{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:11:00Z","timestamp":1778649060800,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100001340","name":"W. W. Smith Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL47678"],"award-info":[{"award-number":["HL47678"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL152201"],"award-info":[{"award-number":["HL152201"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL138103"],"award-info":[{"award-number":["HL138103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.amjcard.2021.04.010","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T05:32:18Z","timestamp":1621834338000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern"],"prefix":"10.1016","volume":"151","author":[{"given":"Anil S.","family":"Sarica","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhat","family":"Bor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-9329","authenticated-orcid":false,"given":"Mehmet N.","family":"Orman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Barajas-Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh-Ming Jimmy","family":"Juang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Antzelevitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Hasdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2021.04.010_bib0001","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0002","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0003","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.gtc.2010.12.011","article-title":"The role of genetics in IBS","volume":"40","author":"Saito","year":"2011","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0004","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report","volume":"20","author":"Brugada","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0005","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1016\/j.hrthm.2016.05.024","article-title":"J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge","volume":"13","author":"Antzelevitch","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0006","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1053\/j.gastro.2014.02.054","article-title":"Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome","volume":"146","author":"Beyder","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0007","doi-asserted-by":"crossref","first-page":"e13358","DOI":"10.1111\/nmo.13358","article-title":"A GWAS meta-analysis from 5 population-based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome","volume":"30","author":"Bonfiglio","year":"2018","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0008","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.hrthm.2015.03.015","article-title":"High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia","volume":"12","author":"Hasdemir","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0009","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/pace.13414","article-title":"Coexistence of atrioventricular accessory pathways and drug-induced type 1 Brugada pattern","volume":"41","author":"Hasdemir","year":"2018","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0010","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","volume":"150","author":"Lacy","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0011","doi-asserted-by":"crossref","first-page":"386","DOI":"10.5152\/tjg.2014.4774","article-title":"The Turkish version of the Rome III criteria for IBS is valid and reliable","volume":"25","author":"Ozgursoy Uran","year":"2014","journal-title":"Turk J Gastroenterol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0012","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.hrthm.2009.07.002","article-title":"Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)","volume":"6","author":"Postema","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0013","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/CIRCULATIONAHA.120.050587","article-title":"Cardiovascular toxicities associated with loperamide: analysis of the world health organization pharmacovigilance database","volume":"143","author":"Ollitrault","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0014","article-title":"Increased prevalence of irritable bowel syndrome in migraine patients: a systematic review and meta-analysis","author":"Wongtrakul","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0015","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1111\/jce.14778","article-title":"Recognition and clinical implications of high prevalence of migraine in patients with Brugada syndrome and drug-induced type 1 Brugada pattern","volume":"31","author":"Hasdemir","year":"2020","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0016","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1365-2982.2007.01077.x","article-title":"Irritable bowel syndrome aggregates strongly in families: a family-based case-control study","volume":"20","author":"Saito","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0017","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/gutjnl-2013-305705","article-title":"Risk of irritable bowel syndrome in first-degree, second-degree and third-degree relatives of affected individuals: a nationwide family study in Sweden","volume":"64","author":"Waehrens","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0018","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/ng.2712","article-title":"Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death","volume":"45","author":"Bezzina","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0019","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jjcc.2019.01.009","article-title":"Recent understanding of clinical sequencing and gene-based risk stratification in inherited primary arrhythmia syndrome","volume":"73","author":"Aiba","year":"2019","journal-title":"J Cardiol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0020","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/nmo.12569","article-title":"The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders","volume":"27","author":"Verstraelen","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0021","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1572-0241.2006.00507.x","article-title":"Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: evidence of an intestinal channelopathy","volume":"101","author":"3rd","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/S0016-5085(08)63187-X","article-title":"Abdominal symptoms in patients with long QT syndrome and a \u201cgain of function\u201d mutation in the Nav1.5 sodium channel","volume":"134","author":"Braak","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0023","doi-asserted-by":"crossref","first-page":"G211","DOI":"10.1152\/ajpgi.90571.2008","article-title":"Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy","volume":"296","author":"Saito","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0024","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5056\/jnm.2012.18.1.58","article-title":"The relationship between gastric myoelectric activity and SCN5A mutation suggesting sodium channelopathy in patients with brugada syndrome and functional dyspepsia - a pilot study","volume":"18","author":"Jung","year":"2012","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0025","doi-asserted-by":"crossref","first-page":"G581","DOI":"10.1152\/ajpgi.00237.2016","article-title":"Ion channelopathies in functional GI disorders","volume":"311","author":"Beyder","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0026","doi-asserted-by":"crossref","first-page":"G494","DOI":"10.1152\/ajpgi.00016.2017","article-title":"Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity","volume":"314","author":"Strege","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.amjcard.2021.04.010_bib0027","article-title":"Transcriptome of interstitial cells of Cajal reveals unique and selective gene signatures","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS One"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914921003635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914921003635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:32:30Z","timestamp":1778646750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914921003635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":27,"alternative-id":["S0002914921003635"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2021.04.010","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2021.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}