{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:50:52Z","timestamp":1790175052086,"version":"4.1.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.amjmed.2003.09.045","type":"journal-article","created":{"date-parts":[[2004,4,2]],"date-time":"2004-04-02T05:15:22Z","timestamp":1080882922000},"page":"546-554","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":240,"title":["Pathophysiology, clinical consequences, and treatment of tumor lysis syndrome"],"prefix":"10.1016","volume":"116","author":[{"given":"Michael B","family":"Davidson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K","family":"Hix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen D","family":"Bhandarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2003.09.045_BIB1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archinte.1977.03630130065016","article-title":"Hyperuricemic acute renal failure in disseminated carcinoma","volume":"137","author":"Crittenden","year":"1977","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ajh.2830470212","article-title":"Acute spontaneous tumor lysis syndrome","volume":"47","author":"Jasek","year":"1994","journal-title":"Am J Hematol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1081\/JDI-120004100","article-title":"Acute renal failure from spontaneous acute tumor lysis syndrome","volume":"24","author":"Alkhuja","year":"2002","journal-title":"Ren Fail"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00000421-200010000-00012","article-title":"Acute spontaneous tumor lysis syndrome in adenocarcinoma of the lung","volume":"23","author":"Feld","year":"2000","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB5","first-page":"59","article-title":"Continuous veno-venous hemodiafiltration for the treatment of spontaneous tumor lysis syndrome complicated by acute renal failure and severe hyperuricemia","volume":"54","author":"Agha-Razii","year":"2000","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB6","first-page":"1700","article-title":"Akuter Harnleiterverschluss nach Bestrahlung chronischer Leuk\u00e4mien mit R\u00f6ntgenstrahlen","volume":"25","author":"Bedrna","year":"1929","journal-title":"Med Klin"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB7","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0002-9343(80)90286-7","article-title":"Acute tumor lysis syndrome","volume":"68","author":"Cohen","year":"1980","journal-title":"Am J Med"},{"issue":"suppl 5","key":"10.1016\/j.amjmed.2003.09.045_BIB8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0093-7754(01)90254-4","article-title":"Acute tumor lysis syndrome","volume":"28","author":"Altman","year":"2001","journal-title":"Semin Oncol"},{"issue":"suppl 10","key":"10.1016\/j.amjmed.2003.09.045_BIB9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0037-1963(01)90037-X","article-title":"Tumor lysis syndrome","volume":"38","author":"Jeha","year":"2001","journal-title":"Semin Hematol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB10","first-page":"322","article-title":"Metabolic emergencies in the cancer patient","volume":"27","author":"Flombaum","year":"2000","journal-title":"Semin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB11","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4065\/77.7.722","article-title":"Acute tumor lysis syndrome in a patient with mixed small cell and non-small cell tumor","volume":"77","author":"Sewani","year":"2002","journal-title":"Mayo Clinic Proc"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0002-9343(97)00153-8","article-title":"Tumor lysis syndrome in small cell carcinoma and other solid tumors","volume":"103","author":"Kalemkerian","year":"1997","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/00000421-199808000-00024","article-title":"Tumor lysis syndrome and acute renal failure after treatment of non-small-cell lung carcinoma with combination irinotecan and cisplatin","volume":"21","author":"Persons","year":"1998","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB14","first-page":"112","article-title":"Flare and tumor lysis syndrome with atypical features after letrozole therapy in advanced breast cancer. A case report","volume":"16","author":"Zigrossi","year":"2001","journal-title":"Ann Ital Med Int"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB15","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1023\/A:1008347226743","article-title":"Tumor lysis syndrome following hemi-body irradiation for metastatic breast cancer","volume":"11","author":"Rostom","year":"2000","journal-title":"Ann Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00000421-199502000-00015","article-title":"Spontaneous recurrent tumor lysis syndrome in breast cancer","volume":"18","author":"Sklarin","year":"1995","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB17","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/1097-0142(19870815)60:4<762::AID-CNCR2820600409>3.0.CO;2-P","article-title":"Related fatal acute tumor lysis syndrome with metastatic breast carcinoma","volume":"60","author":"Stark","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM198607243150417","article-title":"Tumor lysis syndrome after tamoxifen flare","volume":"315","author":"Cech","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB19","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00000421-199412000-00010","article-title":"Tumor lysis syndrome in nonhematologic malignancies","volume":"17","author":"Drakos","year":"1994","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mpo.2950230213","article-title":"Acute tumour lysis syndrome complicating treatment of stage IVS neuroblastoma in infants under six months