{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:11:46Z","timestamp":1792721506756,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.amjmed.2004.02.030","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T10:22:16Z","timestamp":1087899736000},"page":"39-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":381,"title":["The antineutrophil cytoplasmic antibody\u2013associated vasculitides"],"prefix":"10.1016","volume":"117","author":[{"given":"Philip","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2004.02.030_BIB1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(85)91147-X","article-title":"Autoantibodies against neutrophils and monocytes","volume":"1","author":"van der Woude","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB2","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJM198806233182504","article-title":"Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis","volume":"318","author":"Falk","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB3","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/art.1780330807","article-title":"The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis","volume":"33","author":"Leavitt","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB4","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/art.1780330806","article-title":"The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis)","volume":"33","author":"Masi","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB5","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/art.1780330810","article-title":"The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis","volume":"33","author":"Hunder","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/art.1780370206","article-title":"Nomenclature of systemic vasculitides. Proposal of an international consensus conference","volume":"37","author":"Jennette","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0049-0172(95)80015-8","article-title":"Epidemiology of systemic vasculitis","volume":"25","author":"Watts","year":"1995","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB8","doi-asserted-by":"crossref","first-page":"488","DOI":"10.7326\/0003-4819-116-6-488","article-title":"Wegener granulomatosis","volume":"116","author":"Hoffman","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB9","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/art.11075","article-title":"Limited versus severe Wegener's Granulomatosis","volume":"48","author":"Stone","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"7 pt 1","key":"10.1016\/j.amjmed.2004.02.030_BIB10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1288\/00005537-198207000-00001","article-title":"Ear disease in patients with Wegener's granulomatosis","volume":"92","author":"Kornblut","year":"1982","journal-title":"Laryngoscope"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2273.1989.tb00403.x","article-title":"Ear involvement in Wegener's granulomatosis","volume":"14","author":"Kempf","year":"1989","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB12","first-page":"359","article-title":"Wegener's granulomatosis presenting as vertigo","volume":"146","author":"Bennett","year":"1987","journal-title":"West J Med"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00002281-200001000-00006","article-title":"Immune-mediated sensorineural hearing loss","volume":"12","author":"Stone","year":"2000","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB14","first-page":"477","article-title":"Allergic granulomatosis and angiitis (Churg-Strauss syndrome)","volume":"52","author":"Chumbley","year":"1977","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00005792-198403000-00001","article-title":"Systemic vasculitis with asthma and eosinophilia","volume":"63","author":"Lanham","year":"1984","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB16","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/art.1780401111","article-title":"Mediastinal mass and hilar adenopathy","volume":"40","author":"George","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1378\/chest.123.1.297","article-title":"Pulmonary interstitial fibrosis as a presenting manifestation in perinuclear antineutrophilic cytoplasmic antibody microscopic polyangiitis","volume":"123","author":"Eschun","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB18","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1046\/j.1523-1755.2000.00080.x","article-title":"Antiproteinase 3- and antimyeloperoxidase-associated vasculitis","volume":"57","author":"Franssen","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB19","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg","year":"1951","journal-title":"Am J Pathol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00005792-199901000-00003","article-title":"Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients","volume":"78","author":"Guillevin","year":"1999","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB21","first-page":"578","article-title":"Imaging evidence of successful multiple immunosuppressive treatment of cerebral involvement in Wegener's granulomatosis","volume":"20","author":"Riccieri","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB22","first-page":"757","article-title":"Churg-Strauss vasculitis with brain involvement following hepatitis B vaccination","volume":"19","author":"Beretta","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB23","first-page":"56","article-title":"An autopsy case of P-ANCA-positive microscopic polyangiitis with multiple cerebral hemorrhagic infarction","volume":"50","author":"Sasaki","year":"1998","journal-title":"No To Shinkei"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB24","first-page":"1485","article-title":"Cardiac valve disease in Wegener's granulomatosis","volume":"23","author":"Greidinger","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB25","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0002-9343(02)01349-9","article-title":"Cases from the Osler Medical Service at Johns Hopkins University","volume":"113","author":"Mishell","year":"2002","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB26","doi-asserted-by":"crossref","first-page":"897","DOI":"10.4065\/74.9.897","article-title":"Acute aortic insufficiency associated with Wegener