{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:44:19Z","timestamp":1778953459610,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.amjcard.2020.07.038","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T02:59:32Z","timestamp":1595559572000},"page":"48-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Meta-Analysis of the Usefulness of Therapeutic Hypothermia After Cardiac Arrest"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-240X","authenticated-orcid":false,"given":"Amit","family":"Rout","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-782X","authenticated-orcid":false,"given":"Sahib","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sauradeep","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immad","family":"Munawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-8158","authenticated-orcid":false,"given":"Christopher R.","family":"D'Adamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udaya S.","family":"Tantry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-6119","authenticated-orcid":false,"given":"Ashwin","family":"Dharmadhikari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gurbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2020.07.038_bib0001","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000757","article-title":"American Heart Association Council on epidemiology and prevention statistics committee and stroke statistics subcommittee. Heart disease and stroke statistics-2020 update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0002","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.119.005580","article-title":"American Heart Association's get with the guidelines\u2014resuscitation investigators. Annual incidence of adult and pediatric in-hospital cardiac arrest in the United States","volume":"12","author":"Holmberg","year":"2019","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0003","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1405796","article-title":"Early cardiopulmonary resuscitation in out-of-hospital cardiac arrest","volume":"372","author":"Hasselqvist-Ax","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0004","unstructured":"https:\/\/mycares.net\/sitepages\/data. 2018Annual Report. Accessed on February 20, 2020."},{"key":"10.1016\/j.amjcard.2020.07.038_bib0005","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0006","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"Bernard","year":"2002","journal-title":"N Engl J Med"},{"issue":"18 suppl 3","key":"10.1016\/j.amjcard.2020.07.038_bib0007","first-page":"S768","article-title":"American Heart Association. Part 9: post-cardiac arrest care: 2010 American Heart Association Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"122","author":"Peberdy","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0008","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33\u00b0C versus 36\u00b0C after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"issue":"18 suppl 2","key":"10.1016\/j.amjcard.2020.07.038_bib0009","first-page":"S465","article-title":"Part 8: post-cardiac arrest care: 2015 American Heart Association Guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"132","author":"Callaway","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0010","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1161\/CIR.0000000000000313","volume":"132","author":"Donnino","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0011","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.4511","article-title":"Temporal trends in the use of therapeutic hypothermia for out-of-hospital cardiac arrest","volume":"1","author":"Bradley","year":"2018","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0012","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1056\/NEJMoa1906661","article-title":"Targeted temperature management for cardiac arrest with nonshockable rhythm","volume":"381","author":"Lascarrou","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0014","unstructured":"Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014."},{"key":"10.1016\/j.amjcard.2020.07.038_bib0015","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0300-9572(01)00412-9","article-title":"Mild hypothermia induced by a helmet device: a clinical feasibility study","volume":"51","author":"Hachimi-Idrissi","year":"2001","journal-title":"Resuscitation"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0016","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.resuscitation.2004.08.008","article-title":"The evolution of serum astroglial S-100 beta protein in patients with cardiac arrest treated with mild hypothermia","volume":"64","author":"Hachimi-Idrissi","year":"2005","journal-title":"Resuscitation"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0017","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jacc.2005.04.039","article-title":"High-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study","volume":"46","author":"Laurent","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0018","first-page":"A168","article-title":"A multivariate analysis of prognostic factors in survivors of out-of-hospital cardiac arrest with brain hypothermia","volume":"28","author":"Mori","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0019","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijcard.2010.06.008","article-title":"Hypothermia after cardiac arrest should be further evaluated\u2014a systematic review of randomised trials with meta-analysis and trial sequential analysis","volume":"151","author":"Nielsen","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0020","article-title":"Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation","volume":"2","author":"Arrich","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0021","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s13054-015-1133-0","article-title":"The effect of mild induced hypothermia on outcomes of patients after cardiac arrest: a systematic review and meta-analysis of randomised controlled trials","volume":"19","author":"Zhang","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0022","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jama.2016.14380","article-title":"Association between therapeutic hypothermia and survival after in-hospital cardiac arrest","volume":"316","author":"Chan","year":"2016","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.amjcard.2020.07.038_bib0023","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/CIRCULATIONAHA.117.029656","article-title":"Confusion around therapeutic temperature management hypothermia after in-hospital cardiac arrest?","volume":"137","author":"Polderman","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0024","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.amjmed.2015.11.004","article-title":"Use of targeted temperature management after out-of-hospital cardiac arrest: a meta-analysis of randomized controlled trials","volume":"129","author":"Mahmoud","year":"2016","journal-title":"Am J Med"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.resuscitation.2016.07.238","article-title":"Therapeutic hypothermia after cardiac arrest: a systematic review\/meta-analysis exploring the impact of expanded criteria and targeted temperature","volume":"108","author":"Schenone","year":"2016","journal-title":"Resuscitation"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0026","article-title":"Targeted temperature management after cardiac arrest: updated meta-analysis of all-cause mortality and neurological outcomes","volume":"24","author":"Abdalla","year":"2019","journal-title":"Int J Cardiol Heart Vasc"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0027","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/CCM.0000000000004159","article-title":"Targeted temperature management at 33 versus 36 degrees: a retrospective cohort study","volume":"48","author":"Johnson","year":"2020","journal-title":"Crit Care Med"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0028","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ahj.2019.06.012","article-title":"Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2): a randomized clinical trial-Rationale and design","volume":"217","author":"Dankiewicz","year":"2019","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjcard.2020.07.038_bib0029","unstructured":"Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest (TTM-2). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02908308. Accessed on February 20, 2020."}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914920307724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914920307724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:35:23Z","timestamp":1757572523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914920307724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":29,"alternative-id":["S0002914920307724"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2020.07.038","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-Analysis of the Usefulness of Therapeutic Hypothermia After Cardiac Arrest","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2020.07.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}