{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:46:02Z","timestamp":1790516762612,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajconline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.amjcard.2016.04.024","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T05:53:40Z","timestamp":1462082020000},"page":"127-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Abundance and Significance of Iron, Zinc, Copper, and Calcium in the Hearts of Patients With Friedreich Ataxia"],"prefix":"10.1016","volume":"118","author":[{"given":"Pamela C.","family":"Kruger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl X.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa B.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Feustel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulf H.","family":"Koeppen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2016.04.024_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/14734220600913246","article-title":"Iron and iron-responsive proteins in the cardiomyopathy of Friedreich's ataxia","volume":"5","author":"Michael","year":"2006","journal-title":"Cerebellum"},{"key":"10.1016\/j.amjcard.2016.04.024_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2011.01.010","article-title":"Friedreich's ataxia: pathology, pathogenesis, and molecular genetics","volume":"303","author":"Koeppen","year":"2011","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.amjcard.2016.04.024_bib3","doi-asserted-by":"crossref","first-page":"e0116396","DOI":"10.1371\/journal.pone.0116396","article-title":"The pathogenesis of cardiomyopathy in Friedreich ataxia","volume":"10","author":"Koeppen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.amjcard.2016.04.024_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1017\/S0317167100022927","article-title":"The cardiomyopathy of Friedreich's ataxia morphological observations in 3 cases","volume":"7","author":"Lamarche","year":"1980","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.amjcard.2016.04.024_bib5","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1126\/science.271.5254.1423","article-title":"Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion","volume":"271","author":"Campuzano","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.amjcard.2016.04.024_bib6","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.amjcard.2012.08.018","article-title":"Relation of cytosolic iron excess to cardiomyopathy of Friedreich's ataxia","volume":"110","author":"Ramirez","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2016.04.024_bib7","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/00007611-195110000-00011","article-title":"The heart in hemochromatosis","volume":"44","author":"Keschner","year":"1951","journal-title":"South Med J"},{"key":"10.1016\/j.amjcard.2016.04.024_bib8","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0735-1097(87)80124-9","article-title":"Cardiac iron deposition in idiopathic hemochromatosis: histologic and analytic assessment of 14 hearts from autopsy","volume":"10","author":"Olson","year":"1987","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.04.024_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0002-9343(71)90240-3","article-title":"Iron in the heart: etiology and clinical significance","volume":"51","author":"Buja","year":"1971","journal-title":"Am J Med"},{"key":"10.1016\/j.amjcard.2016.04.024_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00365516509077063","article-title":"Concentration of 24 trace elements in human heart tissue determined by neutron activation analysis","volume":"17","author":"Wester","year":"1965","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.amjcard.2016.04.024_bib11","series-title":"The Elemental Composition of Human Tissues and Body Fluids: A Compilation of Values for Adults","first-page":"55","author":"Iyengar","year":"1978"},{"key":"10.1016\/j.amjcard.2016.04.024_bib12","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/0002-8703(78)90503-3","article-title":"Differences in metal content of the heart muscle in death from ischemic heart disease","volume":"95","author":"Chipperfield","year":"1978","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2016.04.024_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0048-9697(89)90367-7","article-title":"Trace elements intake in the Faroe Islands III. Element concentrations in human organs in populations from Bergen (Norway) and the Faroe Islands","volume":"84","author":"Julshamn","year":"1989","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.amjcard.2016.04.024_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0013-9351(05)80248-8","article-title":"Total body burdens and tissue concentrations of lead, cadmium, copper, zinc, and ash in 55 human cadavers","volume":"52","author":"Saltzman","year":"1990","journal-title":"Environ Res"},{"key":"10.1016\/j.amjcard.2016.04.024_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0167-5273(97)00254-4","article-title":"Decreased nuclear encoded subunits of cytochrome c oxidase and increased copper, zinc-superoxide dismutase activity are found in cardiomyopathic human hearts","volume":"62","author":"Liebes","year":"1997","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.amjcard.2016.04.024_bib16","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/S0735-1097(99)00062-5","article-title":"Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction","volume":"33","author":"Frustaci","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.04.024_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0946-672X(02)80004-9","article-title":"Multi-element analysis of trace element levels in human autopsy tissues by using inductively coupled atomic emission spectrometry technique (ICP-AES)","volume":"16","author":"Rahil-Khazen","year":"2002","journal-title":"J\u00a0Trace Elem Med Biol"},{"key":"10.1016\/j.amjcard.2016.04.024_bib18","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.jacc.2015.06.1355","article-title":"Pathology of intercalated discs in Friedreich cardiomyopathy","volume":"66","author":"Ramirez","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.04.024_bib19","first-page":"489S","article-title":"Cardiovascular disease from copper deficiency-a history","volume":"130","author":"Klevay","year":"2000","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.amjcard.2016.04.024_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pharmthera.2014.11.014","article-title":"Role of copper in regression of cardiac hypertrophy","volume":"148","author":"Zheng","year":"2015","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.amjcard.2016.04.024_bib21","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/hmg\/9.5.795","article-title":"Mutations in SCO2 are associated with a distinct form of hypertrophic cardiomyopathy and cytochrome c oxidase deficiency","volume":"9","author":"Jaksch","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.amjcard.2016.04.024_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cmet.2010.04.003","article-title":"Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs","volume":"11","author":"Kim","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/j.amjcard.2016.04.024_bib23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/15513","article-title":"Fatal infantile cardioencephalopathy with COX deficiency and mutations in SCO2, a COX assembly gene","volume":"23","author":"Papadopoulou","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.amjcard.2016.04.024_bib24","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbamcr.2008.05.002","article-title":"\u201cPulling the plug\u201d on cellular copper: the role of mitochondria in copper export","volume":"1793","author":"Leary","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.amjcard.2016.04.024_bib25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ng1097-215","article-title":"Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia","volume":"17","author":"R\u00f6tig","year":"1997","journal-title":"Nat Gen"},{"key":"10.1016\/j.amjcard.2016.04.024_bib26","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nm.3510","article-title":"Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia","volume":"20","author":"Perdomini","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.amjcard.2016.04.024_bib27","doi-asserted-by":"crossref","first-page":"14044","DOI":"10.1038\/mtm.2014.44","article-title":"An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models","volume":"1","author":"G\u00e9rard","year":"2014","journal-title":"Mol Ther Meth Clin Dev"},{"key":"10.1016\/j.amjcard.2016.04.024_bib28","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/ana.24248","article-title":"Deferiprone in Friedreich ataxia: a 6-month randomized controlled trial","volume":"76","author":"Pandolfo","year":"2014","journal-title":"Ann Neurol"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914916305057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914916305057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T15:28:19Z","timestamp":1536766099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914916305057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0002914916305057"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2016.04.024","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abundance and Significance of Iron, Zinc, Copper, and Calcium in the Hearts of Patients With Friedreich Ataxia","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2016.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}