granulomatosis","volume":"74","author":"Leff","year":"1999","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00005792-199505000-00005","article-title":"Urogenital manifestations of Wegener granulomatosis","volume":"74","author":"Huong","year":"1995","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB28","first-page":"1846","article-title":"Two genitourinary manifestations of Wegener's granulomatosis","volume":"24","author":"Stone","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1096-9896(0000)9999:9999<N\/A::AID-PATH610>3.0.CO;2-I","article-title":"What stuff is this! A historical perspective on fibrinoid necrosis","volume":"191","author":"Bajema","year":"2000","journal-title":"J Pathol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB30","first-page":"195","article-title":"Wegener's granulomatosis in the 1990's\u2014a pulmonary pathologist's perspective","volume":"36","author":"Colby","year":"1993","journal-title":"Monogr Pathol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00000478-199006000-00006","article-title":"Interpretation of head and neck biopsies in Wegener's granulomatosis. A pathologic study of 126 biopsies in 70 patients","volume":"14","author":"Devaney","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1189\/jlb.69.2.177","article-title":"Proteinase 3, Wegener's autoantigen: from gene to antigen","volume":"69","author":"van der Geld","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB33","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1681\/ASN.V75694","article-title":"Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro","volume":"7","author":"Berger","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB34","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1046\/j.1523-1755.2000.00073.x","article-title":"Proteinase 3","volume":"57","author":"Tervaert","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB35","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1046\/j.1365-2249.1999.00799.x","article-title":"Anti-proteinase-3 (PR3) antibodies (C-ANCA) recognize various targets on the human umbilical vein endothelial cell (HUVEC) membrane","volume":"115","author":"De Bandt","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2249.1995.tb06642.x","article-title":"Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3","volume":"102","author":"King","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB37","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1182\/blood.V82.4.1221.1221","article-title":"Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis","volume":"82","author":"Mayet","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB38","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2249.1993.tb08215.x","article-title":"Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells","volume":"94","author":"Mayet","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1365-2249.1996.d01-626.x","article-title":"Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1)","volume":"103","author":"Mayet","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB40","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1046\/j.1523-1755.2000.00048.x","article-title":"ANCA antigens, proteinase 3 and myeloperoxidase, are not expressed in endothelial cells","volume":"57","author":"Pendergraft","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-5793(95)01073-N","article-title":"Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool","volume":"374","author":"Halbwachs-Mecarelli","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB42","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1097\/01.ASN.0000028642.26222.00","article-title":"Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis","volume":"13","author":"Rarok","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1365-2249.2000.01228.x","article-title":"Target antigens for anti-neutrophil cytoplasmic autoantibodies (ANCA) are on the surface of primed and apoptotic but not unstimulated neutrophils","volume":"121","author":"Yang","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB44","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-2141.1995.tb03297.x","article-title":"Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells","volume":"89","author":"Dengler","year":"1995","journal-title":"Br J Haematol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1046\/j.1365-2249.2001.01420.x","article-title":"Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site","volume":"123","author":"Griffith","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB46","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1046\/j.1523-1755.1998.00873.x","article-title":"Clinical evaluation of a capture ELISA for detection of proteinase-3 antineutrophil cytoplasmic antibody","volume":"53","author":"Westman","year":"1998","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB47","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1523-1755.1998.00807.x","article-title":"Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC\/BCR Project for ANCA Assay Standardization","volume":"53","author":"Hagen","year":"1998","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB48","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/rheumatology\/41.5.481","article-title":"Rational use of ANCA in the diagnosis of vasculitis","volume":"41","author":"Wiik","year":"2002","journal-title":"Rheumatology (Oxf)"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB49","doi-asserted-by":"crossref","first-page":"925","DOI":"10.7326\/0003-4819-123-12-199512150-00005","article-title":"The role of antineutrophil cytoplasmic antibody (c-ANCA) testing in the diagnosis of Wegener granulomatosis. A literature review and meta-analysis","volume":"123","author":"Rao","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB50","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/1529-0131(199809)41:9<1521::AID-ART2>3.0.CO;2-A","article-title":"Antineutrophil cytoplasmic antibodies","volume":"41","author":"Hoffman","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB51","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/1529-0131(200009)43:9<2025::AID-ANR13>3.0.CO;2-O","article-title":"Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels","volume":"43","author":"Boomsma","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/art.1780360312","article-title":"Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with Wegener's