{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:40:04Z","timestamp":1761154804669,"version":"3.44.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.amjmed.2005.06.008","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T07:22:41Z","timestamp":1125040961000},"page":"3-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"S","title":["Diagnostic assessment of deep vein thrombosis and pulmonary embolism"],"prefix":"10.1016","volume":"118","author":[{"given":"Geno","family":"Merli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2005.06.008_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-125-1-199607010-00001","article-title":"The long-term clinical course of acute deep venous thrombosis","volume":"125","author":"Prandoni","year":"1996","journal-title":"Ann Intern Med"},{"issue":"Suppl 8","key":"10.1016\/j.amjmed.2005.06.008_bib2","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1016\/j.amjmed.2005.06.007","article-title":"Endovascular management of acute deep vein thrombosis","volume":"118","author":"Blum","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib3","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/archinte.163.14.1711","article-title":"Pulmonary embolism mortality in the United States, 1979\u20131998","volume":"163","author":"Horlander","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000068427","article-title":"Principle mechanisms underlying venous thromboembolism","volume":"70","author":"Kroegel","year":"2003","journal-title":"Respiration"},{"key":"10.1016\/j.amjmed.2005.06.008_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjmed.2004.01.018","article-title":"Deep vein thrombosis and pulmonary embolism in two cohorts","volume":"117","author":"Cushman","year":"2004","journal-title":"Am J Med"},{"issue":"suppl 3","key":"10.1016\/j.amjmed.2005.06.008_bib6","first-page":"250","article-title":"Pathophysiology of venous thromboembolism","volume":"17","author":"Nielsen","year":"1991","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.amjmed.2005.06.008_bib7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/archinte.164.9.963","article-title":"Risk factors for venous thromboembolism in hospitalized patients with acute medical illness","volume":"164","author":"Alikhan","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1160\/TH03-07-0481","article-title":"Is prolonged immobilization a risk factor for symptomatic venous thromboembolism in elderly bedridden patients?","volume":"91","author":"Gatt","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.amjmed.2005.06.008_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0025-6196(11)64664-8","article-title":"Concise review for primary-care physicians","volume":"70","author":"Rosenow","year":"1995","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjmed.2005.06.008_bib10","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1200\/JCO.2003.10.111","article-title":"Inherited and acquired risk factors for venous thromboembolic disease among women taking tamoxifen to prevent breast cancer","volume":"21","author":"Duggan","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjmed.2005.06.008_bib11","first-page":"1410","article-title":"Quantification of risk factors for venous thromboembolism","volume":"88","author":"Samama","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.amjmed.2005.06.008_bib12","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/01.sla.0000137138.40116.6c","article-title":"Thromboembolism after trauma","volume":"240","author":"Knudson","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.amjmed.2005.06.008_bib13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1538-7933.2004.00619.x","article-title":"Incidence and prognosis of cancer associated with bilateral venous thrombosis","volume":"2","author":"Bura","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.amjmed.2005.06.008_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/archinte.160.6.769","article-title":"Recurrent venous thromboembolism after deep vein thrombosis","volume":"160","author":"Hansson","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib15","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1056\/NEJM199506223322501","article-title":"A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism","volume":"332","author":"Schulman","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0140-6736(93)90003-Y","article-title":"Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect","volume":"341","author":"Allaart","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.amjmed.2005.06.008_bib17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.0001-6349.2004.0533.x","article-title":"Pulmonary embolism associated with combined oral contraceptives","volume":"83","author":"Hedenmalm","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.amjmed.2005.06.008_bib18","first-page":"41","article-title":"Hypercoagulability and venous thromboembolism","volume":"103","author":"Mazza","year":"2004","journal-title":"WMJ"},{"key":"10.1016\/j.amjmed.2005.06.008_bib19","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1002\/cncr.20150","article-title":"ABO blood group is a potent risk factor for venous thromboembolism in patients with malignant gliomas","volume":"100","author":"Streiff","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.amjmed.2005.06.008_bib20","first-page":"95","article-title":"Epidemiology, etiology and diagnosis of