{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:27:40Z","timestamp":1793834860812,"version":"4.6.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:00:00Z","timestamp":1685750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007753","name":"It\u00e4-Suomen Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.amjcard.2023.05.065","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T19:37:25Z","timestamp":1687376245000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Cardiorespiratory Fitness and Risk of Aortic Stenosis (from a Prospective Cohort Analysis)"],"prefix":"10.1016","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3738-1586","authenticated-orcid":false,"given":"Jari Antero","family":"Laukkanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Kurl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setor Kwadzo","family":"Kunutsor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2023.05.065_bib0001","series-title":"Percutaneous Treatment of Left Side Cardiac Valves: A Practical Guide for the Interventional Cardiologist","first-page":"245","article-title":"Aortic stenosis: epidemiology and pathogenesis","author":"Gulino","year":"2018"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0002","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/heartjnl-2012-302265","article-title":"The evolving epidemiology of valvular aortic stenosis. the Troms\u00f8 study","volume":"99","author":"Eveborn","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0003","unstructured":"Pujari SH, Agasthi P. Aortic stenosis. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557628\/. Accessed on February 15, 2023."},{"key":"10.1016\/j.amjcard.2023.05.065_bib0004","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study","volume":"62","author":"Osnabrugge","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0005","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1093\/eurheartj\/ehp287","article-title":"Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk factors: results of the longitudinal population-based KORA\/MONICA survey","volume":"30","author":"Stritzke","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0006","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0002-9149(01)01821-5","article-title":"Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons","volume":"88","author":"Aronow","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0007","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10654-020-00714-4","article-title":"Physical activity and risk of atrial fibrillation in the general population: meta-analysis of 23 cohort studies involving about 2 million participants","volume":"36","author":"Kunutsor","year":"2021","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0008","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/01.CIR.0000048890.59383.8D","article-title":"Cardiology patient pages. Exercise and cardiovascular health","volume":"107","author":"Myers","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0009","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.3390\/nu11122849","article-title":"Lifestyle interventions with a focus on nutritional strategies to increase cardiorespiratory fitness in chronic obstructive pulmonary disease, heart failure, obesity, sarcopenia, and frailty","volume":"11","author":"Billingsley","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0010","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1161\/CIR.0000000000000461","article-title":"Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association","volume":"134","author":"Ross","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0011","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.mayocp.2022.02.029","article-title":"Objectively assessed cardiorespiratory fitness and all-cause mortality risk: an updated meta-analysis of 37 cohort studies involving 2,258,029 participants","volume":"97","author":"Laukkanen","year":"2022","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0012","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.mayocp.2019.12.030","article-title":"Prognostic relevance of cardiorespiratory fitness as assessed by submaximal exercise testing for all-cause mortality: a UK Biobank prospective study","volume":"95","author":"Laukkanen","year":"2020","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0013","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/heartjnl-2015-309217","article-title":"Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men","volume":"103","author":"Hagn\u00e4s","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0014","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/ejhf.37","article-title":"Cardiorespiratory fitness and risk of heart failure: a population-based follow-up study","volume":"16","author":"Khan","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0015","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.pcad.2018.03.005","article-title":"Combined effect of sauna bathing and cardiorespiratory fitness on the risk of sudden cardiac deaths in Caucasian men: a long-term prospective cohort study","volume":"60","author":"Laukkanen","year":"2018","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0016","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/01.CIR.86.3.803","article-title":"High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men","volume":"86","author":"Salonen","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0017","first-page":"1","article-title":"Egg and cholesterol intake, apolipoprotein E4 phenotype and risk of venous thromboembolism: findings from a prospective cohort study","volume":"129","author":"Kunutsor","year":"2022","journal-title":"Br J Nutr"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0018","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.mayocp.2018.11.027","article-title":"Cardiorespiratory fitness and the risk of serious ventricular arrhythmias: a prospective cohort study","volume":"94","author":"Laukkanen","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0019","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pcad.2021.09.001","article-title":"Cardiorespiratory optimal point during exercise testing and sudden cardiac death: a prospective cohort study","volume":"68","author":"Laukkanen","year":"2021","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/HCR.0000000000000674","article-title":"Cardiorespiratory fitness, inflammation, and risk of chronic obstructive pulmonary disease in middle-aged men: a COHORT STUDY","volume":"42","author":"Kunutsor","year":"2022","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0021","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/HCR.0000000000000720","article-title":"Percentage of age-predicted cardiorespiratory fitness may be a stronger risk indicator for incident type 2 diabetes than absolute levels of cardiorespiratory fitness","volume":"43","author":"Kunutsor","year":"2023","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0022","series-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau","year":"2000"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0023","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/sim.4780080905","article-title":"Correction of logistic regression relative risk estimates and confidence intervals for systematic within-person measurement error","volume":"8","author":"Rosner","year":"1989","journal-title":"Stat Med"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0024","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/nep.12285","article-title":"Physiological benefits of exercise in pre-dialysis chronic kidney disease","volume":"19","author":"Gould","year":"2014","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/ATVBAHA.107.156752","article-title":"Calcific aortic stenosis: lessons learned from experimental and clinical studies","volume":"29","author":"Rajamannan","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0026","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1001\/jamacardio.2018.4647","article-title":"Extreme physical activity and coronary artery calcification-running heavily and safely with \u201chearts of stone\u201d","volume":"4","author":"Lavie","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0027","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCULATIONAHA.116.026964","article-title":"Prevalence of subclinical coronary artery disease in masters endurance athletes with a low atherosclerotic risk profile","volume":"136","author":"Merghani","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0028","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/jamacardio.2018.4628","article-title":"Association of all-cause and cardiovascular mortality with high levels of physical activity and concurrent coronary artery calcification","volume":"4","author":"DeFina","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0029","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jacc.2022.05.030","article-title":"Fit is it for longevity across populations","volume":"80","author":"Lavie","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2023.05.065_bib0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pcad.2020.11.003","article-title":"The impact of moving more, physical activity, and cardiorespiratory fitness: why we should strive to measure and improve fitness","volume":"64","author":"Myers","year":"2021","journal-title":"Prog Cardiovasc Dis"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291492300348X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291492300348X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:07:47Z","timestamp":1762078067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291492300348X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":30,"alternative-id":["S000291492300348X"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2023.05.065","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiorespiratory Fitness and Risk of Aortic Stenosis (from a Prospective Cohort Analysis)","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2023.05.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}