{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:11:49Z","timestamp":1788786709589,"version":"build-2803163510"},"reference-count":20,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.amjmed.2013.02.014","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T08:04:51Z","timestamp":1370851491000},"page":"665-669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Treatment Trials for Post-Lyme Disease Symptoms Revisited"],"prefix":"10.1016","volume":"126","author":[{"given":"Mark S.","family":"Klempner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene D.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Dattwyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Wormser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2013.02.014_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1056\/NEJM200107123450202","article-title":"Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease","volume":"345","author":"Klempner","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjmed.2013.02.014_bib2","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1212\/01.WNL.0000068030.26992.25","article-title":"Cognitive function in post-treatment Lyme disease. Do additional antibiotics help?","volume":"60","author":"Kaplan","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.amjmed.2013.02.014_bib3","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1212\/01.WNL.0000071227.23769.9E","article-title":"Study and treatment of post Lyme disease (Stop-LD). A randomized double-masked clinical trial","volume":"60","author":"Krupp","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.amjmed.2013.02.014_bib4","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1212\/01.WNL.0000284604.61160.2d","article-title":"A\u00a0randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy","volume":"70","author":"Fallon","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.amjmed.2013.02.014_bib5","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.cct.2012.08.009","article-title":"Antibiotic retreatment of Lyme disease in patients with persistent symptoms: a biostatistical review of randomized, placebo-controlled, clinical trials","volume":"33","author":"Delong","year":"2012","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.amjmed.2013.02.014_bib6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2147\/IJGM.S23829","article-title":"Benefit of intravenous antibiotic therapy in patients referred for treatment of neurologic Lyme disease","volume":"4","author":"Stricker","year":"2011","journal-title":"Intl J Gen Med"},{"issue":"Suppl 1-M2","key":"10.1016\/j.amjmed.2013.02.014_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/1874205X01206010079","article-title":"A\u00a0reappraisal of the U.S. clinical trials of post-treatment Lyme disease syndrome","volume":"6","author":"Fallon","year":"2012","journal-title":"Open Neurol J"},{"key":"10.1016\/j.amjmed.2013.02.014_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0002-9343(03)00308-5","article-title":"Long-term follow-up of patients with culture-confirmed Lyme disease","volume":"115","author":"Nowakowski","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2013.02.014_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.amjmed.2009.05.011","article-title":"Subjective symptoms after treatment of early Lyme disease","volume":"123","author":"Cerar","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2013.02.014_bib10","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJMra072023","article-title":"A\u00a0critical appraisal of \u201cchronic Lyme disease.\u201d","volume":"357","author":"Feder","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjmed.2013.02.014_bib11","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/art.24314","article-title":"Role of psychiatric comorbidity in chronic Lyme disease","volume":"59","author":"Hassett","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.amjmed.2013.02.014_bib12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.amjmed.2009.02.022","article-title":"Psychiatric comorbidity and other psychological factors in patients with \u201cchronic Lyme disease\u201d","volume":"122","author":"Hassett","year":"2009","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2013.02.014_bib13","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1212\/WNL.45.11.1956","article-title":"Fatigue therapy in multiple sclerosis: results of a double blind, randomized, parallel trial of amantadine, pemoline, and placebo","volume":"45","author":"Krupp","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.amjmed.2013.02.014_bib14","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(02)07882-0","article-title":"Sample size slippages in randomized trials: exclusions and the lost and wayward","volume":"359","author":"Schulz","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.amjmed.2013.02.014_bib15","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S1474-4422(08)70119-4","article-title":"Oral doxycycline versus intravenous ceftriaxone for European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blind, randomised trial","volume":"7","author":"Ljostad","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.amjmed.2013.02.014_bib16","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S1474-4422(08)70120-0","article-title":"Oral doxycycline for neuroborreliosis","volume":"7","author":"Wormser","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.amjmed.2013.02.014_bib17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","article-title":"The clinical evolution of Lyme arthritis","volume":"107","author":"Steere","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2013.02.014_bib18","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/508667","article-title":"The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"43","author":"Wormser","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.amjmed.2013.02.014_bib19","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1056\/NEJMoa1114362","article-title":"Differentiation of reinfection from relapse in recurrent Lyme disease","volume":"367","author":"Nadelman","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjmed.2013.02.014_bib20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/CMR.00004-09","article-title":"Antibiotic treatment of animals infected with Borrelia burgdorferi","volume":"22","author":"Wormser","year":"2009","journal-title":"Clin Microbiol Rev"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934313002015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934313002015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:00:36Z","timestamp":1757581236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934313002015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0002934313002015"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2013.02.014","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment Trials for Post-Lyme Disease Symptoms Revisited","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2013.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}