{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:26:17Z","timestamp":1780086377449,"version":"3.54.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.amjcard.2020.03.013","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T10:53:11Z","timestamp":1585824791000},"page":"1906-1912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect at One Year of Adjuvant Trastuzumab for HER2+ Breast Cancer Combined with Radiation or an Anthracycline on Left Ventricular Ejection Fraction"],"prefix":"10.1016","volume":"125","author":[{"given":"Mousumi M.","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diandra","family":"Ayala-Peacock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banks W.","family":"Kooken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-8395","authenticated-orcid":false,"suffix":"Jr.","given":"Ralph B.","family":"D'Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1001-1849","authenticated-orcid":false,"given":"Jennifer H.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujethra","family":"Vasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-2229","authenticated-orcid":false,"given":"Alexandra","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi D.","family":"Klepin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-3759","authenticated-orcid":false,"given":"Doris R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Gregory","family":"Hundley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2020.03.013_bib0001","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/cncr.10854","article-title":"Trastuzumab-associated cardiotoxicity","volume":"95","author":"Keefe","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0002","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1200\/JCO.2004.01.120","article-title":"Clinical cardiac tolerability of trastuzumab","volume":"22","author":"Perez","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0003","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11739-015-1362-x","article-title":"Risk of severe cardiotoxicity following treatment with trastuzumab: A meta-analysis of randomized and cohort studies of 29,000 women with breast cancer","volume":"11","author":"Mantarro","year":"2016","journal-title":"Intern Emerg Med"},{"issue":"2","key":"10.1016\/j.amjcard.2020.03.013_bib0004","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2478\/raon-2013-0040","article-title":"Cardiotoxicity of concomitant radiotherapy and trastuzumab for early breast cancer","volume":"48","author":"Marinko","year":"2014","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10549-018-5053-y","article-title":"Evaluation of radiation-induced cardiac toxicity in breast cancer patients treated with Trastuzumab-based chemotherapy","volume":"174","author":"Abouegylah","year":"2019","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0006","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1177\/0960327116680276","article-title":"Assessment of concomitant versus sequential trastuzumab on radiation-induced cardiovascular toxicity","volume":"36","author":"Yavas","year":"2017","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0007","doi-asserted-by":"crossref","unstructured":"Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 report 2003; JAMA289:2560-2572.","DOI":"10.1097\/00132578-200307000-00027"},{"issue":"Suppl 1","key":"10.1016\/j.amjcard.2020.03.013_bib0008","first-page":"S62","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0009","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIR.0000000000000095","volume":"130","author":"Fihn","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0010","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0011","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.amjcard.2017.02.008","article-title":"Frequency of left ventricular end-diastolic volume-mediated declines in ejection faction in patients receiving potentially cardiotoxic cancer treatment","volume":"119","author":"Melendez","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0012","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0002-9149(81)90213-7","article-title":"Direct measurement of cardiac output by gated equilibrium blood pool scintigrpahy: Validation of scintigraphic volume measurements by a nongeometric technique","volume":"47","author":"Dehmer","year":"1981","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0013","first-page":"70","article-title":"Trastuzumab-induced cardiac dysfunction: A 'dual-hit'","volume":"16","author":"Zeglinski","year":"2011","journal-title":"Exp Clin Cardiol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0014","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/01.CIR.0000013839.41224.1C","article-title":"Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: Potential mechanism for trastuzumab-induced cardiotoxicity","volume":"105","author":"Sawyer","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0015","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1200\/JCO.2005.13.300","article-title":"Reversibility of trastuzumab-related cardiotoxicity: New insights based on clinical course and response to medical treatment","volume":"23","author":"Ewer","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0016","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/eci.12589","article-title":"Update on cardiotoxicity of anti\u2010cancer treatments","volume":"46","author":"Rosa","year":"2016","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0017","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0018","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1200\/JCO.2007.14.9401","article-title":"Anthracycline cardiotoxicity: From bench to bedside","volume":"26","author":"Gianni","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0019","first-page":"9","article-title":"Myocyte survival pathways and cardiomyopathy: Implications for trastuzumab cardiotoxicity","volume":"27","author":"Chien","year":"2000","journal-title":"Semin Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0020","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/annonc\/mdn029","article-title":"Concurrent trastuzumab with adjuvant radiotherapy in HER2-positive breast cancer patients: Acute toxicity analyses from the French multicentric study","volume":"19","author":"Belkacemi","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0021","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ijrobp.2015.07.2287","article-title":"Cardiac function after multimodal breast cancer therapy assessed with functional magnetic resonance imaging and echocardiography imaging","volume":"93","author":"Heggemann","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0022","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/CIRCIMAGING.112.973321","article-title":"Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab","volume":"5","author":"Sawaya","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0023","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.radonc.2008.09.003","article-title":"Acute cardiotoxicity with concurrent trastuzumab and radiotherapy including internal mammary chain nodes: A retrospective single-institution study","volume":"90","author":"Shaffer","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0024","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1200\/JCO.2006.09.1611","article-title":"Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial","volume":"25","author":"Suter","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0025","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.1200\/JCO.2005.02.4091","volume":"23","author":"Tan-Chiu","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0026","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1200\/JCO.2008.17.9549","article-title":"Radiotherapy and adjuvant trastuzumab in operable breast cancer: Tolerability and adverse event data from the NCCTG Phase III Trial N9831","volume":"27","author":"Halyard","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0027","doi-asserted-by":"crossref","first-page":"7475","DOI":"10.1200\/JCO.2005.13.755","article-title":"Cardiac morbidity of adjuvant radiotherapy for breast cancer","volume":"23","author":"Patt","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0028","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/CIRCULATIONAHA.116.023463","article-title":"Detailed echocardiographic phenotyping in breast cancer patients: associations with ejection fraction decline, recovery, and heart failure symptoms over 3 years of follow-up","volume":"135","author":"Narayan","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2020.03.013_bib0029","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/CIRCHEARTFAILURE.111.965020","article-title":"Multiple biomarkers for risk prediction in chronic heart failure","volume":"5","author":"Ky","year":"2012","journal-title":"Circ Heart Fail"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914920302629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914920302629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:33:34Z","timestamp":1757572414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914920302629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0002914920302629"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2020.03.013","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect at One Year of Adjuvant Trastuzumab for HER2+ Breast Cancer Combined with Radiation or an Anthracycline on Left Ventricular Ejection Fraction","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2020.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}