{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:47:53Z","timestamp":1776491273607,"version":"3.51.2"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFSC0553"],"award-info":[{"award-number":["2024NSFSC0553"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171182"],"award-info":[{"award-number":["32171182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019014","name":"Chengdu Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["2024-YF05-01820-SN"],"award-info":[{"award-number":["2024-YF05-01820-SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017520","name":"Chengdu Medical College","doi-asserted-by":"publisher","award":["24LHLX1-03"],"award-info":[{"award-number":["24LHLX1-03"]}],"id":[{"id":"10.13039\/100017520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.amjcard.2025.09.012","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T07:16:23Z","timestamp":1758698183000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The Role of Lipoprotein(a) in Cardiovascular Risk Stratification: Integrating Low-density Lipoprotein Cholesterol and Polygenic Risk Scores"],"prefix":"10.1016","volume":"259","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5580-5605","authenticated-orcid":false,"given":"Xiaoping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.amjcard.2025.09.012_bib0001","first-page":"346","article-title":"Lipoproteina(a) is a feature of the presence, diffuseness, and severity of coronary artery disease in Saudi population","volume":"30","author":"Habib","year":"2009","journal-title":"Saudi Med J"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0002","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0140-6736(24)01308-4","article-title":"Lipoprotein(a) and cardiovascular disease","volume":"404","author":"Nordestgaard","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0003","doi-asserted-by":"crossref","DOI":"10.1001\/jamacardio.2022.0987","article-title":"Lipoprotein(a) and its significance in cardiovascular disease","volume":"7","author":"Duarte Lau","year":"2022","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0004","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jacc.2012.04.038","article-title":"Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease","volume":"60","author":"Tsimikas","year":"2012","journal-title":"J Am College Cardiol"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0005","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/eurheartj\/ehz962","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"41","author":"Bor\u00e9n","year":"2020","journal-title":"Eur Heart J"},{"issue":"22","key":"10.1016\/j.amjcard.2025.09.012_bib0006","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1001\/jama.2009.801","article-title":"Genetically elevated lipoprotein(a) and increased risk of myocardial infarction","volume":"301","author":"Kamstrup","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0007","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/eurheartj\/ehz849","article-title":"Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385\u2009292 UK biobank participants","volume":"41","author":"Fan","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0008","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehaa1031","article-title":"Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank","volume":"42","author":"Wang","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0009","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.jacc.2022.02.018","article-title":"Elevated lipoprotein(a) and risk of atrial fibrillation","volume":"79","author":"Mohammadi-Shemirani","year":"2022","journal-title":"J Am College Cardiol"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0010","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1016\/j.jacl.2024.03.001","article-title":"A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice","volume":"18","author":"Koschinsky","year":"2024","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0011","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/pin.13202","article-title":"Atherosclerosis: known and unknown","volume":"72","author":"Fan","year":"2022","journal-title":"Pathol Int"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0012","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0013","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Eng J Med"},{"issue":"4","key":"10.1016\/j.amjcard.2025.09.012_bib0014","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/jama.2009.1063","article-title":"Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality","volume":"302","author":"Erqou","year":"2009","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.amjcard.2025.09.012_bib0015","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/clinchem\/hvaa247","article-title":"Lipoprotein(a) and cardiovascular disease","volume":"67","author":"Kamstrup","year":"2021","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0016","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1699-0463.1963.tb01808.x","article-title":"A new serum type system in man\u2014the lp system","volume":"59","author":"Berg","year":"1963","journal-title":"Acta Pathol Microbiol Scand"},{"issue":"11","key":"10.1016\/j.amjcard.2025.09.012_bib0017","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1093\/clinchem\/44.11.2301","article-title":"Lipoprotein(a) as a risk factor for ischemic heart disease: metaanalysis of prospective studies","volume":"44","author":"Craig","year":"1998","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0018","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/01.CIR.102.10.1082","article-title":"Lipoprotein(a) and coronary heart disease","volume":"102","author":"Danesh","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0019","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(18)31652-0","article-title":"Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials","volume":"392","author":"Willeit","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0020","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1161\/CIRCULATIONAHA.107.715698","article-title":"Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population","volume":"117","author":"Kamstrup","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2019.10.044","article-title":"Interaction of lipoprotein(a) with low-density lipoprotein cholesterol on first incident acute myocardial infarction","volume":"501","author":"Hu","year":"2020","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0022","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.atherosclerosis.2015.08.021","article-title":"Lipoprotein as a risk factor for ischemic stroke: a meta-analysis","volume":"242","author":"Nave","year":"2015","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.amjcard.2025.09.012_bib0023","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-95141-0","article-title":"Lipoprotein level as a risk factor for stroke and its subtype: a systematic review and met15660a-analysis","volume":"11","author":"Kumar","year":"2021","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.amjcard.2025.09.012_bib0024","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16501","article-title":"Impact of elevated lipoprotein(a) levels on the functional outcomes of ischemic stroke patients: a systematic review and meta-analysis","volume":"31","author":"Liu","year":"2024","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0025","doi-asserted-by":"crossref","unstructured":"Mahadevan A, Annam S, Tullimalli IR, Raj R, Kaur P, Gondi Y, Lakkimsetti M, Rajbhandari P, Valluri JP, Anil Peethambar G and Desai R. Abstract WP243: elevated lipoprotein(a) as a predictor for recurrent ischemic cerebrovascular events: a meta-analysis of cohort studies. 