{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:04:54Z","timestamp":1791295494858,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.amjmed.2009.07.034","type":"journal-article","created":{"date-parts":[[2010,4,16]],"date-time":"2010-04-16T04:44:40Z","timestamp":1271393080000},"page":"393-399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Utility of Biomarkers in Sorting Out the Complex Patient"],"prefix":"10.1016","volume":"123","author":[{"given":"Christopher","family":"Moriates","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Maisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2009.07.034_bib1","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.2337\/diacare.27.10.2444","article-title":"Increasing prevalence of the metabolic syndrome among U.S. adults","volume":"27","author":"Ford","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.amjmed.2009.07.034_bib2","first-page":"e25","article-title":"Heart disease and stroke statistics\u20142008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"117","author":"Rosamond","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2009.07.034_bib3","author":"Fonarow"},{"key":"10.1016\/j.amjmed.2009.07.034_bib4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1681\/ASN.2004070539","article-title":"Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000","volume":"16","author":"Coresh","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib5","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1089\/jwh.1998.7.1125","article-title":"Prevalence of multiple cardiovascular disease risk factors among women in the United States, 1992 and 1995: the Behavioral Risk Factor Surveillance System","volume":"7","author":"Greenlund","year":"1998","journal-title":"J Womens Health"},{"key":"10.1016\/j.amjmed.2009.07.034_bib6","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1056\/NEJM200004203421607","article-title":"Evaluation of the patient with acute chest pain","volume":"342","author":"Lee","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2009.07.034_bib7","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1056\/NEJMsa0803563","article-title":"Rehospitalizations among patients in the Medicare fee-for-service program","volume":"360","author":"Jencks","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2009.07.034_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ejheart.2003.12.014","article-title":"Reduced readmission rate for alternating diagnoses of heart failure and pulmonary disease after implementation of B-type natriuretic peptide testing","volume":"6","author":"Wu","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.amjmed.2009.07.034_bib9","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.jacc.2007.09.021","article-title":"Natriuretic peptides","volume":"50","author":"Daniels","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJMoa020233","article-title":"Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure","volume":"347","author":"Maisel","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2009.07.034_bib11","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1056\/NEJMoa031681","article-title":"Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea","volume":"350","author":"Mueller","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2009.07.034_bib12","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1161\/CIRCULATIONAHA.106.666255","article-title":"N-terminal pro-B-type natriuretic peptide testing improves the management of patients with suspected acute heart failure: primary results of the Canadian prospective randomized multicenter IMPROVE-CHF study","volume":"115","author":"Moe","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2009.07.034_bib13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.CIR.0000025242.79963.4C","article-title":"B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study","volume":"106","author":"McCullough","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2009.07.034_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1023\/A:1026139130208","article-title":"Use of BNP levels in monitoring hospitalized heart failure patients with heart failure","volume":"8","author":"Maisel","year":"2003","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.amjmed.2009.07.034_bib15","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/S0735-1097(03)00405-4","article-title":"Bedside B-Type natriuretic peptide in the emergency diagnosis of heart failure with reduced or preserved ejection fraction","volume":"41","author":"Maisel","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0735-1097(00)01156-6","article-title":"Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting","volume":"37","author":"Dao","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib17","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.amjcard.2008.07.018","article-title":"Association between renal function and circulating levels of natriuretic peptides (from the Dallas Heart Study)","volume":"102","author":"Das","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib18","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1373\/clinchem.2005.065441","article-title":"Midregional pro-A-type natriuretic peptide measurements for diagnosis of acute destabilized heart failure in short-of-breath patients: comparison with B-type natriuretic peptide (BNP) and amino-terminal proBNP","volume":"52","author":"Gegenhuber","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjmed.2009.07.034_bib19","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.jacc.2007.08.012","article-title":"Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure","volume":"50","author":"von Haehling","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib20","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jacc.2007.04.091","article-title":"Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure","volume":"50","author":"Kempf","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib21","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/CIRCULATIONAHA.106.650846","article-title":"Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome","volume":"115","author":"Wollert","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2009.07.034_bib22","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jacc.2006.03.061","article-title":"Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure","volume":"48","author":"van Kimmenade","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib23","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jacc.2008.07.045","article-title":"Serum soluble ST2 as a biochemical marker of acute heart failure: future areas of research","volume":"52","author":"Diez","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib24","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jacc.2008.07.042","article-title":"Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure","volume":"52","author":"Rehman","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib25","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1161\/CIRCULATIONAHA.107.728022","article-title":"Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction","volume":"117","author":"Sabatine","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2009.07.034_bib26","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/CCM.0B013E318165BABB","article-title":"Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations","volume":"36","author":"Becker","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.amjmed.2009.07.034_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1378\/chest.06-1500","article-title":"Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy","volume":"131","author":"Stolz","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.amjmed.2009.07.034_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11908-007-0037-9","article-title":"Procalcitonin and pneumonia: is it a useful marker?","volume":"9","author":"Christ-Crain","year":"2007","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.amjmed.2009.07.034_bib29","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1093\/eurheartj\/ehm355","article-title":"Universal definition of myocardial infarction","volume":"28","author":"Thygesen","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjmed.2009.07.034_bib30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1373\/clinchem.2006.076885","article-title":"Long-term health outcomes associated with detectable troponin I concentrations","volume":"53","author":"Kavsak","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjmed.2009.07.034_bib31","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1056\/NEJMoa035003","article-title":"Prognostic value of myeloperoxidase in patients with chest pain","volume":"349","author":"Brennan","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2009.07.034_bib32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/j.ajkd.2008.01.020","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage","volume":"52","author":"Bolignano","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.amjmed.2009.07.034_bib33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/FJC.0b013e31819d6139","article-title":"Rapid detection of acute kidney injury by plasma and urinary neutrophil gelatinase-associated lipocalin after cardiopulmonary bypass","volume":"53","author":"Tuladhar","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1159\/000109102","article-title":"Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values?","volume":"30","author":"Bachorzewska-Gajewska","year":"2007","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.amjmed.2009.07.034_bib35","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00467-006-0146-y","article-title":"Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injury","volume":"21","author":"Trachtman","year":"2006","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.amjmed.2009.07.034_bib36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000143726","article-title":"Neutrophil gelatinase-associated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney disease","volume":"31","author":"Bolignano","year":"2008","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.amjmed.2009.07.034_bib37","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7326\/0003-4819-148-11-200806030-00003","article-title":"Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury","volume":"148","author":"Nickolas","year":"2008","journal-title":"Ann Intern Med"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934309011036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934309011036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:52:58Z","timestamp":1757580778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934309011036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0002934309011036"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2009.07.034","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Utility of Biomarkers in Sorting Out the Complex Patient","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2009.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Excerpta Medica Inc.","name":"copyright","label":"Copyright"}]}}