{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:40:56Z","timestamp":1773218456932,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.amjcard.2022.04.045","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T08:55:49Z","timestamp":1655196949000},"page":"28-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Preadmission Statin Treatment and Outcome in Patients Hospitalized With COVID-19"],"prefix":"10.1016","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-8030","authenticated-orcid":false,"given":"Marwan","family":"Saad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiz","family":"Imran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"Charles F.","family":"Sherrod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Aspry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amgad","family":"Mentias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athena","family":"Poppas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Dawn","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-7893","authenticated-orcid":false,"given":"Herbert D.","family":"Aronow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2022.04.045_bib0001","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/jamacardio.2020.1286","article-title":"Potential effects of coronaviruses on the cardiovascular system: a review","volume":"5","author":"Madjid","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0002","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/jamacardio.2020.1017","article-title":"Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19)","volume":"5","author":"Guo","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0003","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/jamacardio.2020.0950","article-title":"Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China","volume":"5","author":"Shi","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0004","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jacc.2020.06.068","article-title":"Cardiac troponin for assessment of myocardial injury in COVID-19: JACC review topic of the week","volume":"76","author":"Sandoval","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic effects of statins on the cardiovascular system","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0006","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/cpt.1095","article-title":"Rapid. A rapid (differential) effect of rosuvastatin and atorvastatin on high-sensitivity cardiac troponin-I in subjects with stable cardiovascular disease","volume":"104","author":"Bodde","year":"2018","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0007","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","article-title":"Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials","volume":"376","author":"Baigent","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0008","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/jama.285.13.1711","article-title":"Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial","volume":"285","author":"Schwartz","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0009","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/s41467-021-21553-1","article-title":"Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19","volume":"12","author":"Gupta","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0010","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ijid.2021.08.004","article-title":"Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients","volume":"110","author":"Diaz-Arocutipa","year":"2021","journal-title":"Int J Infect Dis"},{"issue":"25 Pt B","key":"10.1016\/j.amjcard.2022.04.045_bib0011","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.jacc.2013.11.002","volume":"63","author":"Stone","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0012","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jacc.2020.06.007","article-title":"Prevalence and impact of myocardial injury in patients hospitalized with COVID-19 infection","volume":"76","author":"Lala","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0013","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/1354750X.2020.1829056","article-title":"High sensitivity troponin-T for prediction of adverse events in patients with COVID-19","volume":"25","author":"Singh","year":"2020","journal-title":"Biomarkers"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0014","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJMra1808137","article-title":"Acute infection and myocardial infarction","volume":"380","author":"Musher","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241955","article-title":"Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review","volume":"15","author":"Izcovich","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0016","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.jacc.2019.02.018","article-title":"Type 2 myocardial infarction: JACC review topic of the week","volume":"73","author":"Sandoval","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0017","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/cvr\/cvaa078","article-title":"The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2","volume":"116","author":"Chen","year":"2020","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0018","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.jacc.2016.10.020","article-title":"High-sensitivity cardiac troponin, statin therapy, and risk of coronary heart disease","volume":"68","author":"Ford","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0019","doi-asserted-by":"crossref","first-page":"8080","DOI":"10.1038\/s41598-021-87668-z","article-title":"Pattern of inflammatory immune response determines the clinical course and outcome of COVID-19: unbiased clustering analysis","volume":"11","author":"Lee","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/physrev.00035.2020","article-title":"Inflammation and thrombosis in covid-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets","volume":"101","author":"Sriram","year":"2021","journal-title":"Physiol Rev"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0021","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.jacc.2021.08.021","article-title":"Investigating lipid-modulating agents for prevention or treatment of COVID-19: JACC state-of-the-art review","volume":"78","author":"Talasaz","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0022","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0023","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S2213-2600(18)30177-2","article-title":"Irish Critical Care Trials Group. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial","volume":"6","author":"Calfee","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0024","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.thromres.2020.04.024","article-title":"Humanitas COVID-19 Task Force. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy","volume":"191","author":"Lodigiani","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0025","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/jmv.25871","article-title":"C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early","volume":"92","author":"Tan","year":"2020","journal-title":"J Med Virol"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0026","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.thromres.2020.09.027","article-title":"Intermediate versus standard-dose prophylactic anticoagulation and statin therapy versus placebo in critically-ill patients with COVID-19: rationale and design of the INSPIRATION\/INSPIRATION-S studies","volume":"196","author":"Bikdeli","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0027","unstructured":"American College of Cardiology. ACC.21 presentation slides | INSPIRATION-S. Available at:https:\/\/www.acc.org\/education-and-meetings\/image-and-slide-gallery\/media-detail?id=9DF17809F35C4CA6B149C64C9D700AC6. Accessed on May 22, 2021."},{"key":"10.1016\/j.amjcard.2022.04.045_bib0028","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13293-021-00386-z","article-title":"Sex differences in a cohort of COVID-19 Italian patients hospitalized during the first and second pandemic waves","volume":"12","author":"Quaresima","year":"2021","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0029","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/01.CIR.0000137828.06205.87","article-title":"Randomized trial of atorvastatin for reduction of myocardial damage during coronary intervention: results from the ARMYDA (Atorvastatin for Reduction of MYocardial Damage during Angioplasty) study","volume":"110","author":"Pasceri","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2022.04.045_bib0030","unstructured":"ClinicalTrials.gov. Combination therapies to reduce carriage of SARS-Cov-2 and improve outcome of COVID-19 in Ivory Coast: a phase randomized IIb trial (INTENSE-COV]. Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04466241. Accessed on November 13, 2021."}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914922005215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914922005215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:41:55Z","timestamp":1757572915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914922005215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":30,"alternative-id":["S0002914922005215"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2022.04.045","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742200001.793594875","asserted-by":"object"}]},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preadmission Statin Treatment and Outcome in Patients Hospitalized With COVID-19","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2022.04.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}