2024;55:AWP243.","DOI":"10.1161\/str.55.suppl_1.WP243"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0026","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1161\/STROKEAHA.119.026872","article-title":"Causal effect of lp(a) [Lipoprotein(a)] level on ischemic stroke and Alzheimer Disease","volume":"50","author":"Pan","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0027","first-page":"15","article-title":"Lipoprotein(a) and stroke: a two-sample mendelian randomization study","author":"Huang","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0028","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.31236","article-title":"The association between lipoprotein(a) levels and ischemic stroke in children: a case\u2013control study","volume":"71","author":"de Boer","year":"2024","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0029","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007372","article-title":"Associations of lipoprotein(a) levels with incident atrial fibrillation and ischemic stroke: the ARIC (Atherosclerosis Risk in Communities) study","volume":"6","author":"Aronis","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.amjcard.2025.09.012_bib0030","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0021-9150(99)00388-3","article-title":"Lipoprotein and the risk of ischemic stroke in young women","volume":"150","author":"Wityk","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0031","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1161\/01.STR.0000222666.21482.b6","article-title":"Lipoprotein(a) and incident ischemic stroke","volume":"37","author":"Ohira","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0032","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.amjcard.2025.09.012_bib0033","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/cvr\/cvab017","article-title":"Relationship between lipoproteins, thrombosis, and atrial fibrillation","volume":"118","author":"Ding","year":"2022","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0034","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.numecd.2021.02.011","article-title":"Causal effects of plasma lipids on the risk of atrial fibrillation: a multivariable mendelian randomization study","volume":"31","author":"Jiang","year":"2021","journal-title":"Nutr Metabol Cardiovasc Dis"},{"issue":"1","key":"10.1016\/j.amjcard.2025.09.012_bib0035","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12944-022-01682-2","article-title":"Association between lipoprotein(a) and thromboembolism in patients with non-valvular atrial fibrillation: a cross-sectional study","volume":"21","author":"Song","year":"2022","journal-title":"Lipids Health Dis"},{"issue":"3","key":"10.1016\/j.amjcard.2025.09.012_bib0036","doi-asserted-by":"crossref","first-page":"267","DOI":"10.12997\/jla.2023.12.3.267","article-title":"Elevated lipoprotein(a) levels and atrial fibrillation: a systematic review","volume":"12","author":"Masson","year":"2023","journal-title":"J Lipid Atheroscler"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0037","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/clc.24086","article-title":"The association between lipoprotein(a) and atrial fibrillation: a systemic review and meta-analysis","volume":"46","author":"Yang","year":"2023","journal-title":"Clin Cardiol"},{"issue":"12","key":"10.1016\/j.amjcard.2025.09.012_bib0038","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/eurjpc\/zwad171","article-title":"Causal relationships between the gut microbiome, blood lipids, and heart failure: a mendelian randomization analysis","volume":"30","author":"Dai","year":"2023","journal-title":"Eur J Prev Cardiol"},{"issue":"8","key":"10.1016\/j.amjcard.2025.09.012_bib0039","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1001\/jamacardio.2018.1919","article-title":"A Swedish nationwide adoption study of the heritability of heart failure","volume":"3","author":"Lindgren","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"9","key":"10.1016\/j.amjcard.2025.09.012_bib0040","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3390\/genes15091126","article-title":"A multivariable mendelian randomization study of systolic and diastolic blood pressure, lipid profile, and heart failure subtypes","volume":"15","author":"Liu","year":"2024","journal-title":"Genes"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0041","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jchf.2015.08.006","article-title":"Elevated lipoprotein(a) levels, LPA risk genotypes, and increased risk of heart failure in the general population","volume":"4","author":"Kamstrup","year":"2016","journal-title":"JACC Heart Fail"},{"issue":"5","key":"10.1016\/j.amjcard.2025.09.012_bib0042","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11883-009-0052-4","article-title":"Low-density lipoprotein in the setting of congestive heart failure: is lower really better?","volume":"11","author":"Horwich","year":"2009","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.amjcard.2025.09.012_bib0043","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/chf.12006","article-title":"Low-density lipoprotein levels in patients with acute heart failure","volume":"19","author":"Kahn","year":"2012","journal-title":"Congest Heart Fail"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914925005624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914925005624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:43:13Z","timestamp":1773261793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914925005624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":43,"alternative-id":["S0002914925005624"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2025.09.012","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Lipoprotein(a) in Cardiovascular Risk Stratification: Integrating Low-density Lipoprotein Cholesterol and Polygenic Risk Scores","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2025.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}