{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:00:18Z","timestamp":1790395218241,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.amjmed.2006.05.002","type":"journal-article","created":{"date-parts":[[2008,4,22]],"date-time":"2008-04-22T20:53:06Z","timestamp":1208897586000},"page":"S4-S11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"special_numbering":"S1","title":["Mechanisms of Cell Volume Regulation in Hypo-osmolality"],"prefix":"10.1016","volume":"119","author":[{"given":"Herminia","family":"Pasantes-Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"Lezama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Ramos-Mandujano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina L.","family":"Tuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2006.05.002_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000016269","article-title":"The diversity of volume regulatory mechanisms","volume":"8","author":"Lang","year":"1998","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.amjmed.2006.05.002_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1095-6433(01)00424-X","article-title":"Apoptosis, cell volume regulation and volume-regulatory chloride channels","volume":"130","author":"Okada","year":"2001","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"issue":"pt 1","key":"10.1016\/j.amjmed.2006.05.002_bib3","doi-asserted-by":"crossref","first-page":"C755","DOI":"10.1152\/ajpcell.1997.273.3.C755","article-title":"Volume expansion-sensing outward-rectifier Cl\u2013 channel","volume":"273","author":"Okada","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.amjmed.2006.05.002_bib4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000045829","article-title":"Influence of calcium on regulatory volume decrease","volume":"86","author":"Pasantes-Morales","year":"2000","journal-title":"Nephron"},{"key":"10.1016\/j.amjmed.2006.05.002_bib5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1095-6433(01)00428-7","article-title":"K+ conductance activated during regulatory volume decrease","volume":"130","author":"Niemeyer","year":"2001","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10.1016\/j.amjmed.2006.05.002_bib6","doi-asserted-by":"crossref","first-page":"C1399","DOI":"10.1152\/ajpcell.00198.2003","article-title":"Volume changes and whole cell membrane currents activated during gradual osmolarity decrease in C6 glioma cells","volume":"286","author":"Ordaz","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.amjmed.2006.05.002_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000016368","article-title":"Organic osmolyte channels","volume":"10","author":"Junankar","year":"2000","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.amjmed.2006.05.002_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/B:NERE.0000010433.08577.96","article-title":"Regulation of the cellular content of the organic osmolyte taurine in mammalian cells","volume":"29","author":"Lambert","year":"2004","journal-title":"Neurochem Res"},{"key":"10.1016\/j.amjmed.2006.05.002_bib9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0006-8993(91)90806-7","article-title":"Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats","volume":"567","author":"Verbalis","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.amjmed.2006.05.002_bib10","first-page":"F661","article-title":"Volume regulatory loss of Na, Cl, and K from rat brain during acute hyponatremia","volume":"252","author":"Melton","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1016\/j.amjmed.2006.05.002_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0955-0674(99)80024-6","article-title":"Epidermal growth factor receptors","volume":"11","author":"Hackel","year":"1999","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.amjmed.2006.05.002_bib12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1667\/0033-7587(2003)159[0283:SARIAO]2.0.CO;2","article-title":"Stress and radiation-induced activation of multiple intracellular signaling pathways","volume":"159","author":"Dent","year":"2003","journal-title":"Radiat Res"},{"key":"10.1016\/j.amjmed.2006.05.002_bib13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s00424-003-1211-z","article-title":"Epidermal growth factor receptor is activated by hyposmolarity and is an early signal modulating osmolyte efflux pathways in Swiss 3T3 fibroblasts","volume":"447","author":"Franco","year":"2004","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"10.1016\/j.amjmed.2006.05.002_bib14","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1471-4159.2005.03110.x","article-title":"Hyposmolarity-induced ErbB4 phosphorylation and its influence on the non-receptor tyrosine kinase network response in cultured cerebellar granule neurons","volume":"93","author":"Lezama","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.amjmed.2006.05.002_bib15","doi-asserted-by":"crossref","first-page":"19919","DOI":"10.1016\/S0021-9258(20)80672-3","article-title":"Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances","volume":"268","author":"Tilly","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.amjmed.2006.05.002_bib16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00424-005-1456-9","article-title":"TRPV4 and the mammalian kidney","volume":"451","author":"Cohen","year":"2005","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"10.1016\/j.amjmed.2006.05.002_bib17","doi-asserted-by":"crossref","first-page":"11520","DOI":"10.1074\/jbc.M211061200","article-title":"Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation","volume":"278","author":"Xu","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.amjmed.2006.05.002_bib18","doi-asserted-by":"crossref","first-page":"27088","DOI":"10.1074\/jbc.M210699200","article-title":"Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver","volume":"278","author":"vom Dahl","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.amjmed.2006.05.002_bib19","doi-asserted-by":"crossref","first-page":"C483","DOI":"10.1152\/ajpcell.00452.2004","article-title":"SRC family kinases in cell volume regulation","volume":"288","author":"Cohen","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.amjmed.2006.05.002_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0006-8993(95)00778-O","article-title":"Hypotonic exposure enhances synaptic transmission and triggers spreading depression in rat hippocampal tissue slices","volume":"695","author":"Chebabo","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.amjmed.2006.05.002_bib21","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.0953-816X.2004.03209.x","article-title":"Depolarization, exocytosis and amino acid release evoked by hyposmolarity from cortical synaptosomes","volume":"19","author":"Tuz","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.amjmed.2006.05.002_bib22","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1111\/j.1460-9568.2005.04344.x","article-title":"Hyposmolarity evokes norepinephrine efflux from synaptosomes by a depolarization- and Ca2+-dependent exocytotic mechanism","volume":"22","author":"Tuz","year":"2005","journal-title":"Eur J Neurosci"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934306004888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934306004888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:42:06Z","timestamp":1757580126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934306004888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0002934306004888"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2006.05.002","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of Cell Volume Regulation in Hypo-osmolality","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2006.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}