{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:01:14Z","timestamp":1793221274951,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T00:00:00Z","timestamp":1567814400000},"content-version":"am","delay-in-days":402,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG034676"],"award-info":[{"award-number":["R01AG034676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.amjcard.2018.04.049","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T10:23:23Z","timestamp":1526379803000},"page":"597-603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Usefulness of the Addition of Renal Function to the CHA2DS2-VASc Score as a Predictor of Thromboembolism and Mortality in Patients Without Atrial Fibrillation"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-8195","authenticated-orcid":false,"given":"Christine","family":"Parsons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win-Kuang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna M.","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil Allen","family":"Luis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Keddis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Shamoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2018.04.049_bib0001","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0002","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1093\/eurheartj\/ehr488","article-title":"Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study","volume":"33","author":"Friberg","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0003","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJM198204293061703","article-title":"Epidemiologic features of chronic atrial fibrillation: the Framingham study","volume":"306","author":"Kannel","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0004","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.mayocp.2016.10.008","article-title":"CHA2DS2-VASc score: a predictor of thromboembolic events and mortality in patients with an implantable monitoring device without atrial fibrillation","volume":"92","author":"Parsons","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0005","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.amjcard.2015.08.049","article-title":"Stroke risk factors beyond the CHA(2)DS(2)-VASc score: can we improve our identification of \"high stroke risk\" patients with atrial fibrillation","volume":"116","author":"Szymanski","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0006","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1160\/TH13-01-0054","article-title":"Does chronic kidney disease improve the predictive value of the CHADS2 and CHA2DS2-VASc stroke stratification risk scores for atrial fibrillation","volume":"109","author":"Roldan","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0007","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/CIRCULATIONAHA.112.107128","volume":"127","author":"Piccini","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0008","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1093\/eurheartj\/ehw077","article-title":"Comparison of the ATRIA, CHADS2, and CHA2DS2-VASc stroke risk scores in predicting ischaemic stroke in a large Swedish cohort of patients with atrial fibrillation","volume":"37","author":"Aspberg","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0009","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1093\/ije\/dys195","article-title":"Data resource profile: the Rochester Epidemiology Project (REP) medical records-linkage system","volume":"41","author":"St Sauver","year":"2012","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0010","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.amjcard.2012.03.021","article-title":"Usefulness of continuous electrocardiographic monitoring for atrial fibrillation","volume":"110","author":"Camm","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0011","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000250","article-title":"A new risk scheme to predict ischemic stroke and other thromboembolism in atrial fibrillation: the ATRIA study stroke risk score","volume":"2","author":"Singer","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0012","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.semnephrol.2015.06.003","article-title":"Stroke and chronic kidney disease: epidemiology, pathogenesis, and management across kidney disease stages","volume":"35","author":"Dad","year":"2015","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0013","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1212\/WNL.0b013e318287281b","article-title":"CHADS(2), CHA(2)S(2)DS(2)-VASc, and long-term stroke outcome in patients without atrial fibrillation","volume":"80","author":"Ntaios","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0014","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000353670","article-title":"Pre-stroke CHADS2 and CHA2DS2-VASc scores are useful in stratifying three-month outcomes in patients with and without atrial fibrillation","volume":"36","author":"Tu","year":"2013","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/eurjhf\/hfr172","article-title":"Stroke aetiology and predictors of outcome in patients with heart failure and acute stroke: a 10-year follow-up study","volume":"14","author":"Vemmos","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0016","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jacc.2012.04.063","article-title":"Inflammation in atrial fibrillation","volume":"60","author":"Guo","year":"2012","journal-title":"J Am College Cardiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0017","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.amjcard.2009.02.053","article-title":"Relation of multiple inflammatory biomarkers to incident atrial fibrillation","volume":"104","author":"Schnabel","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0018","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.jacc.2015.03.557","article-title":"Fibrotic atrial cardiomyopathy, atrial fibrillation, and thromboembolism: mechanistic links and clinical inferences","volume":"65","author":"Hirsh","year":"2015","journal-title":"J Am College Cardiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0019","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa1105575","article-title":"Subclinical atrial fibrillation and the risk of stroke","volume":"366","author":"Healey","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0020","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/CIRCEP.109.849638","article-title":"The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk: the TRENDS study","volume":"2","author":"Glotzer","year":"2009","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0021","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1161\/CIRCULATIONAHA.113.007825","article-title":"Temporal relationship between subclinical atrial fibrillation and embolic events","volume":"129","author":"Brambatti","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0022","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/eurheartj\/ehv115","article-title":"Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices","volume":"36","author":"Martin","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0023","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1056\/NEJMoa021328","article-title":"Atrial fibrillation follow-up investigation of rhythm management I. A comparison of rate control and rhythm control in patients with atrial fibrillation","volume":"347","author":"Wyse","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0024","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.hrthm.2011.11.013","article-title":"Long-term effects of catheter ablation for lone atrial fibrillation: progressive atrial electroanatomic substrate remodeling despite successful ablation","volume":"9","author":"Teh","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0025","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1540-8167.2012.02341.x","article-title":"Fibrotic atrial cardiomyopathy: a specific disease\/syndrome supplying substrates for atrial fibrillation, atrial tachycardia, sinus node disease, AV node disease, and thromboembolic complications","volume":"23","author":"Kottkamp","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0026","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jacc.2010.09.049","article-title":"Association of left atrial fibrosis detected by delayed-enhancement magnetic resonance imaging and the risk of stroke in patients with atrial fibrillation","volume":"57","author":"Daccarett","year":"2011","journal-title":"J Am College Cardiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0027","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.2147\/TCRM.S94955","article-title":"Association of epicardial adipose tissue thickness and inflammation parameters with CHA2DS2-VASASc score in patients with nonvalvular atrial fibrillation","volume":"11","author":"Akdag","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0028","first-page":"22","article-title":"Anticoagulation in patients at high risk of stroke without documented atrial fibrillation. Time for a paradigm shift?","author":"Bayes de Luna","year":"2017","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1016\/j.amjcard.2018.04.049_bib0029","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/clc.22081","article-title":"Novel oral anticoagulants in atrial fibrillation: a meta-analysis of large, randomized, controlled trials vs warfarin","volume":"36","author":"Dogliotti","year":"2013","journal-title":"Clin Cardiol"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914918310506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914918310506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:28:34Z","timestamp":1757572114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914918310506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0002914918310506"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2018.04.049","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Usefulness of the Addition of Renal Function to the CHA2DS2-VASc Score as a Predictor of Thromboembolism and Mortality in Patients Without Atrial Fibrillation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2018.04.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}