{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:50:57Z","timestamp":1788565857722,"version":"build-2803163510"},"reference-count":9,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajconline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.amjcard.2015.05.039","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T06:10:08Z","timestamp":1433571008000},"page":"730-732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Utility of Routine Exercise Testing to Detect Rate-Related QRS Widening in Patients Without Structural Heart Disease on Class Ic Antiarrhythmic Agents (Flecainide and\u00a0Propafenone)"],"prefix":"10.1016","volume":"116","author":[{"given":"Srikanth","family":"Vallurupalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga Venkata K.","family":"Pothineni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Paydak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2015.05.039_bib1","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1161\/01.CIR.83.6.1987","article-title":"Kinetics of use-dependent ventricular conduction slowing by antiarrhythmic drugs in humans","volume":"83","author":"Ranger","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2015.05.039_bib2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJM199103213241201","article-title":"Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial","volume":"324","author":"Echt","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2015.05.039_bib3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/CIRCULATIONAHA.111.019927","article-title":"Antiarrhythmic drug therapy for atrial fibrillation","volume":"125","author":"Zimetbaum","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2015.05.039_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2796.2011.02395.x","article-title":"The safety of flecainide treatment of atrial fibrillation: long-term incidence of sudden cardiac death and proarrhythmic events","volume":"270","author":"Almroth","year":"2011","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.amjcard.2015.05.039_bib5","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/0735-1097(94)90380-8","article-title":"Ischemia enhances use-dependent sodium channel blockade by pilsicainide, a class IC antiarrhythmic agent","volume":"23","author":"Sadanaga","year":"1994","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2015.05.039_bib6","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS Guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society","volume":"64","author":"January","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2015.05.039_bib7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2165\/00044011-199713060-00005","article-title":"Flecainide-induced increase in QRS duration and proarrhythmia during exercise","volume":"13","author":"Bordier","year":"1997","journal-title":"Clin Drug Invest"},{"key":"10.1016\/j.amjcard.2015.05.039_bib8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0140-6736(12)60570-4","article-title":"Short-term versus long-term antiarrhythmic drug treatment after cardioversion of atrial fibrillation (FLEC-SL): a prospective, randomised, open-label, blinded endpoint assessment trial","volume":"380","author":"Kirchhof","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2015.05.039_bib9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/CIRCEP.113.000681","article-title":"Diffuse ventricular fibrosis is a late outcome of tachycardia-mediated cardiomyopathy after successful ablation","volume":"6","author":"Ling","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291491501423X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291491501423X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T02:55:47Z","timestamp":1537584947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291491501423X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S000291491501423X"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2015.05.039","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Utility of Routine Exercise Testing to Detect Rate-Related QRS Widening in Patients Without Structural Heart Disease on Class Ic Antiarrhythmic Agents (Flecainide and\u00a0Propafenone)","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2015.05.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}