{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:00:22Z","timestamp":1790420422290,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.amjmed.2018.04.037","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T05:48:12Z","timestamp":1527313692000},"page":"1095-1103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Arterial Ischemic Events Are a Major Complication in Cancer Patients with Venous Thromboembolism"],"prefix":"10.1016","volume":"131","author":[{"given":"Benjamin","family":"Brenner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Tzoran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Madridano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"L\u00f3pez-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Suri\u00f1ach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"Blanco-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Tufano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9 L\u00f3pez","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Trujillo-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-0767","authenticated-orcid":false,"given":"Manuel","family":"Monreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.amjmed.2018.04.037_bib0001","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1160\/TH04-08-0506","article-title":"Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California in 1996","volume":"93","author":"White","year":"2005","journal-title":"Thromb Haemost"},{"issue":"11","key":"10.1016\/j.amjmed.2018.04.037_bib0002","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1001\/archinte.162.11.1245","article-title":"Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study","volume":"162","author":"Heit","year":"2002","journal-title":"Arch Intern Med."},{"issue":"6","key":"10.1016\/j.amjmed.2018.04.037_bib0003","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1470-2045(05)70207-2","article-title":"Cancer and venous thromboembolism","volume":"6","author":"Prandoni","year":"2005","journal-title":"Lancet Oncol."},{"issue":"10","key":"10.1016\/j.amjmed.2018.04.037_bib0004","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1111\/jth.13792","article-title":"Circulating tumor cell count and thrombosis in metastatic breast cancer","volume":"15","author":"Beinse","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1016\/j.amjmed.2018.04.037_bib0005","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00280-017-3386-6","article-title":"Risk of venous and arterial thromboembolic events associated with VEGFR-TKIs: a meta-analysis","volume":"80","author":"Liu","year":"2017","journal-title":"Cancer Chemother Pharmacol."},{"issue":"7","key":"10.1016\/j.amjmed.2018.04.037_bib0006","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/14737140.2017.1330153","article-title":"Increased risk of arterial thromboembolic events with combination lenalidomide\/dexamethasone therapy for multiple myeloma","volume":"17","author":"Maharaj","year":"2017","journal-title":"Expert Rev Anticancer Ther"},{"issue":"21","key":"10.1016\/j.amjmed.2018.04.037_bib0007","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1001\/archinte.168.21.2377","article-title":"Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer","volume":"168","author":"Khorana","year":"2008","journal-title":"Arch Intern Med."},{"issue":"3","key":"10.1016\/j.amjmed.2018.04.037_bib0008","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1200\/JCO.2005.03.8877","article-title":"Thromboembolism in hospitalized neutropenic cancer patients","volume":"24","author":"Khorana","year":"2006","journal-title":"J Clin Oncol."},{"issue":"2","key":"10.1016\/j.amjmed.2018.04.037_bib0009","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.radonc.2011.06.016","article-title":"Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden","volume":"100","author":"McGale","year":"2011","journal-title":"Radiother Oncol."},{"issue":"9","key":"10.1016\/j.amjmed.2018.04.037_bib0010","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/bjc.2011.361","article-title":"Increase in stroke risk in patients with head and neck cancer: a retrospective cohort study","volume":"105","author":"Chu","year":"2011","journal-title":"Br J Cancer"},{"issue":"8","key":"10.1016\/j.amjmed.2018.04.037_bib0011","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jacc.2017.06.047","article-title":"Risk of arterial thromboembolism in patients with cancer","volume":"70","author":"Navi","year":"2017","journal-title":"J Am Coll Cardiol."},{"issue":"suppl 2","key":"10.1016\/j.amjmed.2018.04.037_bib0012","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/S0049-3848(10)70015-3","article-title":"Bleeding complications associated with anticoagulant therapy in patients with cancer","volume":"125","author":"Trujillo-Santos","year":"2010","journal-title":"Thromb Res."},{"key":"10.1016\/j.amjmed.2018.04.037_bib0013","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.critrevonc.2017.03.006","article-title":"Venous thromboembolism in radiation therapy cancer patients: Findings from the RIETE registry","volume":"113","author":"Guy","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"issue":"suppl 1","key":"10.1016\/j.amjmed.2018.04.037_bib0014","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/S0049-3848(17)30061-0","article-title":"Gender differences in patients with venous thromboembolism and five common sites of cancer","volume":"151","author":"Martin-Martos","year":"2017","journal-title":"Thromb Res."