.03.003","article-title":"Lipodystrophies: rare disorders causing metabolic syndrome","volume":"33","author":"Garg","year":"2004","journal-title":"Endocrinol Metab Clin of North Am"},{"key":"10.1016\/j.amjcard.2013.05.036_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/MD.0b013e3181e9442f","article-title":"Cardiomyopathy in congenital and acquired generalized lipodystrophy: a clinical assessment","volume":"89","author":"Lupsa","year":"2010","journal-title":"Medicine"},{"key":"10.1016\/j.amjcard.2013.05.036_bib6","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/archinte.1916.00080130010002","article-title":"A\u00a0formula to estimate the approximate surface area if height and weight be known","volume":"17","author":"DuBois","year":"1916","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjcard.2013.05.036_bib7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1530\/EJE-12-0969","article-title":"Cholic acid for hepatic steatosis in patients with lipodystrophy: a randomized, controlled trial","volume":"168","author":"Ahmad","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.amjcard.2013.05.036_bib8","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/CIRCULATIONAHA.106.645614","article-title":"Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study","volume":"116","author":"McGavock","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2013.05.036_bib9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0002-9149(92)90865-V","article-title":"Left ventricular dimensions and mass using magnetic resonance imaging in female endurance athletes","volume":"69","author":"Riley-Hagan","year":"1992","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2013.05.036_bib10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/mrm.10086","article-title":"Bulk magnetic susceptibility effects on the assessment of intra- and extramyocellular lipids in vivo","volume":"47","author":"Szczepaniak","year":"2002","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.amjcard.2013.05.036_bib11","doi-asserted-by":"crossref","first-page":"E462","DOI":"10.1152\/ajpendo.00064.2004","article-title":"Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population","volume":"288","author":"Szczepaniak","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.amjcard.2013.05.036_bib12","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1074\/jbc.M008553200","article-title":"Liporegulation in diet-induced obesity: the antisteatotic role of hyperleptinemia","volume":"276","author":"Lee","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.amjcard.2013.05.036_bib13","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1006\/jmcc.2002.2061","article-title":"Peroxisome proliferator-activated Receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart","volume":"34","author":"Finck","year":"2002","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.amjcard.2013.05.036_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1172\/JCI0214080","article-title":"The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus","volume":"109","author":"Finck","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.amjcard.2013.05.036_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJM197501022920108","article-title":"Case 1\u20131975","volume":"292","author":"Arky","year":"1975","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2013.05.036_bib16","first-page":"3077","article-title":"Postmortem findings in congenital generalized lipodystrophy","volume":"80","author":"Chandalia","year":"1995","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.amjcard.2013.05.036_bib17","first-page":"358","article-title":"Peculiar distribution of adipose tissue in patients with congenital generalized lipodystrophy","volume":"75","author":"Garg","year":"1992","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.amjcard.2013.05.036_bib18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.carpath.2004.08.005","article-title":"The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts","volume":"13","author":"Corradi","year":"2004","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.amjcard.2013.05.036_bib19","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.amjcard.2004.06.075","article-title":"Relation between epicardial adipose tissue and left ventricular mass","volume":"94","author":"Iacobellis","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2013.05.036_bib20","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/oby.2008.251","article-title":"Substantial changes in epicardial fat thickness after weight loss in severely obese subjects","volume":"16","author":"Iacobellis","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.amjcard.2013.05.036_bib21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1172\/JCI10947","article-title":"A\u00a0novel mouse model of lipotoxic cardiomyopathy","volume":"107","author":"Chiu","year":"2001","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.amjcard.2013.05.036_bib22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/HYPERTENSIONAHA.110.160655","article-title":"A\u00a0murine model of isolated cardiac steatosis leads to cardiomyopathy","volume":"57","author":"Glenn","year":"2011","journal-title":"Hypertension"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914913012344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914913012344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:03:09Z","timestamp":1762077789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914913012344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0002914913012344"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2013.05.036","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac Steatosis and Left Ventricular Hypertrophy in Patients With\u00a0Generalized Lipodystrophy as Determined by Magnetic Resonance Spectroscopy and Imaging","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2013.05.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}