{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:01:35Z","timestamp":1790892095903,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajconline.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Cardiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.amjcard.2026.09.023","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:10Z","timestamp":1790697910000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decreases in Left Atrial Strain with Mavacamten Therapy and Associations with Atrial Fibrillation"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-7783","authenticated-orcid":false,"given":"Myra","family":"Lewontin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqub","family":"Betz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.","family":"Bilchick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"MacNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"McClean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Amos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Parrish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ayers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10253","key":"10.1016\/j.amjcard.2026.09.023_bib0001","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(20)31792-X","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"396","author":"Olivotto","year":"2020","journal-title":"The Lancet"},{"issue":"2","key":"10.1016\/j.amjcard.2026.09.023_bib0002","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jacc.2022.04.048","article-title":"Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy","volume":"80","author":"Desai","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.amjcard.2026.09.023_bib0003","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.jcmg.2023.06.008","article-title":"Early Observations on Effects of Mavacamten on Left Atrial Function in Obstructive Hypertrophic Cardiomyopathy Patients","volume":"16","author":"Wessly","year":"2023","journal-title":"J Am Coll Cardiol Img"},{"issue":"4","key":"10.1016\/j.amjcard.2026.09.023_bib0004","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005467","article-title":"Influence of Left Atrial Function on Exercise Capacity and Left Ventricular Function in Patients With Heart Failure and Preserved Ejection Fraction","volume":"10","author":"von Roeder","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.amjcard.2026.09.023_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1168514","article-title":"Evaluation of the relationship between left atrial strain and exercise tolerance in patients with hypertrophic cardiomyopathy by treadmill stress echocardiography","volume":"10","author":"Su","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"10.1016\/j.amjcard.2026.09.023_bib0006","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/CIRCULATIONAHA.120.052359","article-title":"Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM Cardiac Magnetic Resonance Substudy Analysis","volume":"143","author":"Saberi","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2026.09.023_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.cardfail.2023.11.009","article-title":"Left Atrial Functional Assessment in Hypertrophic Cardiomyopathy Patients Receiving Mavacamten","volume":"30","author":"Muuse","year":"2024","journal-title":"J Card Fail"},{"issue":"25","key":"10.1016\/j.amjcard.2026.09.023_bib0008","first-page":"07460","article-title":"Echocardiographic Changes With Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy: Exploratory Insights From the ODYSSEY-HCM Trial","volume":"S0735-1097","author":"Desai","year":"2025","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.amjcard.2026.09.023_bib0009","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jcmg.2024.08.005","article-title":"Mavacamten-Associated Temporal Changes in Left Atrial Function in Obstructive HCM","volume":"18","author":"Desai","year":"2025","journal-title":"JACC Cardiovasc Imaging"},{"issue":"3","key":"10.1016\/j.amjcard.2026.09.023_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2021.11.2179","article-title":"Mavacamten depresses human atrial contractility in the same EC50% range as human ventricle","volume":"121","author":"Ferrantini","year":"2022","journal-title":"Biophys J"},{"issue":"8","key":"10.1016\/j.amjcard.2026.09.023_bib0011","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.124.017160","article-title":"Left Atrial Strain During Exercise: A Window to Atrioventricular Coupling in Heart Failure","volume":"17","author":"Morello","year":"2024","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.amjcard.2026.09.023_bib0012","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/ehjci\/jeab202","article-title":"Left atrial strain predicts incident atrial fibrillation in the general population: the Copenhagen City Heart Study","volume":"23","author":"Hauser","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"21","key":"10.1016\/j.amjcard.2026.09.023_bib0013","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026875","article-title":"Left Atrial Strain and the Risk of Atrial Arrhythmias From Extended Ambulatory Cardiac Monitoring: MESA","volume":"11","author":"Huber","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"25","key":"10.1016\/j.amjcard.2026.09.023_bib0014","article-title":"2020 AHA\/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy","volume":"142","author":"Ommen","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.amjcard.2026.09.023_bib0015","unstructured":"Camzyos. Prescribing information."