{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:16:01Z","timestamp":1762078561623,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Sinai Hospital of Baltimore"},{"name":"Haemonetics\u00ae Corp"},{"name":"Atherotech\u00ae Inc"},{"name":"Corgenix Medical Corp"},{"name":"OmegaQuant Analytics"}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.amjcard.2015.02.002","type":"journal-article","created":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T20:47:25Z","timestamp":1423687645000},"page":"1204-1211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Relation of Fish Oil Supplementation to Markers of Atherothrombotic Risk in Patients With Cardiovascular Disease Not Receiving Lipid-Lowering Therapy"],"prefix":"10.1016","volume":"115","clinical-trial-number":[{"clinical-trial-number":"nct01276678","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Christopher J.","family":"Franzese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin P.","family":"Bliden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G.","family":"Gesheff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shachi","family":"Pandya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk E.","family":"Guyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Singla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udaya S.","family":"Tantry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"Toth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gurbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2015.02.002_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0925-4439(92)90063-S","article-title":"Maintenance of lower proportions of (n - 6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n - 3) fatty acids","volume":"1180","author":"Lands","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.amjcard.2015.02.002_bib2","doi-asserted-by":"crossref","first-page":"343S","DOI":"10.1093\/ajcn\/71.1.343S","article-title":"Dietary polyunsaturated fatty acids and inflammatory mediator production","volume":"71","author":"James","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.amjcard.2015.02.002_bib3","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1073\/pnas.0334211100","article-title":"Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion","volume":"100","author":"Bagga","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.amjcard.2015.02.002_bib4","first-page":"657","article-title":"Fish oil consumption and reduction of arterial disease","volume":"133","author":"Vanschoonbeek","year":"2003","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.amjcard.2015.02.002_bib5","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1007\/s11745-001-0686-8","article-title":"n-3 polyunsaturated fatty acids and coronary thrombosis","volume":"36","author":"Kristensen","year":"2001","journal-title":"Lipids"},{"key":"10.1016\/j.amjcard.2015.02.002_bib6","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.jacc.2005.07.041","article-title":"Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING Study","volume":"46","author":"Gurbel","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2015.02.002_bib7","first-page":"1297","article-title":"Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans","volume":"142","author":"Harris","year":"2012","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.amjcard.2015.02.002_bib8","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1161\/CIRCULATIONAHA.106.675587","article-title":"Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study","volume":"115","author":"Gurbel","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2015.02.002_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0022-2275(20)40123-3","article-title":"Quantification of cholesterol in all lipoprotein classes by the VAP-II method","volume":"35","author":"Kulkarni","year":"1994","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.amjcard.2015.02.002_bib10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cll.2006.07.004","article-title":"Cholesterol profile measurement by vertical auto profile method","volume":"26","author":"Kulkarni","year":"2006","journal-title":"Clin Lab Med"},{"key":"10.1016\/j.amjcard.2015.02.002_bib11","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.amjcard.2007.09.095","article-title":"Comparison of effects of simvastatin alone versus fenofibrate alone versus simvastatin plus fenofibrate on lipoprotein subparticle profiles in diabetic patients with mixed dyslipidemia (from the Diabetes and Combined Lipid Therapy Regimen study)","volume":"101","author":"May","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2015.02.002_bib12","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1309\/AJCP88WVRDRDFBAS","article-title":"Oxidized-LDL\/beta(2)-glycoprotein I complexes are associated with disease severity and increased risk for adverse outcomes in patients with acute coronary syndromes","volume":"133","author":"Greco","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.amjcard.2015.02.002_bib13","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1161\/01.CIR.0000157138.02645.11","article-title":"Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study","volume":"111","author":"Gurbel","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2015.02.002_bib14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/01.mol.0000236363.63840.16","article-title":"Why do omega-3 fatty acids lower serum triglycerides?","volume":"17","author":"Harris","year":"2006","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.amjcard.2015.02.002_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0021-9150(94)90129-5","article-title":"Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk","volume":"106","author":"Griffin","year":"1994","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.amjcard.2015.02.002_bib16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/01.ATV.0000053385.64132.2D","article-title":"Smallest LDL particles are most strongly related to coronary disease progression in men","volume":"23","author":"Williams","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2015.02.002_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jacc.2012.08.1026","article-title":"Remnant cholesterol as a causal risk factor for ischemic heart disease","volume":"61","author":"Varbo","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2015.02.002_bib18","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/ATVBAHA.111.228593","article-title":"Reduced thrombin formation and altered fibrin clot properties induced by polyunsaturated omega-3 fatty acids on top of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention (OMEGA-PCI clot)","volume":"31","author":"Gajos","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2015.02.002_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.plefa.2010.11.004","article-title":"Omega-3 fatty acids modulate collagen signaling in human platelets","volume":"84","author":"Larson","year":"2011","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.amjcard.2015.02.002_bib20","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0026-0495(92)90286-J","article-title":"Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation","volume":"41","author":"Mori","year":"1992","journal-title":"Metabolism"},{"key":"10.1016\/j.amjcard.2015.02.002_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pcad.2009.05.001","article-title":"Aspirin resistance","volume":"52","author":"Tantry","year":"2009","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.amjcard.2015.02.002_bib22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/jamainternmed.2014.328","article-title":"Effect of long-chain \u03c9-3 fatty acids and lutein\u00a0+ zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial","volume":"174","author":"Bonds","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.amjcard.2015.02.002_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.numecd.2013.12.004","article-title":"Effects of omega-3 fatty acid on major cardiovascular events and mortality in patients with coronary heart disease: a meta-analysis of randomized controlled trials","volume":"24","author":"Wen","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.amjcard.2015.02.002_bib24","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1001\/2012.jama.11374","article-title":"Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis","volume":"308","author":"Rizos","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2015.02.002_bib25","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4065\/83.3.324","article-title":"Omega-3 fatty acids for cardioprotection","volume":"83","author":"Lee","year":"2008","journal-title":"Mayo Clin Proc"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914915006888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914915006888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:04:12Z","timestamp":1762077852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914915006888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0002914915006888"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2015.02.002","relation":{},"ISSN":["0002-9149"],"issn-type":[{"type":"print","value":"0002-9149"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relation of Fish Oil Supplementation to Markers of Atherothrombotic Risk in Patients With Cardiovascular Disease Not Receiving Lipid-Lowering Therapy","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2015.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}