{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:59:18Z","timestamp":1792202358132,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.amjcard.2021.02.030","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T16:50:58Z","timestamp":1614790258000},"page":"8-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Exercise Preconditioning as a Cardioprotective Phenotype"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-0086","authenticated-orcid":false,"given":"John C.","family":"Quindry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2021.02.030_bib0001","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0002","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1161\/01.RES.0000137171.97172.d7","article-title":"Myocardial protection at a crossroads: the need for translation into clinical therapy","volume":"95","author":"Bolli","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0003","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.freeradbiomed.2007.02.006","article-title":"Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury","volume":"44","author":"Powers","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0004","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/1074248417715005","article-title":"Exercise-induced cardioprotection and the therapeutic potential of RIPC","volume":"22","author":"Quindry","year":"2017","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1249\/JES.0000000000000134","article-title":"Cardioprotective exercise and pharmacologic interventions as complementary antidotes to cardiovascular disease","volume":"46","author":"Quindry","year":"2018","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0006","doi-asserted-by":"crossref","first-page":"H1423","DOI":"10.1152\/ajpheart.00850.2014","article-title":"Interleukin-6 mediates exercise preconditioning against myocardial ischemia reperfusion injury","volume":"308","author":"McGinnis","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0007","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1113\/expphysiol.2014.083436","article-title":"Involvement of the \u03b4-opioid receptor in exercise-induced cardioprotection","volume":"100","author":"Miller","year":"2015","journal-title":"Exp Physiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0008","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.yjmcc.2004.05.028","article-title":"Duality of innate stress responses in cardiac injury, repair, and remodeling","volume":"37","author":"Wilson","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0009","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1152\/jappl.2001.91.5.2205","article-title":"Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat","volume":"91","author":"Demirel","year":"2001","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0010","first-page":"R1468","article-title":"Exercise training improves myocardial tolerance to in vivo ischemia-reperfusion in the rat","volume":"275","author":"Powers","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0011","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1084\/jem.189.11.1699","article-title":"Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation","volume":"189","author":"Yamashita","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0012","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1152\/japplphysiol.00920.2003","article-title":"Loss of exercise-induced cardioprotection after cessation of exercise","volume":"96","author":"Lennon","year":"2004","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0013","first-page":"27","article-title":"Mechanisms of exercise-induced cardioprotection","volume":"29","author":"Powers","year":"2014","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0014","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/01.hjr.0000159319.62466.95","article-title":"Habitual low-intensity exercise does not protect against myocardial dysfunction after ischemia in rats","volume":"12","author":"Starnes","year":"2005","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-201X.2004.01346.x","article-title":"Exercise and myocardial tolerance to ischaemia-reperfusion","volume":"182","author":"Lennon","year":"2004","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0016","doi-asserted-by":"crossref","first-page":"H1020","DOI":"10.1152\/ajpheart.00156.2005","article-title":"Acute exercise increases the ventricular arrhythmia threshold via the intrinsic adenosine receptor system in conscious hypertensive rats","volume":"289","author":"Collins","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0017","doi-asserted-by":"crossref","first-page":"H532","DOI":"10.1152\/ajpheart.00873.2004","article-title":"Daily exercise-induced cardioprotection is associated with changes in calcium regulatory proteins in hypertensive rats","volume":"288","author":"Collins","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0018","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1152\/japplphysiol.00525.2010","article-title":"Strain screen and haplotype association mapping of wheel running in inbred mouse strains","volume":"109","author":"Lightfoot","year":"2010","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0019","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1113\/EP086091","article-title":"Long-term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice","volume":"102","author":"Ballmann","year":"2017","journal-title":"Exp Physiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0020","doi-asserted-by":"crossref","first-page":"H128","DOI":"10.1152\/ajpheart.00552.2016","article-title":"Lifelong quercetin enrichment and cardioprotection in Mdx\/Utrn+\/- mice","volume":"312","author":"Ballmann","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0021","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.exger.2005.03.010","article-title":"Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals","volume":"40","author":"Quindry","year":"2005","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0022","doi-asserted-by":"crossref","first-page":"H2432","DOI":"10.1152\/ajpheart.01301.2006","article-title":"Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart","volume":"292","author":"Chicco","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0023","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1249\/MSS.0b013e3182323f8b","article-title":"Evaluation of arrhythmia scoring systems and exercise-induced cardioprotection","volume":"44","author":"Miller","year":"2012","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0024","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.2105\/AJPH.61.7.1362","article-title":"Characteristics of longshoremen related fatal coronary heart disease and stroke","volume":"61","author":"Paffenbarger","year":"1971","journal-title":"Am J Public Health"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0025","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.jacc.2008.01.053","article-title":"Physical activity status and acute coronary syndromes survival The GREECS (Greek Study of Acute Coronary Syndromes) study","volume":"51","author":"Pitsavos","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0026","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1001\/jamacardio.2017.4495","article-title":"Association of exercise preconditioning with immediate cardioprotection: a review","volume":"3","author":"Thijssen","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0027","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/2047487313502447","article-title":"Exercise-induced ischemic preconditioning detected by sequential exercise stress tests: a meta-analysis","volume":"22","author":"Lalonde","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0028","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/hrt.81.4.404","article-title":"Effect of repetitive episodes of exercise induced myocardial ischaemia on left ventricular function in patients with chronic stable angina: evidence for cumulative stunning or ischaemic preconditioning?","volume":"81","author":"Rinaldi","year":"1999","journal-title":"Heart"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0029","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2174\/1573403X10666140404110229","article-title":"Cardioprotection acquired through exercise: the role of ischemic preconditioning","volume":"10","author":"Marongiu","year":"2014","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0030","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1053\/euhj.1998.1311","article-title":"Effects of K(ATP) channel blockade by glibenclamide on the warm-up phenomenon","volume":"20","author":"Tomai","year":"1999","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0031","series-title":"Physical Activity Guidelines for Americans","year":"2018"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0032","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/00005768-200105000-00012","article-title":"Physical fitness and activity as separate heart disease risk factors: a meta-analysis","volume":"33","author":"Williams","year":"2001","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0033","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1161\/CIRCULATIONAHA.114.007641","article-title":"Preventing exercise-related cardiovascular events: is a medical examination more urgent for physical activity or inactivity?","volume":"129","author":"Franklin","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0034","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1056\/NEJM199312023292301","article-title":"Triggering of acute myocardial infarction by heavy physical exertion. Protection against triggering by regular exertion. Determinants of Myocardial Infarction Onset Study Investigators","volume":"329","author":"Mittleman","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0035","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.amjcard.2006.08.053","article-title":"Comparison of left ventricular ejection fraction and exercise capacity as predictors of two- and five-year mortality following acute myocardial infarction","volume":"99","author":"Dutcher","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0036","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.amjcard.2019.01.008","article-title":"Benefits and risks of high-intensity interval training in patients with coronary artery disease","volume":"123","author":"Quindry","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2021.02.030_bib0037","series-title":"Biochemistry of Exercise","article-title":"Biochemistry of exercise training and mitigation of cardiovascular disease","author":"Franklin","year":"2021"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914921002058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914921002058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:38:23Z","timestamp":1757572703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914921002058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":37,"alternative-id":["S0002914921002058"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2021.02.030","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise Preconditioning as a Cardioprotective Phenotype","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2021.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}