{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:33:06Z","timestamp":1787315586786,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajconline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.amjcard.2017.03.033","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:03:29Z","timestamp":1490745809000},"page":"2035-2041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Usefulness of the Direct and\/or Total Bilirubin to Predict Adverse Outcomes in Patients With Acute Decompensated Heart Failure"],"prefix":"10.1016","volume":"119","author":[{"given":"Atsushi","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Sugano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotsugu","family":"Iwakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Takashio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Asaumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Kusano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Anzai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsufumi","family":"Motokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Hamatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiro","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Chinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinatsu","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Maruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Sumita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2017.03.033_bib1","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.jacc.2013.03.042","article-title":"Cardiohepatic interactions in heart failure: an overview and clinical implications","volume":"61","author":"Samsky","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2017.03.033_bib2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/eurheartj\/ehs332","article-title":"Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure","volume":"34","author":"Nikolaou","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2017.03.033_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/2048872612474906","article-title":"The predictive value of transaminases at admission in patients hospitalized for heart failure: findings from the RO-AHFS registry","volume":"2","author":"Ambrosy","year":"2013","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.amjcard.2017.03.033_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.20452\/pamw.1413","article-title":"Liver function tests in patients with acute heart failure","volume":"122","author":"Biegus","year":"2012","journal-title":"Pol Arch Med Wewn"},{"key":"10.1016\/j.amjcard.2017.03.033_bib5","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1253\/circj.CJ-09-0498","article-title":"A\u00a0simple risk score to predict in-hospital death of elderly patients with acute decompensated heart failure\u2014hypoalbuminemia as an additional prognostic factor","volume":"73","author":"Kinugasa","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.amjcard.2017.03.033_bib6","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.ahj.2010.09.004","article-title":"Serum albumin and mortality in acutely decompensated heart failure","volume":"160","author":"Uthamalingam","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2017.03.033_bib7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1253\/circj.CJ-15-1326","article-title":"Prognostic value of prothrombin time international normalized ratio in acute decompensated heart failure\u2014a combined marker of hepatic insufficiency and hemostatic abnormality","volume":"80","author":"Okada","year":"2016","journal-title":"Circ J"},{"key":"10.1016\/j.amjcard.2017.03.033_bib8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cardfail.2014.03.003","article-title":"Liver function, in-hospital, and post-discharge clinical outcome in patients with acute heart failure-results from the relaxin for the treatment of patients with acute heart failure study","volume":"20","author":"van Deursen","year":"2014","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.amjcard.2017.03.033_bib9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/eurjhf\/hfs007","article-title":"Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial","volume":"14","author":"Ambrosy","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2017.03.033_bib10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cardfail.2014.05.001","article-title":"Longitudinal trends, hemodynamic profiles, and prognostic value of abnormal liver function tests in patients with acute decompensated heart failure: an analysis of the ESCAPE trial","volume":"20","author":"Scholfield","year":"2014","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.amjcard.2017.03.033_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1253\/circj.72.364","article-title":"Prognostic significance of increased serum bilirubin levels coincident with cardiac decompensation in chronic heart failure","volume":"72","author":"Shinagawa","year":"2008","journal-title":"Circ J"},{"key":"10.1016\/j.amjcard.2017.03.033_bib12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5507\/bp.2014.014","article-title":"Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure","volume":"159","author":"Vyskocilova","year":"2015","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.amjcard.2017.03.033_bib13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3904\/kjim.2013.28.3.300","article-title":"Serum bilirubin as a prognostic marker in patients with acute decompensated heart failure","volume":"28","author":"Chintanaboina","year":"2013","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.amjcard.2017.03.033_bib14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/ejhf.537","article-title":"Prognostic significance of endogenous erythropoietin in long-term outcome of patients with acute decompensated heart failure","volume":"18","author":"Nagai","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2017.03.033_bib15","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1161\/CIRCULATIONAHA.105.610642","article-title":"Drawbacks and prognostic value of formulas estimating renal function in patients with chronic heart failure and systolic dysfunction","volume":"114","author":"Smilde","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2017.03.033_bib16","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.amjcard.2017.03.033_bib17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.amjcard.2017.03.033_bib18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.amjcard.2017.03.033_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cardfail.2009.08.002","article-title":"Abnormal liver function in relation to hemodynamic profile in heart failure patients","volume":"16","author":"van Deursen","year":"2010","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.amjcard.2017.03.033_bib20","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1055\/s-2008-1068222","article-title":"Prevalence of Gilbert's syndrome in Germany","volume":"112","author":"Sieg","year":"1987","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.amjcard.2017.03.033_bib21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/jmg.12.2.152","article-title":"Population studies on Gilbert's syndrome","volume":"12","author":"Owens","year":"1975","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.amjcard.2017.03.033_bib22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/eurjhf\/hfn031","article-title":"Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program","volume":"11","author":"Allen","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2017.03.033_bib23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1067\/mhj.2000.107177","article-title":"Heart diseases affecting the liver and liver diseases affecting the heart","volume":"140","author":"Naschitz","year":"2000","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2017.03.033_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11897-014-0238-0","article-title":"Cardiohepatic syndrome","volume":"12","author":"Poelzl","year":"2015","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.amjcard.2017.03.033_bib25","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1093\/eurheartj\/eht246","article-title":"Interactions of the heart and the liver","volume":"34","author":"Moller","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2017.03.033_bib26","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/CIRCULATIONAHA.112.105775","article-title":"Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome","volume":"126","author":"Maruhashi","year":"2012","journal-title":"Circulation"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914917303570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914917303570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T15:06:36Z","timestamp":1750172796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914917303570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0002914917303570"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2017.03.033","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Usefulness of the Direct and\/or Total Bilirubin to Predict Adverse Outcomes in Patients With Acute Decompensated Heart Failure","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2017.03.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}