{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:28:48Z","timestamp":1772231328524,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016619","name":"MyoKardia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.amjcard.2022.12.030","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T05:06:10Z","timestamp":1674795970000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Clinical Outcomes, Resource Utilization, and Treatment Over the Disease Course of Symptomatic Obstructive Hypertrophic Cardiomyopathy in the United States"],"prefix":"10.1016","volume":"192","author":[{"given":"Nihar R.","family":"Desai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan B.","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jipan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer T.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali T.","family":"Owens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srihari S.","family":"Naidu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2022.12.030_bib0001","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0002","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1016\/j.jacc.2020.08.045","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"76","author":"Ommen","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0003","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA study. Coronary Artery Risk Development in (Young) Adults","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0004","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.amjcard.2016.02.044","article-title":"Occurrence of clinically diagnosed hypertrophic cardiomyopathy in the United States","volume":"117","author":"Maron","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0005","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jacc.2015.01.019","article-title":"New perspectives on the prevalence of hypertrophic cardiomyopathy","volume":"65","author":"Semsarian","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0006","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1056\/NEJMra1710575","article-title":"Clinical course and management of hypertrophic cardiomyopathy","volume":"379","author":"Maron","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0007","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/ejhf.541","article-title":"Pharmacological treatment of hypertrophic cardiomyopathy: current practice and novel perspectives","volume":"18","author":"Ammirati","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0008","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007161","article-title":"Impact of demographic features, lifestyle, and comorbidities on the clinical expression of hypertrophic cardiomyopathy","volume":"6","author":"Finocchiaro","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0009","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jchf.2018.02.010","article-title":"Hypertrophic cardiomyopathy: clinical update","volume":"6","author":"Geske","year":"2018","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s41687-020-00269-8","article-title":"Patient experiences with hypertrophic cardiomyopathy: a conceptual model of symptoms and impacts on quality of life","volume":"4","author":"Zaiser","year":"2020","journal-title":"J Patient Rep Outcomes"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0011","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3390\/jcm10050951","article-title":"Emerging medical treatment for hypertrophic cardiomyopathy","volume":"10","author":"Argir\u00f2","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0012","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(20)31793-1","article-title":"Mavacamten: treatment aspirations in hypertrophic cardiomyopathy","volume":"396","author":"Papadakis","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0013","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCULATIONAHA.117.033200","article-title":"Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the Sarcomeric Human cardiomyopathy Registry (SHaRe)","volume":"138","author":"Ho","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0014","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1161\/CIRCULATIONAHA.112.136085","article-title":"Risk stratification and outcome of patients with hypertrophic cardiomyopathy >=60 years of age","volume":"127","author":"Maron","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191214","article-title":"Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records","volume":"13","author":"Pujades-Rodriguez","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0016","unstructured":"IBM Watson health. IBM MarketScan research databases for life sciences researchers [white paper]. Available at: https:\/\/www.ibm.com\/downloads\/cas\/0NKLE57Y. Accessed on July 19, 2022."},{"key":"10.1016\/j.amjcard.2022.12.030_bib0017","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0018","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0019","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/0103-5150.028.002.AR02","article-title":"Disability after stroke: a systematic review","volume":"28","author":"Carmo","year":"2015","journal-title":"Fisioter Mov"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0020","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1161\/STROKEAHA.114.005648","article-title":"Long-term mortality after first-ever and recurrent stroke in young adults","volume":"45","author":"Aarnio","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0021","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/jama.2013.842","article-title":"Long-term mortality after stroke among adults aged 18 to 50 years","volume":"309","author":"Rutten-Jacobs","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0022","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006657","article-title":"Clinical outcomes in patients with nonobstructive, labile, and obstructive hypertrophic cardiomyopathy","volume":"7","author":"Lu","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0023","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1001\/jama.281.7.650","article-title":"Clinical course of hypertrophic cardiomyopathy in a regional United States cohort","volume":"281","author":"Maron","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2022.12.030_bib0024","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.amjcard.2006.07.029","article-title":"Determinants for clinical diagnosis of hypertrophic cardiomyopathy","volume":"98","author":"Adabag","year":"2006","journal-title":"Am J Cardiol"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914922013145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914922013145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:44:48Z","timestamp":1757573088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914922013145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":24,"alternative-id":["S0002914922013145"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2022.12.030","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Outcomes, Resource Utilization, and Treatment Over the Disease Course of Symptomatic Obstructive Hypertrophic Cardiomyopathy in the United States","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2022.12.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Myokardia Inc., a wholly owned subsidiary of Bristol Myers Squibb and The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}