{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:01:29Z","timestamp":1788318089279,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.amjmed.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T18:55:45Z","timestamp":1464202545000},"page":"1100-1109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mitral Valve Prolapse, Psychoemotional Status, and Quality of Life: Prospective Investigation in the Current Era"],"prefix":"10.1016","volume":"129","author":[{"given":"Tali","family":"Bayer-Topilsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh M.","family":"Suri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Topilsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yariv N.","family":"Marmor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max R.","family":"Trenerry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Antiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartzell V.","family":"Schaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Enriquez-Sarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2016.05.004_bib1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1176\/ajp.135.2.246","article-title":"Mitral valve prolapse syndrome and anxiety neurosis\/panic disorder","volume":"135","author":"Pariser","year":"1978","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.amjmed.2016.05.004_bib2","first-page":"38","article-title":"Does the association between mitral valve prolapse and panic disorder really exist?","volume":"10","author":"Filho","year":"2008","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"10.1016\/j.amjmed.2016.05.004_bib3","first-page":"255","article-title":"Time to dispel the mitral valve\/anxiety link","volume":"59","author":"Perez","year":"2010","journal-title":"J\u00a0Fam Pract"},{"key":"10.1016\/j.amjmed.2016.05.004_bib4","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.amjmed.2013.05.013","article-title":"Psycho-emotional manifestations of valvular heart diseases: prospective assessment in mitral regurgitation","volume":"126","author":"Bayer-Topilsky","year":"2013","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2016.05.004_bib5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.amjmed.2016.05.004_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199907013410101","article-title":"Prevalence and clinical outcome of mitral-valve prolapse","volume":"341","author":"Freed","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.amjmed.2016.05.004_bib7","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/0002-8703(89)90594-2","article-title":"Mitral valve prolapse and the mitral valve prolapse syndrome: a diagnostic classification and pathogenesis of symptoms","volume":"118","author":"Boudoulas","year":"1989","journal-title":"Am Heart J"},{"key":"10.1016\/j.amjmed.2016.05.004_bib8","series-title":"Diagnostic and Statistical Manual of Mental Disorders","first-page":"265","article-title":"Trauma and stressor-related disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.amjmed.2016.05.004_bib9","series-title":"Braunwald's Heart Disease. A Textbook of Cardiovascular Medicine","first-page":"1446","article-title":"Valvular heart disease","author":"Otto","year":"2015"},{"key":"10.1016\/j.amjmed.2016.05.004_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00006842-198803000-00001","article-title":"Mitral valve prolapse and panic disorder: a review of their relationship","volume":"50","author":"Margraf","year":"1988","journal-title":"Psychosom Med"},{"key":"10.1016\/j.amjmed.2016.05.004_bib11","first-page":"89","article-title":"Anxiety and mood disorder in young males with mitral valve prolapse","volume":"1","author":"Lung","year":"2008","journal-title":"J\u00a0Multidiscip Healthc"},{"key":"10.1016\/j.amjmed.2016.05.004_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1192\/bjp.bp.111.091934","article-title":"Mitral valve prolapse and anxiety disorders","volume":"199","author":"Filho","year":"2011","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.amjmed.2016.05.004_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11920-005-0077-5","article-title":"Anxiety and medical disorders","volume":"7","author":"Muller","year":"2005","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.amjmed.2016.05.004_bib14","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.athoracsur.2014.10.030","article-title":"Psychoemotional and quality of life response to mitral operations in patients with mitral regurgitation: a prospective study","volume":"99","author":"Bayer-Topilsky","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.amjmed.2016.05.004_bib15","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.amjmed.2016.05.004_bib16","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/01.CIR.80.3.589","article-title":"Three-dimensional echocardiographic reconstruction of the mitral valve, with implications for the diagnosis of mitral valve prolapse","volume":"80","author":"Levine","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2016.05.004_bib17","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0735-1097(98)90059-6","article-title":"Reconsideration of echocardiographic standards for mitral valve prolapse: lack of association between leaflet displacement isolated to the apical four chamber view and independent echocardiographic evidence of abnormality","volume":"11","author":"Levine","year":"1988","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2016.05.004_bib18","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/01.CIR.75.4.756","article-title":"The