{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:59:05Z","timestamp":1791669545866,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi Sankyo Chemical Pharma Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019341","name":"Medtronic Japan Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009015","name":"Abbott Japan Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.amjcard.2026.08.007","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:48:55Z","timestamp":1786722535000},"page":"85-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Early Transcatheter Edge-to-Edge Repair Is Associated With Improved Mid-term Outcomes in Degenerative Mitral Regurgitation"],"prefix":"10.1016","volume":"277","author":[{"given":"Tetsuro","family":"Shimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itta","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Kagase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsunamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Asami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Enta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hachinohe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Izumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Amaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Naganuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Bota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjcard.2026.08.007_bib0001","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005971","article-title":"Pathophysiology of degenerative mitral regurgitation: new 3-dimensional imaging insights","volume":"11","author":"Antoine","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0002","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.athoracsur.2019.07.014","article-title":"Degenerative mitral valve repair restores life expectancy","volume":"109","author":"Watt","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0003","first-page":"e72","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0004","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0005","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/eurheartj\/ehm001","article-title":"What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery?","volume":"28","author":"Mirabel","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0006","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"Feldman","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0007","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1001\/jama.2023.7089","article-title":"Transcatheter mitral valve repair for degenerative mitral regurgitation","volume":"329","author":"Makkar","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0008","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1038\/s41440-025-02249-1","article-title":"Prognostic impact of the timing of antihypertensive medication initiation for hypertension detected at health screening on primary prevention of adverse cardiovascular events: age-stratified real-world data analysis","volume":"48","author":"Ito","year":"2025","journal-title":"Hypertens Res"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0009","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.122.010426","article-title":"Long-term outcomes of early coronary artery disease testing after new-onset heart failure","volume":"16","author":"Zheng","year":"2023","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1912846","article-title":"Early surgery or conservative care for asymptomatic aortic stenosis","volume":"382","author":"Kang","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0011","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJMoa2405880","article-title":"Transcatheter aortic-valve replacement for asymptomatic severe aortic stenosis","volume":"392","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0012","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa041451","article-title":"Quantitative determinants of the outcome of asymptomatic mitral regurgitation","volume":"352","author":"Enriquez-Sarano","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0013","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jtcvs.2008.10.026","article-title":"Recovery of left ventricular function after surgical correction of mitral regurgitation caused by leaflet prolapse","volume":"137","author":"Suri","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0014","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jama.2013.8643","article-title":"Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets","volume":"310","author":"Suri","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0015","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.jacc.2014.02.577","article-title":"Early surgery versus conventional treatment for asymptomatic severe mitral regurgitation: a propensity analysis","volume":"63","author":"Kang","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0016","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.123.013794","article-title":"Cardiac damage in degenerative mitral regurgitation treated with transcatheter mitral edge-to-edge repair","volume":"17","author":"Sugiura","year":"2024","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0017","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030747","article-title":"One-year outcomes and their relationship to residual mitral regurgitation after transcatheter edge-to-edge repair with MitraClip device: insights from the OCEAN-Mitral registry","volume":"12","author":"Kubo","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0018","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jacasi.2023.06.008","article-title":"Short-term outcomes following transcatheter edge-to-edge repair: insights from the OCEAN-Mitral registry","volume":"3","author":"Saji","year":"2023","journal-title":"JACC Asia"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0019","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0020","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.amjcard.2007.06.066","article-title":"Quantitative assessment of severity of mitral regurgitation by serial echocardiography in a multicenter clinical trial of percutaneous mitral valve repair","volume":"100","author":"Foster","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0021","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0022","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0023","first-page":"220","article-title":"Early surgical intervention or watchful waiting for the management of asymptomatic mitral regurgitation: a systematic review and meta-analysis","volume":"4","author":"Goldstone","year":"2015","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0024","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009195","article-title":"Patients refusing transcatheter aortic valve replacement even once have poorer clinical outcomes","volume":"7","author":"Shimura","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0025","first-page":"401","article-title":"Low body mass index and risk of mortality after mitral transcatheter edge-to-edge repair procedure: the \u201cobesity paradox\u201d","volume":"104","author":"Carter-Storch","year":"2024","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0026","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.125.041961","article-title":"Clinical impact of early changes in serum albumin on patient prognosis after mitral-transcatheter edge-to-edge repair","volume":"14","author":"Shibata","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0027","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/ehf2.13699","article-title":"Chronic kidney disease and risk of atrial fibrillation and heart failure in general population-based cohorts: the BiomarCaRE project","volume":"9","author":"Rehm","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0028","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1253\/circrep.CR-21-0027","article-title":"Impact of atrial fibrillation on the prognosis of acute decompensated heart failure with and without mitral regurgitation","volume":"3","author":"Hirai","year":"2021","journal-title":"Circ Rep"},{"key":"10.1016\/j.amjcard.2026.08.007_bib0029","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jchf.2019.10.005","article-title":"Frailty is intertwined with heart failure: mechanisms, prevalence, prognosis, assessment, and management","volume":"7","author":"Pandey","year":"2019","journal-title":"JACC Heart Fail"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914926005199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914926005199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:16:38Z","timestamp":1790424998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914926005199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S0002914926005199"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2026.08.007","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Transcatheter Edge-to-Edge Repair Is Associated With Improved Mid-term Outcomes in Degenerative Mitral Regurgitation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2026.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}