{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:51:57Z","timestamp":1784735517109,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.amjmed.2016.02.013","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T23:45:16Z","timestamp":1457480716000},"page":"746-752.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Methylprednisolone-Induced Lymphocytosis in Patients with Immune-Mediated Inflammatory Disorders"],"prefix":"10.1016","volume":"129","author":[{"given":"Laura","family":"Bromberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Roufosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pradier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-7028","authenticated-orcid":false,"given":"C\u00e9dric","family":"Delporte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Van Antwerpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"De Maertelaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Cogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.amjmed.2016.02.013_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory action of glucocorticoids\u2013new mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.amjmed.2016.02.013_bib2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.7326\/0003-4819-84-3-304","article-title":"Glucocorticosteroid therapy: Mechanisms of action and clinical considerations","volume":"84","author":"Fauci","year":"1976","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.amjmed.2016.02.013_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI107914","article-title":"Alternate-day prednisone therapy and human lymphocyte subpopulations","volume":"55","author":"Fauci","year":"1975","journal-title":"J\u00a0Clin Invest"},{"issue":"12","key":"10.1016\/j.amjmed.2016.02.013_bib4","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1136\/jcp.46.12.1089","article-title":"Effects of single dose compared with three days' prednisolone treatment of healthy volunteers: Contrasting effects on circulating lymphocyte subsets","volume":"46","author":"Pountain","year":"1993","journal-title":"J\u00a0Clin Pathol"},{"issue":"9","key":"10.1016\/j.amjmed.2016.02.013_bib5","doi-asserted-by":"crossref","first-page":"e24345","DOI":"10.1371\/journal.pone.0024345","article-title":"Influence of short-term glucocorticoid therapy on regulatory T cells in\u00a0vivo","volume":"6","author":"Sbiera","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.amjmed.2016.02.013_bib6","first-page":"342","article-title":"Prednisone versus deflazacort in the treatment of autoimmune thrombocytopenic purpura: Evaluation of clinical response and immunological modifications","volume":"76","author":"Ferrari","year":"1991","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.amjmed.2016.02.013_bib7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/ard.52.10.730","article-title":"Circulating T\u00a0cell subtypes in polymyalgia rheumatica and giant cell arteritis: Variation in the percentage of CD8+ cells with prednisolone treatment","volume":"52","author":"Pountain","year":"1993","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.amjmed.2016.02.013_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.hoc.2012.01.001","article-title":"Why does my patient have leukocytosis?","volume":"26","author":"Cerny","year":"2012","journal-title":"Hematol Oncol Clin North Am"},{"issue":"1","key":"10.1016\/j.amjmed.2016.02.013_bib9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jchromb.2007.09.003","article-title":"Simultaneous determination of cortisol, dexamethasone, methylprednisolone, prednisone, prednisolone, mycophenolic acid and mycophenolic acid glucuronide in human plasma utilizing liquid chromatography-tandem mass spectrometry","volume":"859","author":"Difrancesco","year":"2007","journal-title":"J\u00a0Chromatogr B\u00a0Analyt Technol Biomed Life Sci"},{"issue":"2","key":"10.1016\/j.amjmed.2016.02.013_bib10","first-page":"292","article-title":"The effects of prednisolone in leucocyte function in man. A double blind controlled study","volume":"28","author":"Clarke","year":"1977","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"10.1016\/j.amjmed.2016.02.013_bib11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1172\/JCI108982","article-title":"The differential effect of in\u00a0vivo hydrocortisone on the kinetics of subpopulations of human peripheral blood thymus-derived lymphocytes","volume":"61","author":"Haynes","year":"1978","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.amjmed.2016.02.013_bib12","first-page":"669","article-title":"Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and B lymphocytes to the bone marrow","volume":"28","author":"Fauci","year":"1975","journal-title":"Immunology"},{"key":"10.1016\/j.amjmed.2016.02.013_bib13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1210\/jcem-6-4-312","article-title":"Differential blood counts in certain adrenal cortical disorders (Cushing's syndrome, Addison's disease and panhypopituitarism)","volume":"6","author":"De La Balze","year":"1946","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"330","key":"10.1016\/j.amjmed.2016.02.013_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1136\/pgmj.29.330.200","article-title":"Addison's disease","volume":"29","author":"Smart","year":"1953","journal-title":"Postgrad Med J"},{"issue":"5","key":"10.1016\/j.amjmed.2016.02.013_bib15","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0002-9343(67)90103-9","article-title":"Addison's disease presenting as a lymphocyte dyscrasia","volume":"42","author":"Saphir","year":"1967","journal-title":"Am J Med"},{"issue":"12","key":"10.1016\/j.amjmed.2016.02.013_bib16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2169\/internalmedicine.33.733","article-title":"Circadian variations and prednisolone-induced alterations of circulating lymphocyte subsets in man","volume":"33","author":"Fukuda","year":"1994","journal-title":"Intern Med"},{"issue":"6380","key":"10.1016\/j.amjmed.2016.02.013_bib17","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1136\/bmj.286.6380.1773","article-title":"Circadian variation of lymphocyte subpopulations: A study with monoclonal antibodies","volume":"286","author":"Ritchie","year":"1983","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"8","key":"10.1016\/j.amjmed.2016.02.013_bib18","first-page":"712","article-title":"Transient atypical lymphocytosis in patients with emergency medical conditions","volume":"111","author":"Teggatz","year":"1987","journal-title":"Arch Pathol Lab Med"},{"issue":"3","key":"10.1016\/j.amjmed.2016.02.013_bib19","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/jcem-51-3-599","article-title":"Corticosteroid-induced differential regulation of beta-adrenergic receptors in circulating human polymorphonuclear leukocytes and mononuclear leukocytes","volume":"51","author":"Davies","year":"1980","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.amjmed.2016.02.013_bib20","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1365-2265.1994.tb02511.x","article-title":"Reduced lymphocyte beta 2-adrenoceptor density and impaired diastolic left ventricular function in patients with glucocorticoid deficiency","volume":"40","author":"Allolio","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"10.1016\/j.amjmed.2016.02.013_bib21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1183\/09031936.96.09010160","article-title":"Interactions of glucocorticoids and beta 2-agonists","volume":"9","author":"Adcock","year":"1996","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.amjmed.2016.02.013_bib22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1365-2249.1990.tb03310.x","article-title":"The influence of prednisolone on the recirculation of peripheral blood lymphocytes in\u00a0vivo","volume":"80","author":"Bloemena","year":"1990","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1016\/j.amjmed.2016.02.013_bib23","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1172\/JCI107591","article-title":"Human lymphocyte subpopulations. Effect of corticosteroids","volume":"53","author":"Yu","year":"1974","journal-title":"J\u00a0Clin Invest"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934316302017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934316302017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:08:44Z","timestamp":1757581724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934316302017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0002934316302017"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2016.02.013","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylprednisolone-Induced Lymphocytosis in Patients with Immune-Mediated Inflammatory Disorders","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2016.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}