venous thrombosis","volume":"9","author":"Gathof","year":"2004","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.amjmed.2005.06.008_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/archsurg.1976.01360190036005","article-title":"The diagnosis of deep venous thrombosis","volume":"111","author":"Cranley","year":"1976","journal-title":"Arch Surg"},{"key":"10.1016\/j.amjmed.2005.06.008_bib22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1001\/archinte.159.5.477","article-title":"Thrombosis in the emergency department","volume":"159","author":"Anderson","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib23","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1160\/TH03-02-0080","article-title":"Rapid d-dimer test combined a clinical model for deep vein thrombosis","volume":"91","author":"Ruiz-Gim\u00e9nez","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.amjmed.2005.06.008_bib24","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/S0140-6736(95)92535-X","article-title":"Accuracy of clinical assessment of deep-vein thrombosis","volume":"345","author":"Wells","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.amjmed.2005.06.008_bib25","doi-asserted-by":"crossref","first-page":"997","DOI":"10.7326\/0003-4819-129-12-199812150-00002","article-title":"Use of a clinical model for safe management of patients with suspected pulmonary embolism","volume":"129","author":"Wells","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib26","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1055\/s-2000-13219","article-title":"Assessment of deep vein thrombosis or pulmonary embolism by the combined use of clinical model and noninvasive diagnostic tests","volume":"26","author":"Wells","year":"2000","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.amjmed.2005.06.008_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.7326\/0003-4819-135-2-200107170-00010","article-title":"Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer","volume":"135","author":"Wells","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib28","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1164\/ajrccm.160.3.16030","article-title":"The diagnostic approach to acute venous thromboembolism","volume":"160","author":"Tapson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib29","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1378\/chest.100.3.598","article-title":"Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease","volume":"100","author":"Stein","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.amjmed.2005.06.008_bib30","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0025-7125(05)70005-5","article-title":"Diagnosis of deep venous thrombosis and pulmonary embolism","volume":"82","author":"Baker","year":"1998","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.amjmed.2005.06.008_bib31","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ejvs.2003.12.021","article-title":"Extended lower limb venous ultrasound for the diagnosis of proximal and distal vein thrombosis in asymptomatic patients after total hip replacement","volume":"27","author":"Elias","year":"2004","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.amjmed.2005.06.008_bib32","doi-asserted-by":"crossref","first-page":"985","DOI":"10.7326\/0003-4819-140-12-200406150-00007","article-title":"Withholding anticoagulation after a negative result on duplex ultrasonography for suspected symptomatic deep venous thrombosis","volume":"140","author":"Stevens","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib33","first-page":"214","article-title":"Electrocardiographic features in critical pulmonary embolism","volume":"5","author":"Costantini","year":"2004","journal-title":"Ital Heart J"},{"key":"10.1016\/j.amjmed.2005.06.008_bib34","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0002-9149(00)01090-0","article-title":"Diagnostic value of the electrocardiogram in suspected pulmonary embolism","volume":"86","author":"Rodger","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2005.06.008_bib35","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1378\/chest.125.5.1651","article-title":"ECG score predicts those with the greatest percentage of perfusion defects due to acute pulmonary thromboembolic disease","volume":"125","author":"Iles","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.amjmed.2005.06.008_bib36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1148\/radiology.210.2.r99fe53353","article-title":"Acute pulmonary embolism","volume":"210","author":"Gupta","year":"1999","journal-title":"Radiology"},{"key":"10.1016\/j.amjmed.2005.06.008_bib37","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1001\/jama.1990.03440200057023","article-title":"Value of the ventilation\/perfusion scan in acute pulmonary embolism","volume":"263","year":"1990","journal-title":"JAMA"},{"key":"10.1016\/j.amjmed.2005.06.008_bib38","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1259\/bjr.70.839.9536900","article-title":"Clinicians\u2019 interpretation of the indeterminate ventilation-perfusion scan report","volume":"70","author":"Kember","year":"1997","journal-title":"Br J Radiol"},{"key":"10.1016\/j.amjmed.2005.06.008_bib39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1148\/radiology.205.2.9356627","article-title":"Pulmonary embolism","volume":"205","author":"Mayo","year":"1997","journal-title":"Radiology"},{"key":"10.1016\/j.amjmed.2005.06.008_bib40","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1148\/radiology.200.3.8756918","article-title":"Diagnosis