{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:34:57Z","timestamp":1790710497634,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.amjcard.2022.07.036","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T06:25:51Z","timestamp":1662445551000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Outcomes in Patients With High Transmitral Gradient After Mitral Valve Transcatheter Edge-to-Edge Repair for Mitral Regurgitation"],"prefix":"10.1016","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-3006","authenticated-orcid":false,"given":"Francesco","family":"De Felice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Paolucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Musto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Cifarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Coletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Gabrielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Luca","family":"Bartorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Citro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Mongiardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Monteforte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Crimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Popolo","family":"Rubbio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2022.07.036_bib0001","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease: developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0002","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0003","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/CIRCULATIONAHA.120.053061","article-title":"Relationship between residual mitral regurgitation and clinical and quality-of-life outcomes after transcatheter and medical treatments in heart failure: COAPT trial","volume":"144","author":"Kar","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0004","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4244\/EIJV4I4A76","article-title":"Effect of percutaneous mitral repair with the MitraClip device on mitral valve area and gradient","volume":"4","author":"Herrmann","year":"2009","journal-title":"EuroIntervention"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0005","first-page":"821","article-title":"Mitral valve hemodynamic effects of percutaneous edge-to-edge repair with the MitraClip device for mitral regurgitation","volume":"68","author":"Herrmann","year":"2006","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0006","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jcin.2016.12.280","article-title":"Elevated mitral valve pressure gradient after MitraClip implantation deteriorates long-term outcome in patients with severe mitral regurgitation and severe heart failure","volume":"10","author":"Neuss","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0007","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jcin.2021.01.049","article-title":"Effect of mitral valve gradient after MitraClip on outcomes in secondary mitral regurgitation: results from the COAPT trial","volume":"14","author":"Halaby","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0008","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.carrev.2020.01.002","article-title":"Real-world safety and efficacy of transcatheter mitral valve repair with MitraClip: thirty-day results from the Italian Society of Interventional Cardiology (GISE) registry of transcatheter treatment of mitral valve regurgitation (GIOTTO)","volume":"21","author":"Bedogni","year":"2020","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0009","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0010","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jacc.2015.05.049","article-title":"Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the mitral valve Academic Research Consortium","volume":"66","author":"Stone","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0011","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.euje.2004.03.001","article-title":"Echocardiographic classification of chronic ischemic mitral regurgitation caused by restricted motion according to tethering pattern","volume":"5","author":"Agricola","year":"2004","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0012","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jcin.2022.01.281","article-title":"Prognostic value of increased mitral valve gradient after transcatheter edge-to-edge repair for primary mitral regurgitation","volume":"15","author":"Yoon","year":"2022","journal-title":"JACC Cardiovasc Intv"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0013","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/CIRCIMAGING.112.000688","article-title":"Functional significance of elevated mitral gradients after repair for degenerative mitral regurgitation","volume":"6","author":"Chan","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0014","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.jacc.2007.11.082","article-title":"Restrictive annuloplasty for ischemic mitral regurgitation may induce functional mitral stenosis","volume":"51","author":"Magne","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0015","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1161\/CIRCULATIONAHA.110.013037","article-title":"Osaka Cardiovascular Surgery Research (OSCAR) Group. Does stringent restrictive annuloplasty for functional mitral regurgitation cause functional mitral stenosis and pulmonary hypertension?","volume":"124","author":"Kainuma","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0016","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/ejcts\/ezz178","article-title":"Risk factors and clinical significance of elevated mitral valve gradient following valve repair for degenerative disease","volume":"5","author":"Tom\u0161i\u010d","year":"2020","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0017","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.amjcard.2018.06.050","article-title":"Effect of atrial fibrillation and mitral valve gradients on response to percutaneous mitral valve repair with the MitraClip system","volume":"122","author":"Spieker","year":"2018","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0018","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.011366","article-title":"Elevated mitral valve pressure gradient is predictive of long-term outcome after percutaneous edge-to-edge mitral valve repair in patients with degenerative mitral regurgitation (MR), but not in functional MR","volume":"8","author":"Patzelt","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0019","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jcin.2020.09.050","article-title":"COAPT-like profile predicts long-term outcomes in patients with secondary mitral regurgitation undergoing MitraClip implantation","volume":"14","author":"Adamo","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0020","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jcin.2022.02.018","article-title":"Transmitral gradients following transcatheter edge-to-edge repair: are mean gradients meaningful?","volume":"15","author":"Hahn","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0021","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcmg.2018.11.006","article-title":"Proportionate and disproportionate functional mitral regurgitation: a new conceptual framework that reconciles the results of the MITRA-FR and COAPT trials","volume":"12","author":"Grayburn","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0022","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jcin.2021.12.007","article-title":"Long-term outcomes of patients with elevated mitral valve pressure gradient after mitral valve edge-to-edge repair","volume":"15","author":"Koell","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0023","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/ejhf.2159","article-title":"Italian Society of Interventional Cardiology (GIse) registry of transcatheter treatment of mitral valve regurgitation (GIOTTO): impact of valve disease aetiology and residual mitral regurgitation after MitraClip implantation","volume":"23","author":"Bedogni","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2022.07.036_bib0024","doi-asserted-by":"crossref","unstructured":"F De Felice, L Paolucci, C Musto, A Cifarelli A, C Grasso, C Tamburino, M Adamo, P Denti, A Giordano, AL Bartorelli, M Montorfano, R Citro, A Mongiardo, I Monteforte, D Maffeo, C Giannini, G Crimi, G Tarantini, AP Rubbio, F Bedogni. Clinical outcomes and predictors in patients with previous cardiac surgery undergoing mitral valve transcatheter edge-to-edge repair [published online May 29, 2022]. Catheter Cardiovasc Interv. https:\/\/doi.org\/10.1002\/ccd.30245.","DOI":"10.1002\/ccd.30245"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291492200858X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291492200858X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:43:30Z","timestamp":1757573010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291492200858X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":24,"alternative-id":["S000291492200858X"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2022.07.036","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Outcomes in Patients With High Transmitral Gradient After Mitral Valve Transcatheter Edge-to-Edge Repair for Mitral Regurgitation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2022.07.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}