old","volume":"23","author":"Hain","year":"1994","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB21","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/1097-0142(19840415)53:8<1783::AID-CNCR2820530829>3.0.CO;2-F","article-title":"Acute tumor lysis syndrome with metastatic medulloblastoma. A case report","volume":"53","author":"Tomlinson","year":"1984","journal-title":"Cancer"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00000421-199702000-00020","article-title":"Tumor lysis syndrome in invasive thymoma with peripheral blood T-cell lymphocytosis","volume":"20","author":"Yokoi","year":"1997","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/08880019309016549","article-title":"Tumor lysis syndrome complicating treatment of widespread metastatic abdominal rhabdomyosarcoma","volume":"10","author":"Khan","year":"1993","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB24","first-page":"415","article-title":"Fatal acute tumor lysis syndrome following treatment of vulvar carcinoma","volume":"19","author":"Khalil","year":"1998","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/gyno.1993.1283","article-title":"Acute tumor lysis syndrome with squamous cell carcinoma of the vulva","volume":"51","author":"Shamseddine","year":"1993","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB26","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1002\/1097-0142(19910415)67:8<2207::AID-CNCR2820670834>3.0.CO;2-R","article-title":"Tumor lysis syndrome in a patient with metastatic Merkel cell carcinoma","volume":"67","author":"Dirix","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB27","first-page":"554","article-title":"Spontaneous acute tumour lysis syndrome in patients with metastatic germ cell tumours. Report of two cases","volume":"9","author":"Pentheroudakis","year":"2001","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB28","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/1097-0142(19890801)64:3<738::AID-CNCR2820640328>3.0.CO;2-Z","article-title":"Tumor lysis syndrome in nonhematopoietic malignancies","volume":"64","author":"Barton","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB29","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/mpo.2950210712","article-title":"Tumor lysis syndrome after combination chemotherapy for ovarian cancer","volume":"21","author":"Bilgrami","year":"1993","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00000441-200203000-00007","article-title":"Tumor lysis syndrome after hydrocortisone treatment in metastatic melanoma","volume":"323","author":"Habib","year":"2002","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/ndt\/16.1.188","article-title":"Tumour lysis syndrome in a patient with metastatic melanoma treated with biochemotherapy","volume":"16","author":"Stoves","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000204328","article-title":"Incidence and treatment of tumour lysis syndrome in patients with acute leukaemia","volume":"91","author":"Razis","year":"1994","journal-title":"Acta Haematol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB33","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/pgmj.70.827.651","article-title":"Tumour lysis syndrome after treatment of chronic lymphocytic leukaemia with fludarabine","volume":"70","author":"Montalban","year":"1994","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB34","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/(SICI)1097-0142(19990301)85:5<1055::AID-CNCR7>3.0.CO;2-3","article-title":"Acute tumor lysis syndrome associated with concurrent biochemotherapy of metastatic melanoma","volume":"85","author":"Castro","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB35","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1023\/A:1006341717398","article-title":"Infusion reactions associated with the therapeutic use of monoclonal antibodies in the treatment of malignancy","volume":"18","author":"Dillman","year":"1999","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB36","first-page":"235","article-title":"Radiation induced acute tumor lysis syndrome in the bone marrow transplant setting","volume":"8","author":"Fleming","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB37","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0002-9343(84)90550-3","article-title":"Atypical tumor lysis syndrome in a patient with T-cell lymphoma treated with recombinant leukocyte interferon","volume":"77","author":"Fer","year":"1984","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/(SICI)1096-8652(199701)54:1<85::AID-AJH15>3.0.CO;2-9","article-title":"Tumor lysis syndrome in a case of chronic lymphocytic leukemia induced by high-dose corticosteroids","volume":"54","author":"Coutinho","year":"1997","journal-title":"Am J Hematol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB39","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00007611-199403000-00024","article-title":"Dexamethasone-induced tumor lysis syndrome in high-grade non-Hodgkin's lymphoma","volume":"87","author":"Malik","year":"1994","journal-title":"South Med J"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB40","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/1097-0142(19900301)65:5<1072::AID-CNCR2820650504>3.0.CO;2-A","article-title":"Increasing recognition of corticosteroid-induced tumor lysis syndrome in non-Hodgkin's lymphoma","volume":"65","author":"Sparano","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1001\/archinte.1978.03630280074023","article-title":"A rapid method for the diagnosis of acute uric acid nephropathy","volume":"138","author":"Kelton","year":"1978","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB42","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/oxfordjournals.annonc.a010682","article-title":"Tumour lysis syndrome, case report and review of the