{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:30:25Z","timestamp":1791639025676,"version":"4.3.4"},"reference-count":13,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.amjmed.2006.05.010","type":"journal-article","created":{"date-parts":[[2008,4,22]],"date-time":"2008-04-22T20:53:06Z","timestamp":1208897586000},"page":"S69-S73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"S1","title":["Mechanisms and Therapy of Osmotic Demyelination"],"prefix":"10.1016","volume":"119","author":[{"given":"Takashi","family":"Murase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Takefuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Oiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2006.05.010_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.7326\/0003-4819-126-1-199701010-00008","article-title":"Myelinolysis after correction of hyponatremia","volume":"126","author":"Laureno","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2006.05.010_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1468-1331.2001.00176.x","article-title":"A review of the causes of central pontine myelinosis","volume":"8","author":"Ashrafian","year":"2001","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.amjmed.2006.05.010_bib3","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1681\/ASN.V481522","article-title":"Neurologic sequelae after treatment of severe hyponatremia","volume":"4","author":"Sterns","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjmed.2006.05.010_bib4","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM200005253422107","article-title":"Hyponatremia","volume":"342","author":"Adrogue","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2006.05.010_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000047939","article-title":"Central pontine myelinolysis","volume":"47","author":"Lampl","year":"2002","journal-title":"Eur Neurol"},{"key":"10.1016\/j.amjmed.2006.05.010_bib6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0002-9343(94)90166-X","article-title":"Osmotic demyelination syndrome following correction of hyponatremia","volume":"96","author":"Lohr","year":"1994","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2006.05.010_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(95)00245-L","article-title":"Effect of rapid correction of hyponatremia on the blood-brain barrier of rats","volume":"679","author":"Adler","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.amjmed.2006.05.010_bib8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0006-8993(91)90806-7","article-title":"Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats","volume":"567","author":"Verbalis","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.amjmed.2006.05.010_bib9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/exnr.2000.7474","article-title":"Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia","volume":"165","author":"Baker","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1016\/j.amjmed.2006.05.010_bib10","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ki.1991.161","article-title":"Neurological and neuropathological sequelae of correction of chronic hyponatremia","volume":"39","author":"Verbalis","year":"1991","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjmed.2006.05.010_bib11","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1073\/pnas.79.14.4420","article-title":"Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent","volume":"79","author":"Neuwelt","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.amjmed.2006.05.010_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.expneurol.2004.10.018","article-title":"Protective effect of dexamethasone on osmotic-induced demyelination in rats","volume":"192","author":"Sugimura","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.amjmed.2006.05.010_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00000441-200307000-00004","article-title":"Treatment of symptomatic hyponatremia","volume":"326","author":"Decaux","year":"2003","journal-title":"Am J Med Sci"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934306004967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934306004967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:42:30Z","timestamp":1757580150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934306004967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0002934306004967"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2006.05.010","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms and Therapy of Osmotic Demyelination","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2006.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}