{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T10:11:52Z","timestamp":1777198312397,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajconline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.amjcard.2016.01.013","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T03:50:41Z","timestamp":1453953041000},"page":"1206-1212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of the Effect of Rosuvastatin 2.5\u00a0mg vs 20\u00a0mg on Coronary Plaque Determined by Angioscopy and Intravascular Ultrasound in Japanese With Stable Angina Pectoris (from the Aggressive Lipid-Lowering Treatment Approach Using Intensive Rosuvastatin for Vulnerable Coronary Artery Plaque [ALTAIR] Randomized Trial)"],"prefix":"10.1016","volume":"117","clinical-trial-number":[{"clinical-trial-number":"umin000003276","registry":"10.18810\/umin-japan"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-5854","authenticated-orcid":false,"given":"Tadateru","family":"Takayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Hiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2016.01.013_bib1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1056\/NEJMoa040583","article-title":"Intensive versus moderate lipid lowering with statins after acute coronary syndromes","volume":"350","author":"Cannon","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2016.01.013_bib2","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa050461","article-title":"Intensive lipid lowering with atorvastatin in patients with stable coronary disease","volume":"352","author":"LaRosa","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2016.01.013_bib3","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa064278","article-title":"HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events","volume":"357","author":"Barter","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2016.01.013_bib4","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/jama.291.9.1071","article-title":"Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial","volume":"291","author":"Nissen","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2016.01.013_bib5","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/jama.295.13.jpc60002","article-title":"Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial","volume":"295","author":"Nissen","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2016.01.013_bib6","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1056\/NEJMoa1110874","article-title":"Effect of two intensive statin regimens on progression of coronary disease","volume":"365","author":"Nicholls","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2016.01.013_bib7","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1253\/circj.CJ-08-0755","article-title":"Qualitative and quantitative changes in coronary plaque associated with atorvastatin therapy","volume":"73","author":"Hirayama","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.amjcard.2016.01.013_bib8","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1253\/circj.CJ-10-0038","article-title":"Stabilization and regression of coronary plaques treated with pitavastatin proven by angioscopy and intravascular ultrasound \u2013 the TOGETHAR trial","volume":"74","author":"Kodama","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.amjcard.2016.01.013_bib9","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1253\/circj.CJ-09-0358","article-title":"Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)","volume":"73","author":"Takayama","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.amjcard.2016.01.013_bib10","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.jacc.2010.02.026","article-title":"Intravascular ultrasound-derived measures of coronary atherosclerotic plaque burden and clinical outcome","volume":"55","author":"Nicholls","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.013_bib11","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/j.jacc.2004.09.081","article-title":"Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three-dimensional integrated backscatter intravascular ultrasound","volume":"45","author":"Kawasaki","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.013_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jcmg.2011.11.012","article-title":"Impact of statin therapy on plaque\u00a0characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS","volume":"5","author":"Hattori","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"issue":"25 Suppl. 2","key":"10.1016\/j.amjcard.2016.01.013_bib13","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1161\/01.cir.0000437738.63853.7a","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on practice guidelines","volume":"129","author":"Stone","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2016.01.013_bib14","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1185\/03007995.2011.570746","article-title":"Impact of statins on progression of atherosclerosis: rationale and design of SATURN (Study of Coronary Atheroma by InTravascular Ultrasound: effect of Rosuvastatin versus AtorvastatiN)","volume":"27","author":"Nicholls","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.amjcard.2016.01.013_bib15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jacc.2015.05.065","article-title":"Impact of dual lipid-lowering strategy with ezetimibe and atorvastatin on coronary plaque regression in patients with percutaneous coronary intervention: the multicenter randomized controlled PRECISE-IVUS trial","volume":"66","author":"Tsujita","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.013_bib16","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0735-1097(01)01673-4","article-title":"The healing process of infarct-related plaques: Insights from 18 months of serial angioscopic follow-up","volume":"38","author":"Ueda","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.013_bib17","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.jacc.2006.01.064","article-title":"Number of yellow plaques detected in a coronary artery is associated with future risk of acute coronary syndrome: detection of vulnerable patients by angioscopy","volume":"47","author":"Ohtani","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.013_bib18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ahj.2004.03.047","article-title":"Assessment of plaque vulnerability by angioscopic classification of plaque color","volume":"148","author":"Ueda","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2016.01.013_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ncpcardio1086","article-title":"Rapid regression of atherosclerosis: insights from the clinical and experimental literature","volume":"5","author":"Williams","year":"2008","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"10.1016\/j.amjcard.2016.01.013_bib20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jcin.2009.04.016","article-title":"Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound","volume":"2","author":"Nasu","year":"2009","journal-title":"JACC Cardiovasc Interv"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914916301084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914916301084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T19:20:35Z","timestamp":1537039235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914916301084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0002914916301084"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2016.01.013","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the Effect of Rosuvastatin 2.5\u00a0mg vs 20\u00a0mg on Coronary Plaque Determined by Angioscopy and Intravascular Ultrasound in Japanese With Stable Angina Pectoris (from the Aggressive Lipid-Lowering Treatment Approach Using Intensive Rosuvastatin for Vulnerable Coronary Artery Plaque [ALTAIR] Randomized Trial)","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2016.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}