{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:59:05Z","timestamp":1778162345280,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajconline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.amjcard.2016.12.034","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T10:46:22Z","timestamp":1485341182000},"page":"1205-1210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Pioglitazone on Cardiometabolic Risk in Patients With Obstructive Sleep Apnea"],"prefix":"10.1016","volume":"119","author":[{"given":"Alice","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahim","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danit","family":"Ariel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Lamendola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Cardell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailja","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Tomasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafasa","family":"Mojaddidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaylene","family":"Grove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clete A.","family":"Kushida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald M.","family":"Reaven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2016.12.034_bib1","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1152\/japplphysiol.00695.2005","article-title":"Disorders of glucose metabolism in sleep apnea","volume":"99","author":"Punjabi","year":"2005","journal-title":"J\u00a0Appl Physiol (1985)"},{"key":"10.1016\/j.amjcard.2016.12.034_bib2","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1111\/j.1464-5491.2011.03459.x","article-title":"Sleep disturbances and insulin resistance","volume":"28","author":"Van Cauter","year":"2011","journal-title":"Diabet Med"},{"key":"10.1016\/j.amjcard.2016.12.034_bib3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2337\/diabetes.41.3.368","article-title":"Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance","volume":"41","author":"Van Cauter","year":"1992","journal-title":"Diabetes"},{"key":"10.1016\/j.amjcard.2016.12.034_bib4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jacc.2013.05.045","article-title":"Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome","volume":"62","author":"Drager","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2016.12.034_bib5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/01.CIR.0000118216.84358.22","article-title":"Cardiovascular consequences of sleep-disordered breathing: past, present and future: report of a workshop from the National Center on sleep Disorders Research and the National Heart, Lung, and Blood Institute","volume":"109","author":"Quan","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2016.12.034_bib6","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1210\/jcem.86.8.7763","article-title":"Insulin resistance as a predictor of age-related diseases","volume":"86","author":"Facchini","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.amjcard.2016.12.034_bib7","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1210\/jcem.83.8.5005","article-title":"Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease","volume":"83","author":"Yip","year":"1998","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.amjcard.2016.12.034_bib8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.amjcard.2008.02.097","article-title":"Comparison of three treatment approaches to decreasing cardiovascular disease risk in nondiabetic insulin-resistant dyslipidemic subjects","volume":"102","author":"Abbasi","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2016.12.034_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.sleep.2016.06.005","article-title":"Does enhanced insulin sensitivity improve sleep measures in patients with obstructive sleep apnea: a randomized, placebo-controlled pilot study","volume":"22","author":"Liu","year":"2016","journal-title":"Sleep Med"},{"key":"10.1016\/j.amjcard.2016.12.034_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. Deliberations of the sleep apnea Definitions Task Force of the American Academy of Sleep Medicine","volume":"8","author":"Berry","year":"2012","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.amjcard.2016.12.034_bib11","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/BF00404344","article-title":"Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test","volume":"37","author":"Pei","year":"1994","journal-title":"Diabetologia"},{"key":"10.1016\/j.amjcard.2016.12.034_bib12","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1172\/JCI106433","article-title":"Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes","volume":"49","author":"Shen","year":"1970","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.amjcard.2016.12.034_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2337\/diab.30.5.387","article-title":"Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp","volume":"30","author":"Greenfield","year":"1981","journal-title":"Diabetes"},{"key":"10.1016\/j.amjcard.2016.12.034_bib14","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.metabol.2012.10.002","article-title":"Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp","volume":"62","author":"Knowles","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/j.amjcard.2016.12.034_bib15","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1373\/49.6.1014","article-title":"Multiple lipoprotein abnormalities associated with insulin resistance in healthy volunteers are identified by the vertical auto profile-II methodology","volume":"49","author":"Chu","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjcard.2016.12.034_bib16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cll.2006.07.004","article-title":"Cholesterol profile measurement by vertical auto profile method","volume":"26","author":"Kulkarni","year":"2006","journal-title":"Clin Lab Med"},{"key":"10.1016\/j.amjcard.2016.12.034_bib17","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1161\/01.CIR.0000041046.32962.86","article-title":"Differentiation between obesity and insulin resistance in the association with C-reactive protein","volume":"106","author":"McLaughlin","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2016.12.034_bib18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/ajcn\/84.4.813","article-title":"Effects of moderate variations in macronutrient composition on weight loss and reduction in cardiovascular disease risk in obese, insulin-resistant adults","volume":"84","author":"McLaughlin","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.amjcard.2016.12.034_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ecl.2004.12.001","article-title":"Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profile: the price paid to maintain glucose homeostasis in insulin-resistant individuals","volume":"34","author":"Reaven","year":"2005","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.amjcard.2016.12.034_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.smrv.2014.07.004","article-title":"Impact of obstructive sleep apnea treatment by continuous positive airway pressure on cardiometabolic biomarkers: a systematic review from sham CPAP randomized controlled trials","volume":"21","author":"Jullian-Desayes","year":"2015","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.amjcard.2016.12.034_bib21","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1056\/NEJMoa1306187","article-title":"CPAP, weight loss, or both for obstructive sleep apnea","volume":"370","author":"Chirinos","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2016.12.034_bib22","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1001\/jama.2013.281250","article-title":"Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial","volume":"310","author":"Martinez-Garcia","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2016.12.034_bib23","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/jama.2012.4366","article-title":"Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial","volume":"307","author":"Barbe","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2016.12.034_bib24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMoa1606599","article-title":"CPAP for prevention of cardiovascular events in obstructive sleep apnea","volume":"375","author":"McEvoy","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjcard.2016.12.034_bib25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1513\/pats.200708-119MG","article-title":"Adherence to continuous positive airway pressure therapy: the challenge to effective treatment","volume":"5","author":"Weaver","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.amjcard.2016.12.034_bib26","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1152\/japplphysiol.00587.2005","article-title":"Excess weight and sleep-disordered breathing","volume":"99","author":"Young","year":"2005","journal-title":"J\u00a0Appl Physiol (1985)"},{"key":"10.1016\/j.amjcard.2016.12.034_bib27","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.sleep.2014.05.012","article-title":"Weight loss from lifestyle interventions and severity of sleep apnoea: a systematic review and meta-analysis","volume":"15","author":"Mitchell","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.amjcard.2016.12.034_bib28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/ATVBAHA.112.300346","article-title":"Pioglitazone slows progression of atherosclerosis in prediabetes independent of changes in cardiovascular risk factors","volume":"33","author":"Saremi","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2016.12.034_bib29","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4158\/EP.9.5.406","article-title":"Thiazolidinediones, peripheral edema, and type 2 diabetes: incidence, pathophysiology, and clinical implications","volume":"9","author":"Mudaliar","year":"2003","journal-title":"Endocr Pract"},{"key":"10.1016\/j.amjcard.2016.12.034_bib30","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1345\/aph.1K286","article-title":"Effects of thiazolidinediones on bone loss and fracture","volume":"41","author":"Murphy","year":"2007","journal-title":"Ann Pharmacother"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914917300590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914917300590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T12:43:43Z","timestamp":1601469823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914917300590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0002914917300590"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2016.12.034","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Pioglitazone on Cardiometabolic Risk in Patients With Obstructive Sleep Apnea","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2016.12.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}