},{"issue":"1","key":"10.1016\/j.amjcard.2026.09.023_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2018.06.004","article-title":"Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography","volume":"32","author":"Mitchell","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"issue":"6","key":"10.1016\/j.amjcard.2026.09.023_bib0017","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.echo.2022.03.012","volume":"35","author":"Nagueh","year":"2022","journal-title":"J Am Soc Echocardiogr"},{"issue":"6","key":"10.1016\/j.amjcard.2026.09.023_bib0018","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjci\/jey042","article-title":"Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"19","author":"Badano","year":"2018","journal-title":"Eur Heart J - Cardiovasc Imaging"},{"issue":"4","key":"10.1016\/j.amjcard.2026.09.023_bib0019","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jcmg.2022.11.002","article-title":"Prognostic Implications of Left Atrial Stiffness Index in Heart Failure Patients With Preserved Ejection Fraction","volume":"16","author":"Kim","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.amjcard.2026.09.023_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0245934","article-title":"Hemodynamic determinants of left atrial strain in patients with hypertrophic cardiomyopathy: A combined echocardiography and CMR study","volume":"16","author":"Tayal","year":"2021","journal-title":"PLOS ONE"},{"issue":"7","key":"10.1016\/j.amjcard.2026.09.023_bib0021","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.echo.2009.04.026","article-title":"Correlation between Left Ventricular End-diastolic Pressure and Peak Left Atrial Wall Strain during Left Ventricular Systole","volume":"22","author":"Wakami","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"issue":"Suppl_1","key":"10.1016\/j.amjcard.2026.09.023_bib0022","doi-asserted-by":"crossref","DOI":"10.1161\/circ.148.suppl_1.15822","article-title":"Abstract 15822: Cardiac Effects of EDG-7500, a Novel Cardiac Sarcomere Regulator: In vitro and in vivo Evidence for Slowing Isovolumic Contraction and Improved Ventricular Compliance","volume":"148","author":"Del Rio CL","year":"2023","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.amjcard.2026.09.023_bib0023","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.121.013836","article-title":"Hemodynamic Determinants of Left Atrial Strain in Symptomatic Patients With Significant Primary Mitral Regurgitation","volume":"15","author":"Pournazari","year":"2022","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.amjcard.2026.09.023_bib0024","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/ehjci\/jeaa415","article-title":"Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure","volume":"23","author":"Inoue","year":"2021","journal-title":"Eur Heart J - Cardiovasc Imaging"},{"issue":"5","key":"10.1016\/j.amjcard.2026.09.023_bib0025","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jcmg.2022.10.011","article-title":"Left Atrial Strain for Assessment of Left Ventricular Diastolic Function: Focus on Populations With Normal LVEF","volume":"16","author":"Nagueh","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.amjcard.2026.09.023_bib0026","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/01.RES.62.6.1210","article-title":"Passive properties of canine left ventricle: diastolic stiffness and restoring forces","volume":"62","author":"Nikoli\u0107","year":"1988","journal-title":"Circ Res"},{"issue":"22","key":"10.1016\/j.amjcard.2026.09.023_bib0027","doi-asserted-by":"crossref","first-page":"12688","DOI":"10.1073\/pnas.2133733100","article-title":"Damped elastic recoil of the titin spring in myofibrils of human myocardium","volume":"100","author":"Opitz","year":"2003","journal-title":"Proc Natl Acad Sci"},{"issue":"10","key":"10.1016\/j.amjcard.2026.09.023_bib0028","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.hrthm.2024.04.055","article-title":"Incidence of newly recognized atrial fibrillation in patients with obstructive hypertrophic cardiomyopathy treated with Mavacamten","volume":"21","author":"Castrichini","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.amjcard.2026.09.023_bib0029","doi-asserted-by":"crossref","unstructured":"Boyle TA, Reza N, Hyman M, et al. Atrial Fibrillation in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy. JACC Clin Electrophysiol. 0(0). doi:10.1016\/j.jacep.2024.10.014","DOI":"10.1016\/j.jacep.2024.10.014"},{"issue":"Suppl_1","key":"10.1016\/j.amjcard.2026.09.023_bib0030","article-title":"Abstract 19176: Atrial Fibrillation Prevalence With Mavacamten for Obstructive Hypertrophic Cardiomyopathy","volume":"148","author":"jaikumar likhitesh","year":"2023","journal-title":"Circulation"}],"container-title":["The American Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914926006028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002914926006028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:36:00Z","timestamp":1790890560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002914926006028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"alternative-id":["S0002914926006028"],"URL":"https:\/\/doi.org\/10.1016\/j.amjcard.2026.09.023","relation":{},"ISSN":["0002-9149"],"issn-type":[{"value":"0002-9149","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreases in Left Atrial Strain with Mavacamten Therapy and Associations with Atrial Fibrillation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjcard.2026.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}