literature","volume":"7","author":"Lorigan","year":"1996","journal-title":"Ann Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB43","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0749-0704(18)30525-6","article-title":"Toxic nephropathies","volume":"3","author":"Sondheimer","year":"1987","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF00860751","article-title":"Tumor lysis syndrome","volume":"9","author":"Jones","year":"1995","journal-title":"Pediatr Nephrol"},{"issue":"suppl 5","key":"10.1016\/j.amjmed.2003.09.045_BIB45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0093-7754(01)90255-6","article-title":"Management of acute tumor lysis syndrome","volume":"28","author":"Sallan","year":"2001","journal-title":"Semin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB46","series-title":"Harrison's Principles of Internal Medicine","first-page":"271","article-title":"Fluid and electrolyte disturbances","author":"Singer","year":"2001"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB47","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJM196603032740902","article-title":"Use of allopurinol for prevention and control of hyperuricemia in patients with neoplastic disease","volume":"274","author":"DeConti","year":"1966","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0022-3476(82)80259-X","article-title":"Urate-oxidase prophylaxis of uric acid-induced renal damage in childhood leukemia","volume":"100","author":"Masera","year":"1982","journal-title":"J Pediatr"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB49","doi-asserted-by":"crossref","first-page":"114","DOI":"10.7326\/0003-4819-109-2-114","article-title":"Use of polyethylene glycol-modified uricase (PEG-uricase) to treat hyperuricemia in a patient with non-Hodgkin lymphoma","volume":"109","author":"Chua","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB50","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1038\/sj.leu.2400850","article-title":"Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies","volume":"11","author":"Pui","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB51","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1200\/JCO.2000.18.8.1758","article-title":"Allopurinol","volume":"18","author":"Smalley","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB52","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1200\/JCO.2001.19.3.697","article-title":"Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients with leukemia or lymphoma","volume":"19","author":"Pui","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB53","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1182\/blood.V97.10.2998","article-title":"A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis","volume":"97","author":"Goldman","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB54","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/BF02474201","article-title":"Solubility of uric acid and monosodium urate","volume":"10","author":"Wilcox","year":"1972","journal-title":"Med Biol Eng"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB55","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1172\/JCI108514","article-title":"A micropuncture study of the early phase of acute urate nephropathy","volume":"58","author":"Conger","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB56","first-page":"273","article-title":"Tumor lysis syndrome","volume":"13","author":"Arrambide","year":"1993","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB57","first-page":"47","article-title":"Transient acute renal failure due to tumor-lysis-induced severe phosphate load in a patient with Burkitt's lymphoma","volume":"22","author":"Monballyu","year":"1984","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB58","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1172\/JCI108700","article-title":"Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy","volume":"59","author":"Conger","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB59","first-page":"126","article-title":"Effects of xanthine oxidase inhibitor on thiopurine metabolism, hyperuricemia, and gout","volume":"76","author":"Rundles","year":"1963","journal-title":"Trans Assoc Am Phys"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB60","doi-asserted-by":"crossref","unstructured":"Feusner J, Farber MS. Role of intravenous allopurinol in the management of acute tumor lysis syndrome. Semin Oncol 2001(suppl 5):13\u201318","DOI":"10.1016\/S0093-7754(01)90256-8"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB61","unstructured":"Allopurinol [prescribing information]. Corona, California: Watson Laboratories; June 2002"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB62","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1056\/NEJM197008132830708","article-title":"Xanthine nephropathy in a patient with lymphosarcoma treated with allopurinol","volume":"283","author":"Band","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB63","first-page":"890","article-title":"Enzymatic uricolysis","volume":"17","author":"Brogard","year":"1972","journal-title":"Rev Eur Etud Clin Biol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB64","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0378-1119(91)90622-I","article-title":"Molecular evolution of the urate oxidase-encoding gene in hominoid primates","volume":"109","author":"Yeldandi","year":"1991","journal-title":"Gene"},{"issue":"suppl 10","key":"10.1016\/j.amjmed.2003.09.045_BIB65","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0037-1963(01)90038-1","article-title":"European experience in the treatment of hyperuricemia","volume":"38","author":"Patte","year":"2001","journal-title":"Semin Hematol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB66","first-page":"2171","article-title":"Urate-oxydase