of pulmonary embolism with spiral CT","volume":"200","author":"Remy-Jardin","year":"1996","journal-title":"Radiology"},{"key":"10.1016\/j.amjmed.2005.06.008_bib41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.7326\/0003-4819-135-2-200107170-00008","article-title":"Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism","volume":"135","author":"Perrier","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1148\/radiol.2232010913","article-title":"Risk of pulmonary embolism after a negative spiral CT angiogram in patients with pulmonary disease","volume":"223","author":"Tillie-Leblond","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.amjmed.2005.06.008_bib43","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1161\/01.CIR.85.2.462","article-title":"Complications and validity of pulmonary angiography in acute pulmonary embolism","volume":"85","author":"Stein","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2005.06.008_bib44","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1001\/archinte.1993.00410120005001","article-title":"When can treatment be withheld in patients with suspected pulmonary embolism?","volume":"153","author":"Dalen","year":"1993","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1164\/ajrccm\/141.1.235","article-title":"Venous thromboembolism","volume":"141","author":"Moser","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.amjmed.2005.06.008_bib46","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1046\/j.1538-7836.2003.00231.x","article-title":"Contribution of indirect computed tomography venography to computed tomography angiography of the chest for the diagnosis of thromboembolic disease in two United States emergency departments","volume":"1","author":"Richman","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.amjmed.2005.06.008_bib47","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1148\/radiology.216.3.r00se44744","article-title":"Deep venous thrombosis","volume":"216","author":"Cham","year":"2000","journal-title":"Radiology"},{"key":"10.1016\/j.amjmed.2005.06.008_bib48","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1148\/radiology.219.2.r01ma26498","article-title":"Deep venous thrombosis with suspected pulmonary embolism","volume":"219","author":"Loud","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.amjmed.2005.06.008_bib49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7326\/0003-4819-136-2-200201150-00006","article-title":"Diagnosis of lower-limb deep venous thrombosis","volume":"136","author":"Fraser","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib50","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1046\/j.1538-7836.2003.00333.x","article-title":"Magnetic resonance direct thrombus imaging","volume":"1","author":"Moody","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.amjmed.2005.06.008_bib51","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1055\/s-0037-1613461","article-title":"Magnetic resonance direct thrombus imaging","volume":"89","author":"Kelly","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.amjmed.2005.06.008_bib52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0196-0644(00)70130-2","article-title":"A negative SimpliRED d-dimer assay result does not exclude the diagnosis of deep vein thrombosis or pulmonary embolus in emergency department patients","volume":"35","author":"Farrell","year":"2000","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib53","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0002-9343(02)01520-6","article-title":"Limitations of d-dimer testing in unselected inpatients with suspected venous thromboembolism","volume":"114","author":"Brotman","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib54","doi-asserted-by":"crossref","first-page":"589","DOI":"10.7326\/0003-4819-140-8-200404200-00005","article-title":"d-Dimer for the exclusion of acute venous thrombosis and pulmonary embolism","volume":"140","author":"Stein","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2005.06.008_bib55","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1378\/chest.125.3.851","article-title":"Clinical utility of d-dimer in patients with suspected pulmonary embolism and nondiagnostic lung scans or negative CT findings","volume":"125","author":"Rathbun","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.amjmed.2005.06.008_bib56","first-page":"1143","article-title":"Negative d-dimers and peripheral pulmonary embolism","volume":"96","author":"Mansencal","year":"2003","journal-title":"Arch Mal Coeur Vaiss"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934305004389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934305004389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:38:03Z","timestamp":1757579883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934305004389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0002934305004389"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2005.06.008","relation":{},"ISSN":["0002-9343"],"issn-type":[{"type":"print","value":"0002-9343"}],"subject":[],"published":{"date-parts":[[2005,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic assessment of deep vein thrombosis and pulmonary embolism","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2005.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}