relationship of mitral annular shape to the diagnosis of mitral valve prolapse","volume":"75","author":"Levine","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2016.05.004_bib19","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.87.3.841","article-title":"Quantitative Doppler assessment of valvular regurgitation","volume":"87","author":"Enriquez-Sarano","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2016.05.004_bib20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0735-1097(94)00434-R","article-title":"Effective mitral regurgitant orifice area: clinical use and pitfalls of the proximal isovelocity surface area method","volume":"25","author":"Enriquez-Sarano","year":"1995","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.amjmed.2016.05.004_bib21","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.amjmed.2016.05.004_bib22","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.4088\/JCP.v64n1012","article-title":"Trajectories of posttraumatic stress disorder following myocardial infarction: a prospective study","volume":"64","author":"Ginzburg","year":"2003","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1016\/j.amjmed.2016.05.004_bib23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.amjmed.2016.05.004_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-3999(96)00216-4","article-title":"International experiences with the Hospital Anxiety and Depression Scale\u2014a review of validation data and clinical results","volume":"42","author":"Herrmann","year":"1997","journal-title":"J\u00a0Psychosom Res"},{"key":"10.1016\/j.amjmed.2016.05.004_bib25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1023\/A:1024719104351","article-title":"Validation of the PTSD Checklist-Civilian Version in survivors of bone marrow transplantation","volume":"12","author":"Smith","year":"1999","journal-title":"J\u00a0Trauma Stress"},{"key":"10.1016\/j.amjmed.2016.05.004_bib26","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/pon.1601","article-title":"Posttraumatic stress disorder symptoms in cancer: psychometric analysis of the Spanish Posttraumatic Stress Disorder Checklist-Civilian version","volume":"19","author":"Costa-Requena","year":"2010","journal-title":"Psychooncology"},{"key":"10.1016\/j.amjmed.2016.05.004_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1023\/A:1024490718043","article-title":"Factors associated with PTSD symptoms following treatment for breast cancer: test of the Andersen model","volume":"11","author":"Andrykowski","year":"1998","journal-title":"J\u00a0Trauma Stress"},{"key":"10.1016\/j.amjmed.2016.05.004_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/hrt.2003.013995","article-title":"Comparison of the short form (SF)-12 health status instrument with the SF-36 in patients with coronary heart disease","volume":"90","author":"Muller-Nordhorn","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.amjmed.2016.05.004_bib29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4065\/77.4.367","article-title":"Assessing clinical significance in measuring oncology patient quality of life: introduction to the symposium, content overview, and definition of terms","volume":"77","author":"Sloan","year":"2002","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjmed.2016.05.004_bib30","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.athoracsur.2011.11.062","article-title":"Quality of life after early mitral valve repair using conventional and robotic approaches","volume":"93","author":"Suri","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.amjmed.2016.05.004_bib31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.7326\/0003-4819-149-11-200812020-00003","article-title":"Sex differences in morphology and outcomes of mitral\u00a0valve prolapse","volume":"149","author":"Avierinos","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjmed.2016.05.004_bib32","first-page":"226","article-title":"Assessment of autonomic dysfunction and anxiety levels in patients with mitral valve prolapse","volume":"37","author":"Orhan","year":"2009","journal-title":"Turk Kardiyol Dern Ars"},{"key":"10.1016\/j.amjmed.2016.05.004_bib33","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(09)60692-9","article-title":"Mitral regurgitation","volume":"373","author":"Enriquez-Sarano","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.amjmed.2016.05.004_bib34","first-page":"227","article-title":"Mental health and post traumatic growth in civilians exposed to ongoing terror","volume":"18","author":"Bayer-Topilsky","year":"2013","journal-title":"J\u00a0Loss Trauma"},{"key":"10.1016\/j.amjmed.2016.05.004_bib35","first-page":"81","article-title":"The utility of Criterion A under chronic national terror","volume":"50","author":"Bensimon","year":"2013","journal-title":"Isr J Psychiatry Relat Sci"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934316304880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934316304880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:10:45Z","timestamp":1757581845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934316304880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0002934316304880"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2016.05.004","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitral Valve Prolapse, Psychoemotional Status, and Quality of Life: Prospective Investigation in the Current Era","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}