{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:18:08Z","timestamp":1777443488628,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.amjcard.2022.02.050","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T09:18:14Z","timestamp":1648718294000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Serum Levels of Cholesterol and Lipoproteins in Patients With Symptomatic Paravalvular Leaks"],"prefix":"10.1016","volume":"173","author":[{"given":"Ahmet","family":"G\u00fcner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macit","family":"Kal\u00e7\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Ozan","family":"G\u00fcrsoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabahattin","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev","family":"K\u0131l\u0131\u00e7gedik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emrah","family":"Bayam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semih","family":"Kalkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cevat","family":"K\u0131rma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhsin","family":"T\u00fcrkmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylan","family":"Adademir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-7890","authenticated-orcid":false,"given":"Mehmet","family":"Aks\u00fct","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Fedakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaan","family":"K\u0131rali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2022.02.050_bib0001","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1016\/j.jacc.2017.02.038","article-title":"Paravalvular Leak Academic Research Consortium. Clinical trial principles and endpoint definitions for paravalvular leaks in surgical prosthesis: an expert statement","volume":"69","author":"Ruiz","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0002","first-page":"350","article-title":"A comprehensive review of the diagnosis and management of mitral paravalvular leakage","volume":"24","author":"G\u00fcrsoy","year":"2020","journal-title":"Anatol J Cardiol"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0003","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/eurheartj\/ehs347","article-title":"Review of surgical prosthetic paravalvular leaks: diagnosis and catheter-based closure","volume":"34","author":"Kliger","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0004","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12944-019-1174-5","article-title":"Altered HDL particle in sickle cell disease: decreased cholesterol content is associated with hemolysis, whereas decreased apolipoprotein A1 is linked to inflammation","volume":"18","author":"Yalcinkaya","year":"2019","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0005","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1177\/1535370216657447","article-title":"Featured article: alterations of lecithin cholesterol acyltransferase activity and apolipoprotein AI functionality in human sickle blood","volume":"241","author":"Soupene","year":"2016","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0006","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cca.2020.03.003","article-title":"Serum haptoglobin correlates positively with cholesterol and triglyceride concentrations in an obese Mongolian population","volume":"505","author":"Soejima","year":"2020","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0007","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension [published correction appears in Eur Heart J 2019;40:475]","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0008","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0009","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes [published correction appears in Eur Heart J 2020;41:4242]","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0010","doi-asserted-by":"crossref","first-page":"e3197","DOI":"10.1002\/dmrr.3197","article-title":"Risk of end-stage renal disease from chronic kidney disease defined by decreased glomerular filtration rate in type 1 diabetes: a comparison with type 2 diabetes and the effect of metabolic syndrome","volume":"35","author":"Lee","year":"2019","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0011","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.echo.2009.07.013","volume":"22","author":"Zoghbi","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0012","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.115.001945","article-title":"Techniques and outcomes for the treatment of paravalvular leak","volume":"8","author":"Eleid","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0013","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.jcin.2016.08.038","article-title":"Techniques and outcomes of percutaneous aortic paravalvular leak closure","volume":"9","author":"Alkhouli","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0014","first-page":"307","article-title":"Closure of mitral paravalvular defects without performing an arteriovenous loop: a case series of fourteen patients","volume":"13","author":"Kilicgedik","year":"2017","journal-title":"Postepy Kardiol Interwencyjnej"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0015","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jacl.2018.08.002","article-title":"Differences in heme and hemopexin content in lipoproteins from patients with sickle cell disease","volume":"12","author":"Vendrame","year":"2018","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0016","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1111\/j.1742-4658.2009.07319.x","article-title":"Haptoglobin binds the antiatherogenic protein apolipoprotein E - impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes","volume":"276","author":"Cigliano","year":"2009","journal-title":"FEBS J"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0017","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1074\/jbc.M411390200","article-title":"Assignment of the binding site for haptoglobin on apolipoprotein A-I","volume":"280","author":"Spagnuolo","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0018","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0021-9150(98)00330-X","article-title":"Associations between haptoglobin polymorphism, lipids, lipoproteins and inflammatory variables","volume":"143","author":"Braeckman","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0019","doi-asserted-by":"crossref","first-page":"11158","DOI":"10.1021\/bi7006349","article-title":"Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase","volume":"46","author":"Salvatore","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0020","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s11745-013-3849-4","article-title":"Lipoprotein subfraction profile and HDL-associated enzymes in sickle cell disease patients","volume":"48","author":"Ozturk","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0021","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-0609.2008.01195.x","article-title":"Hypocholesterolemia in adult patients with thalassemia: a link with the severity of genotype in thalassemia intermedia patients","volume":"82","author":"Ricchi","year":"2009","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0022","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1365-2141.2010.08109.x","article-title":"Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension","volume":"149","author":"Zorca","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0023","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1476-511X-9-91","article-title":"Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease","volume":"9","author":"Seixas","year":"2010","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0024","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1177\/1535370217706966","article-title":"Featured article: depletion of HDL3 high density lipoprotein and altered functionality of HDL2 in blood from sickle cell patients","volume":"242","author":"Soupene","year":"2017","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0025","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1056\/NEJMoa1505643","article-title":"Von Willebrand factor multimers during transcatheter aortic-valve replacement","volume":"375","author":"Van Belle","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0026","doi-asserted-by":"crossref","unstructured":"Teis A, Castelblanco E, Cediel G, Amig\u00f3 N, Julve J, Ribalta J, Guardiola M, Franch J, Berm\u00fadez-L\u00f3pez M, Codina P, Lup\u00f3n J, Mauricio D, Alonso N, Bay\u00e9s-Gen\u00eds A. 1H-magnetic resonance spectroscopy lipoprotein profile in patients with chronic heart failure versus matched controls [published online October 26, 2021]. Rev Esp Cardiol (Engl Ed) doi:10.1016\/j.rec.2021.09.008.","DOI":"10.1016\/j.rec.2021.09.008"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0027","doi-asserted-by":"crossref","first-page":"46642","DOI":"10.1038\/srep46642","article-title":"Serum concentration of HDL particles predicts mortality in acute heart failure patients","volume":"7","author":"Poto\u010dnjak","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0028","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.ecl.2014.08.001","article-title":"Beginning to understand high-density lipoproteins","volume":"43","author":"Santos-Gallego","year":"2014","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.amjcard.2022.02.050_bib0029","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s11883-011-0177-0","article-title":"Experimental models for the investigation of high-density lipoprotein-mediated cholesterol efflux","volume":"13","author":"Santos-Gallego","year":"2011","journal-title":"Curr Atheroscler Rep"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291492200251X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291492200251X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:42:22Z","timestamp":1757572942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291492200251X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":29,"alternative-id":["S000291492200251X"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2022.02.050","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Levels of Cholesterol and Lipoproteins in Patients With Symptomatic Paravalvular Leaks","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2022.02.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}