{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:17:42Z","timestamp":1790194662729,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajconline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.amjcard.2016.01.039","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T13:05:32Z","timestamp":1454331932000},"page":"1127-1134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"title":["Assessment of Device-Related Thrombus and Associated Clinical Outcomes With the WATCHMAN Left Atrial Appendage Closure Device for Embolic Protection in Patients With Atrial Fibrillation (from the PROTECT-AF Trial)"],"prefix":"10.1016","volume":"117","author":[{"given":"Michael L.","family":"Main","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Y.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole T.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina R.","family":"Coggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Rabineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George G.","family":"Latus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shephal K.","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela S.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2016.01.039_bib1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.ahj.2006.02.005","article-title":"The PROTECT AF (WATCMAN left atrial appendage system for embolic protection in patients with atrial fibrillation) trial","volume":"151","author":"Fountain","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2016.01.039_bib2","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","article-title":"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomized non-inferiority trial","volume":"374","author":"Holmes","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2016.01.039_bib3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCULATIONAHA.112.114389","article-title":"Percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation: 2.3 year follow-up of the PROTECT AF (Watchman Left Atrial Appendage System for Embolic Protection in Patient with Atrial Fibrillation) trial","volume":"127","author":"Reddy","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2016.01.039_bib4","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1001\/jama.2014.15192","article-title":"Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial","volume":"312","author":"Reddy","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2016.01.039_bib5","unstructured":"U.S. Food and Drug Administration Recently Approved Devices: WATCHMAN LAA Closure Technology. Available at: http:\/\/www.fda.gov\/MedicalDevices\/ProductsandMedicalProcedures\/DeviceApprovalsandClearances\/Recently-ApprovedDevices\/ucm440621.htm. Accessed on April 8,\u00a02015."},{"key":"10.1016\/j.amjcard.2016.01.039_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/CIRCULATIONAHA.110.976449","article-title":"Safety of percutaneous left atrial appendage closure: results from the watchman left atrial appendage system for embolic protection in patients with AF (PROTECT AF) clinical trial and the continued access registry","volume":"123","author":"Reddy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2016.01.039_bib7","first-page":"565","article-title":"Transesophageal echocardiographic diagnosis of left atrial appendage occluder device infection","volume":"9","author":"Khumri","year":"2008","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.amjcard.2016.01.039_bib8","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/CIRCULATIONAHA.110.004135","article-title":"Thrombus formation on a left atrial appendage closure device","volume":"124","author":"Cardona","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2016.01.039_bib9","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/ccd.23126","article-title":"Thrombus formation after left atrial appendage exclusion using an Amplatzer cardiac plug device","volume":"78","author":"Cruz-Gonzalez","year":"2011","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2016.01.039_bib10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/eurheartj\/ehs437","article-title":"Thrombus formation on an Amplatzer closure device after left atrial appendage closure","volume":"34","author":"Lammers","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2016.01.039_bib11","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1093\/eurheartj\/ehs025","article-title":"Huge left atrial thrombus after left atrial appendage occlusion with a Watchman device","volume":"33","author":"Gasparini","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2016.01.039_bib12","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jcin.2013.02.014","article-title":"Risk factors for thrombus formation on the Amplatzer cardiac plug after left atrial appendage occlusion","volume":"6","author":"Plicht","year":"2013","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2016.01.039_bib13","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/j.1540-8167.2012.02360.x","article-title":"Incomplete endothelialization of left atrial appendage occlusion device 10 months after implantation","volume":"23","author":"Massarenti","year":"2012","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.amjcard.2016.01.039_bib14","first-page":"1086","article-title":"American Society of Echocardiography recommendations for use of echocardiography in clinical trials. A report from the American Society of Echocardiography's guidelines and standards committee and the task force on echocardiography in clinical trials","volume":"17","author":"Gottdiener","year":"2004","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.amjcard.2016.01.039_bib15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.echo.2009.05.020","article-title":"Echocardiographic imaging in clinical trials: an American Society of Echocardiography Standards for echocardiography core laboratories","volume":"22","author":"Douglas","year":"2009","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.amjcard.2016.01.039_bib16","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jcin.2010.04.017","article-title":"Left atrial appendage obliteration: mechanisms of healing and intracardiac integration","volume":"3","author":"Schwartz","year":"2010","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2016.01.039_bib17","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0735-1097(85)80476-9","article-title":"Smoke-like echo in the left atrial cavity in mitral valve disease: its features and significance","volume":"6","author":"Beppu","year":"1985","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.039_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0002-9149(92)90613-4","article-title":"Clinical implications of left atrial spontaneous echo contrast in nonrheumatic atrial fibrillation","volume":"70","author":"Tsai","year":"1992","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.039_bib19","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1161\/01.STR.24.7.1015","article-title":"Left atrial spontaneous echo contrast is highly associated with previous stroke in patients with atrial fibrillation or mitral stenosis","volume":"24","author":"Chimowitz","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.amjcard.2016.01.039_bib20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0735-1097(94)90025-6","article-title":"Prognostic implications of left atrial spontaneous echo contrast in nonvalvular atrial fibrillation","volume":"24","author":"Leung","year":"1994","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.039_bib21","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/0735-1097(94)90133-3","article-title":"Left atrial appendage blood velocity and thromboembolic risk in patients with atrial fibrillation","volume":"24","author":"Fatkin","year":"1994","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.039_bib22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0735-1097(94)90644-0","article-title":"Relations between left atrial appendage blood flow velocity, spontaneous echocardiographic contrast and thromboembolic risk in\u00a0vivo","volume":"23","author":"Fatkin","year":"1994","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.01.039_bib23","doi-asserted-by":"crossref","first-page":"817","DOI":"10.7326\/0003-4819-123-11-199512010-00001","article-title":"Accuracy of transesophageal echocardiography for identifying left atrial thrombi: a\u00a0prospective, intraoperative study","volume":"123","author":"Manning","year":"1995","journal-title":"Ann Intern Med"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914916301618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914916301618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T16:55:27Z","timestamp":1537030527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914916301618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0002914916301618"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2016.01.039","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of Device-Related Thrombus and Associated Clinical Outcomes With the WATCHMAN Left Atrial Appendage Closure Device for Embolic Protection in Patients With Atrial Fibrillation (from the PROTECT-AF Trial)","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2016.01.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}