{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:48:40Z","timestamp":1789958920502,"version":"4.0.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.amjmed.2012.01.012","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T20:48:24Z","timestamp":1335991704000},"page":"704-708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Safety of Symptom-limited Cardiopulmonary Exercise Testing in Patients with Aortic Stenosis"],"prefix":"10.1016","volume":"125","author":[{"given":"Abhijeet","family":"Dhoble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice E.","family":"Sarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Kopecky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney L.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2012.01.012_bib1","first-page":"204","article-title":"Value of exercise testing to evaluate the indication for surgery in asymptomatic patients with valvular aortic stenosis","volume":"11","author":"Alborino","year":"2002","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.amjmed.2012.01.012_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/heart.86.4.381","article-title":"Treatment decision in asymptomatic aortic valve stenosis: role of exercise testing","volume":"86","author":"Amato","year":"2001","journal-title":"Heart"},{"key":"10.1016\/j.amjmed.2012.01.012_bib3","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/eurheartj\/ehi250","article-title":"Exercise testing to stratify risk in aortic stenosis","volume":"26","author":"Das","year":"2005","journal-title":"Eur Heart J"},{"issue":"9 Suppl","key":"10.1016\/j.amjmed.2012.01.012_bib4","first-page":"I377","article-title":"Prognostic importance of quantitative exercise Doppler echocardiography in asymptomatic valvular aortic stenosis","volume":"112","author":"Lancellotti","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2012.01.012_bib5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1540-8175.2007.00501.x","article-title":"Left ventricular response to exercise in aortic stenosis: an exercise echocardiographic study","volume":"24","author":"Marechaux","year":"2007","journal-title":"Echocardiography"},{"key":"10.1016\/j.amjmed.2012.01.012_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000096953","article-title":"Exercise testing in asymptomatic aortic stenosis","volume":"108","author":"Peidro","year":"2007","journal-title":"Cardiology"},{"key":"10.1016\/j.amjmed.2012.01.012_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0167-5273(01)00544-7","article-title":"Prediction of symptom-onset in aortic stenosis: a comparison of pressure drop\/flow slope and haemodynamic measures at rest","volume":"81","author":"Takeda","year":"2001","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib8","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0735-1097(86)80208-X","article-title":"Guidelines for exercise testing","volume":"8","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib9","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2006.05.021","volume":"48","author":"Bonow","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib10","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0735-1097(02)02164-2","article-title":"ACC\/AHA 2002 guideline update for exercise testing: summary article","volume":"40","author":"Gibbons","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib11","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/0735-1097(90)90234-G","article-title":"The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis","volume":"15","author":"Pellikka","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib12","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1161\/CIRCULATIONAHA.104.495903","article-title":"Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up","volume":"111","author":"Pellikka","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2012.01.012_bib13","first-page":"165","article-title":"Prevalence of atherosclerosis of the coronary and extracranial cerebral arteries in patients undergoing aortic valve replacement for calcified stenosis","volume":"15","author":"Kaden","year":"2006","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.amjmed.2012.01.012_bib14","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease","volume":"29","author":"Stewart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/01.CIR.96.1.345","article-title":"ACC\/AHA guidelines for exercise testing: executive summary","volume":"96","author":"Gibbons","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2012.01.012_bib16","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.amjcard.2009.02.013","article-title":"Predictive value of heart rate recovery and peak oxygen consumption for long-term mortality in patients with coronary heart disease","volume":"103","author":"Aijaz","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib17","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.amjcard.2009.12.053","article-title":"Usefulness of cardiac index and peak exercise oxygen consumption for determining priority for cardiac transplantation","volume":"105","author":"Methvin","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib18","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1161\/01.CIR.92.12.3593","article-title":"Selection and treatment of candidates for heart transplantation","volume":"92","author":"Costanzo","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2012.01.012_bib19","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S0735-1097(00)00816-0","article-title":"Utility of metabolic exercise testing in distinguishing hypertrophic cardiomyopathy from physiologic left ventricular hypertrophy in athletes","volume":"36","author":"Sharma","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2012.01.012_bib20","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1161\/01.CIR.102.13.1591","article-title":"Assessment of functional capacity in clinical and research applications: an advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association","volume":"102","author":"Fleg","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2012.01.012_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00008483-199907000-00006","article-title":"Non-physician supervision of cardiopulmonary exercise testing in chronic heart failure: safety and results of a preliminary investigation","volume":"19","author":"Squires","year":"1999","journal-title":"J Cardiopulm Rehabil"},{"key":"10.1016\/j.amjmed.2012.01.012_bib22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4065\/71.5.445","article-title":"Peak exercise blood pressure stratified by age and gender in apparently healthy subjects","volume":"71","author":"Daida","year":"1996","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjmed.2012.01.012_bib23","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1161\/01.CIR.0000136811.45524.2F","article-title":"Cardiopulmonary exercise testing: how do we differentiate the cause of dyspnea?","volume":"110","author":"Milani","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2012.01.012_bib24","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(09)60211-7","article-title":"Aortic stenosis","volume":"373","author":"Carabello","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.amjmed.2012.01.012_bib25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/eurheartj\/ehp575","article-title":"Risk stratification of patients with aortic stenosis","volume":"31","author":"Vahanian","year":"2010","journal-title":"Eur Heart J"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934312000812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934312000812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:58:14Z","timestamp":1757581094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934312000812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0002934312000812"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2012.01.012","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of Symptom-limited Cardiopulmonary Exercise Testing in Patients with Aortic Stenosis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2012.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}