granulomatosis","volume":"36","author":"Kerr","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB53","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1046\/j.1523-1755.2003.00821.x","article-title":"Serial ANCA titers","volume":"63","author":"Han","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB54","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/ndt\/17.12.2077","article-title":"Anti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis","volume":"17","author":"Stegeman","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/rheumatology\/40.2.147","article-title":"Are antineutrophil cytoplasmic antibodies a marker predictive of relapse in Wegener's granulomatosis? A prospective study","volume":"40","author":"Girard","year":"2001","journal-title":"Rheumatology (Oxf)"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00002281-200201000-00004","article-title":"New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis","volume":"14","author":"Savage","year":"2002","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB57","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1172\/JCI0215918","article-title":"Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice","volume":"110","author":"Xiao","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB58","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/1529-0131(200002)43:2<405::AID-ANR22>3.0.CO;2-5","article-title":"Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis","volume":"43","author":"Choi","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"5 pt 1","key":"10.1016\/j.amjmed.2004.02.030_BIB59","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0091-6749(99)70434-3","article-title":"Differential B- and T-cell activation in Wegener's granulomatosis","volume":"103","author":"Popa","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB60","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1530\/eje.0.1420587","article-title":"Prevalence of positive anti-neutrophil cytoplasmic antibody (ANCA) in patients receiving anti-thyroid medication","volume":"142","author":"Gunton","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB61","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/1529-0131(199810)41:10<1835::AID-ART16>3.0.CO;2-Q","article-title":"Intravenous pulse administration of cyclophosphamide versus daily oral treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitis and renal involvement","volume":"41","author":"Haubitz","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB62","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1093\/ndt\/16.10.2018","article-title":"The value of pulse cyclophosphamide in ANCA-associated vasculitis","volume":"16","author":"de Groot","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB63","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0889-857X(05)70240-4","article-title":"Treatment of Wegener's granulomatosis","volume":"27","author":"Regan","year":"2001","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB64","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1056\/NEJMoa020286","article-title":"A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies","volume":"349","author":"Jayne","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB65","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1002\/1529-0131(199912)42:12<2666::AID-ANR24>3.0.CO;2-E","article-title":"A staged approach to the treatment of Wegener's granulomatosis","volume":"42","author":"Langford","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1056\/NEJM199607043350103","article-title":"Trimethoprim-sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis. Dutch Co-Trimoxazole Wegener Study Group","volume":"335","author":"Stegeman","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB67","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/1529-0131(200105)44:5<1149::AID-ANR197>3.0.CO;2-F","article-title":"Etanercept combined with conventional treatment in Wegener's granulomatosis","volume":"44","author":"Stone","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB68","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/rheumatology\/41.11.1303","article-title":"Effectiveness of TNF-alpha blockade with infliximab in refractory Wegener's granulomatosis","volume":"41","author":"Lamprecht","year":"2002","journal-title":"Rheumatology (Oxf)"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB69","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/rheumatology\/41.10.1126","article-title":"Efficacy of the anti-TNF-alpha antibody infliximab against refractory systemic vasculitides","volume":"41","author":"Bartolucci","year":"2002","journal-title":"Rheumatology (Oxf)"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB70","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0197-2456(02)00209-X","article-title":"Design of the Wegener's Granulomatosis Etanercept Trial (WGET)","volume":"23","year":"2002","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB71","first-page":"1017","article-title":"Treatment of subglottic stenosis, due to Wegener's granulomatosis, with intralesional corticosteroids and dilation","volume":"30","author":"Hoffman","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB72","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/art.1780351113","article-title":"The treatment of Wegener's granulomatosis with glucocorticoids and methotrexate","volume":"35","author":"Hoffman","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2004.02.030_BIB73","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0272-6386(03)00025-8","article-title":"Outcome of ANCA-associated renal vasculitis","volume":"41","author":"Booth","year":"2003","journal-title":"Am J Kidney Dis"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934304002396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934304002396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:29:26Z","timestamp":1757579366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934304002396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0002934304002396"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2004.02.030","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antineutrophil cytoplasmic antibody\u2013associated vasculitides","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2004.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}