{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:46:08Z","timestamp":1786362368975,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.amjmed.2011.10.031","type":"journal-article","created":{"date-parts":[[2012,4,6]],"date-time":"2012-04-06T07:22:07Z","timestamp":1333696927000},"page":"491-498.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Determinants of High-Sensitivity Troponin T Among Patients with a Noncardiac Cause of Chest Pain"],"prefix":"10.1016","volume":"125","author":[{"given":"Affan","family":"Irfan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Stelzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Haaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willibald","family":"Hochholzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Steuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Zellweger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Freidank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Campodarve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Meune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"386","key":"10.1016\/j.amjmed.2011.10.031_bib1","first-page":"1","article-title":"National Hospital Ambulatory Medical Care Survey: 2005 emergency department summary","author":"Nawar","year":"2007","journal-title":"Adv Data"},{"key":"10.1016\/j.amjmed.2011.10.031_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2217\/bmm.10.60","article-title":"Clinical application of sensitive cardiac troponin assays: potential and limitations","volume":"4","author":"Twerenbold","year":"2010","journal-title":"Biomark Med"},{"key":"10.1016\/j.amjmed.2011.10.031_bib3","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1161\/CIRCULATIONAHA.107.708529","article-title":"Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality","volume":"116","author":"Eggers","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2011.10.031_bib4","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/CIRCULATIONAHA.105.570762","article-title":"Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study","volume":"113","author":"Zethelius","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2011.10.031_bib5","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.amjcard.2007.03.096","article-title":"Usefulness of detectable levels of troponin, below the 99th percentile of the normal range, as a clue to the presence of underlying coronary artery disease","volume":"100","author":"Schulz","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2011.10.031_bib6","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1056\/NEJMoa0805299","article-title":"A sensitive cardiac troponin T assay in stable coronary artery disease","volume":"361","author":"Omland","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2011.10.031_bib7","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1161\/CIRCULATIONAHA.110.005264","article-title":"Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study","volume":"123","author":"Saunders","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2011.10.031_bib8","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1001\/jama.2010.1768","article-title":"Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population","volume":"304","author":"de Lemos","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.amjmed.2011.10.031_bib9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1373\/clinchem.2009.136218","article-title":"High-sensitivity cardiac troponin: hype, help, and reality","volume":"56","author":"Jaffe","year":"2010","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjmed.2011.10.031_bib10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.ahj.2010.03.018","article-title":"Higher sensitivity troponin levels in the community: what do they mean and how will the diagnosis of myocardial infarction be made?","volume":"159","author":"White","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjmed.2011.10.031_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/CRD.0b013e3181c42f96","article-title":"Clinical applications of highly sensitive troponin assays","volume":"18","author":"Mohammed","year":"2010","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.amjmed.2011.10.031_bib12","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1373\/clinchem.2006.084194","article-title":"National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes","volume":"53","author":"Morrow","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjmed.2011.10.031_bib13","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1056\/NEJMoa0900428","article-title":"Early diagnosis of myocardial infarction with sensitive cardiac troponin assays","volume":"361","author":"Reichlin","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2011.10.031_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jacc.2009.01.076","article-title":"Incremental value of copeptin for rapid rule out of acute myocardial infarction","volume":"54","author":"Reichlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2011.10.031_bib15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1373\/clinchem.2009.132654","article-title":"Analytical validation of a high-sensitivity cardiac troponin T assay","volume":"56","author":"Giannitsis","year":"2010","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjmed.2011.10.031_bib16","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1309\/Q9W5HJTT24GQCXXX","article-title":"Earlier detection of myocardial injury in a preliminary evaluation using a new troponin I assay with improved sensitivity","volume":"128","author":"Melanson","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.amjmed.2011.10.031_bib17","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1373\/clinchem.2007.097162","article-title":"Use of the Centaur TnI-Ultra assay for detection of myocardial infarction and adverse events in patients presenting with symptoms suggestive of acute coronary syndrome","volume":"54","author":"Apple","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.amjmed.2011.10.031_bib18","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/eurheartj\/ehq251","article-title":"Recommendations for the use of cardiac troponin measurement in acute cardiac care","volume":"31","author":"Thygesen","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjmed.2011.10.031_bib19","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1161\/CIRCULATIONAHA.107.187397","article-title":"Universal definition of myocardial infarction","volume":"116","author":"Thygesen","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2011.10.031_bib20","first-page":"e352","article-title":"National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes","volume":"115","author":"Apple","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2011.10.031_bib21","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1056\/NEJMra054415","article-title":"Assessing kidney function\u2013measured and estimated glomerular filtration rate","volume":"354","author":"Stevens","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2011.10.031_bib22","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/ATVBAHA.109.200394","article-title":"The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T","volume":"30","author":"Laufer","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjmed.2011.10.031_bib23","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1161\/CIRCULATIONAHA.109.893826","article-title":"High-sensitivity troponin T concentrations in acute chest pain patients evaluated with cardiac computed tomography","volume":"121","author":"Januzzi","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2011.10.031_bib24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1475-2840-9-52","article-title":"Determinants and prognostic implications of cardiac troponin T measured by a sensitive assay in type 2 diabetes mellitus","volume":"9","author":"Hallen","year":"2010","journal-title":"Cardiovasc Diabetol"},{"issue":"Pt 4","key":"10.1016\/j.amjmed.2011.10.031_bib25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1258\/acb.2009.008197","article-title":"Haemodialysis patients longitudinally assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and cardiac troponin I assays","volume":"46","author":"Jacobs","year":"2009","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.amjmed.2011.10.031_bib26","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ejechocard\/jep063","article-title":"Association between troponin T and impaired left ventricular relaxation in patients with acute decompensated heart failure with preserved systolic function","volume":"10","author":"Shah","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.amjmed.2011.10.031_bib27","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1002\/clc.20622","article-title":"Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophic cardiomyopathy","volume":"33","author":"Kubo","year":"2010","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.amjmed.2011.10.031_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00134-010-2051-x","article-title":"Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome","volume":"37","author":"Rosjo","year":"2011","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.amjmed.2011.10.031_bib29","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/eurheartj\/ehq234","article-title":"Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism","volume":"31","author":"Lankeit","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.amjmed.2011.10.031_bib30","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s00059-009-3306-6","article-title":"Troponins and high-sensitivity troponins as markers of necrosis in CAD and heart failure","volume":"34","author":"Giannitsis","year":"2009","journal-title":"Herz"},{"key":"10.1016\/j.amjmed.2011.10.031_bib31","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.amjcard.2008.04.036","article-title":"Relation of cardiac troponin I levels with in-hospital mortality in patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage","volume":"102","author":"Sandhu","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2011.10.031_bib32","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/eurheartj\/ehr033","article-title":"Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays","volume":"32","author":"Reiter","year":"2011","journal-title":"Eur Heart J"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293431200006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293431200006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:59:25Z","timestamp":1757581165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293431200006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S000293431200006X"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2011.10.031","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determinants of High-Sensitivity Troponin T Among Patients with a Noncardiac Cause of Chest Pain","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2011.10.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}