for gouty arthritis in cardiac transplant recipients","volume":"20","author":"Rozenberg","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB67","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0378-1119(92)90041-M","article-title":"High-level production of a peroxisomal enzyme","volume":"122","author":"Leplatois","year":"1992","journal-title":"Gene"},{"issue":"pt 1","key":"10.1016\/j.amjmed.2003.09.045_BIB68","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/BA20010083","article-title":"Modification of a reactive cysteine explains differences between rasburicase and Uricozyme, a natural Aspergillus flavus uricase","volume":"36","author":"Bayol","year":"2002","journal-title":"Biotechnol Appl Biochem"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB69","unstructured":"Elitek (rasburicase) [prescribing information]. New York, New York: Sanofi-Synthelabo Inc.; July 2002"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB70","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1517\/14656566.3.4.433","article-title":"Rasburicase","volume":"3","author":"Pui","year":"2002","journal-title":"Exp Opin Pharmacother"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB71","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1188\/02.CJON.12-16","article-title":"Rasburicase","volume":"6","author":"Brant","year":"2002","journal-title":"Clin J Oncol Nurs"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM196601062740101","article-title":"Inorganic phosphate treatment of hypercalcemia of diverse etiologies","volume":"274","author":"Goldsmith","year":"1966","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB73","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archinte.1974.00320150023002","article-title":"Hyperuricemic acute renal failure","volume":"133","author":"Kjellstrand","year":"1974","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB74","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000420198","article-title":"Clearance studies in patients with acute renal failure treated by continuous arteriovenous haemodialysis","volume":"93","author":"Davies","year":"1991","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB75","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1525-1594.1994.tb02228.x","article-title":"A comparison of molecular clearance rates during continuous hemofiltration and hemodialysis with a novel volumetric continuous renal replacement system","volume":"18","author":"Jeffrey","year":"1994","journal-title":"Artif Organs"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB76","first-page":"437","article-title":"Peritoneal clearances. Long term study","volume":"34","author":"Procaccini","year":"1988","journal-title":"ASAIO Trans"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB77","first-page":"286","article-title":"Diffusion kinetics of urea, creatinine and uric acid in blood during hemodialysis. Clinical implications","volume":"40","author":"Descombes","year":"1993","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB78","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/00000441-196304000-00005","article-title":"Peritoneal dialysis in leukemia and uric acid nephropathy","volume":"245","author":"Duke","year":"1963","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB79","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0272-6386(12)80384-2","article-title":"High dialysate flow rate continuous arteriovenous hemodialysis","volume":"23","author":"Pichette","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB80","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/08860229809045157","article-title":"Management of tumor lysis syndrome with standard continuous arteriovenous hemodialysis","volume":"20","author":"Schelling","year":"1998","journal-title":"Ren Fail"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB81","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00857665","article-title":"Continuous arteriovenous haemofiltration in the treatment of tumour lysis syndrome","volume":"4","author":"Heney","year":"1990","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB82","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF00866363","article-title":"Hyperphosphatemia in tumor lysis syndrome","volume":"8","author":"Sakarcan","year":"1994","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB83","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00043426-200102000-00016","article-title":"Tumor lysis syndrome in an infant with Langerhans cell histiocytosis successfully treated using continuous arteriovenous hemofiltration","volume":"23","author":"Jaing","year":"2001","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.amjmed.2003.09.045_BIB84","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF00860936","article-title":"Prevention of tumor lysis syndrome using continuous veno-venous hemofiltration","volume":"9","author":"Saccente","year":"1995","journal-title":"Pediatr Nephrol"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934303007253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934303007253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:28:51Z","timestamp":1757579331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934303007253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":84,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0002934303007253"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2003.09.045","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathophysiology, clinical consequences, and treatment of tumor lysis syndrome","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2003.09.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Excerpta Medica Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}