},{"issue":"3","key":"10.1016\/j.amjmed.2018.04.037_bib0015","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.chest.2016.10.025","article-title":"Development of a risk prediction score for occult cancer in patients with VTE","volume":"151","author":"Jara-Palomares","year":"2017","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.amjmed.2018.04.037_bib0016","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1160\/TH17-07-0511","article-title":"Rationale, Design and Meth\nodology of the Computerized Registry of Patients with Venous Thromboembolism (RIETE)","volume":"118","author":"Bikdeli","year":"2018","journal-title":"Thromb Haemost"},{"issue":"25 Pt B","key":"10.1016\/j.amjmed.2018.04.037_bib0017","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.jacc.2013.11.005","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Goff","year":"2014","journal-title":"J Am Coll Cardiol."},{"issue":"3","key":"10.1016\/j.amjmed.2018.04.037_bib0018","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-0034-1370770","article-title":"Risk assessment for thrombosis in cancer","volume":"40","author":"Gomes","year":"2014","journal-title":"Semin Thromb Hemost"},{"issue":"36","key":"10.1016\/j.amjmed.2018.04.037_bib0019","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","article-title":"2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)","volume":"37","author":"Zamorano","year":"2016","journal-title":"Eur Heart J."},{"issue":"12","key":"10.1016\/j.amjmed.2018.04.037_bib0020","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1161\/STR.0000000000000046","article-title":"Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Meschia","year":"2014","journal-title":"Stroke"},{"issue":"13","key":"10.1016\/j.amjmed.2018.04.037_bib0021","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIR.0000000000000381","article-title":"Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science: A Scientific Statement From the American Heart Association","volume":"133","author":"McSweeney","year":"2016","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.amjmed.2018.04.037_bib0022","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.ejca.2012.01.005","article-title":"Risk of haemorrhagic and ischaemic stroke in patients with cancer: a nationwide follow-up study from Sweden","volume":"48","author":"Zoller","year":"2012","journal-title":"Eur J Cancer"},{"issue":"11","key":"10.1016\/j.amjmed.2018.04.037_bib0023","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.exphem.2015.07.004","article-title":"Disease dynamics in patients with acute myeloid leukemia: new biomarkers","volume":"43","author":"Tzoran","year":"2015","journal-title":"Exp Hematol."},{"issue":"9","key":"10.1016\/j.amjmed.2018.04.037_bib0024","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/j.1538-7836.2011.04418.x","article-title":"CD11b+ leukocyte microparticles are associated with high-risk angiographic lesions and recurrent cardiovascular events in acute coronary syndromes","volume":"9","author":"Faille","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1016\/j.amjmed.2018.04.037_bib0025","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.thromres.2014.07.006","article-title":"Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients","volume":"134","author":"Nadir","year":"2014","journal-title":"Thromb Res."},{"issue":"2","key":"10.1016\/j.amjmed.2018.04.037_bib0026","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMp030086","article-title":"Cancer-associated thrombosis","volume":"349","author":"Bick","year":"2003","journal-title":"N Engl J Med."},{"issue":"2","key":"10.1016\/j.amjmed.2018.04.037_bib0027","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.clineuro.2005.03.008","article-title":"Incidence of ischemic stroke post-chemotherapy: a retrospective review of 10,963 patients","volume":"108","author":"Li","year":"2006","journal-title":"Clin Neurol Neurosurg"},{"issue":"suppl 1","key":"10.1016\/j.amjmed.2018.04.037_bib0028","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.thromres.2018.01.003","article-title":"Arterial thrombosis and cancer","volume":"164","author":"Aronson","year":"2018","journal-title":"Thromb Res."},{"key":"10.1016\/j.amjmed.2018.04.037_bib0029","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.117.032617","article-title":"Risk and prognosis of cancer after lower limb arterial thrombosis","author":"Sundboll","year":"2018","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.amjmed.2018.04.037_bib0030","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S1470-2045(09)70232-3","article-title":"Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double-blind study","volume":"10","author":"Agnelli","year":"2009","journal-title":"Lancet Oncol."},{"issue":"10","key":"10.1016\/j.amjmed.2018.04.037_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(16)30369-2","article-title":"International clinical practice guidelines including guidance for direct oral anticoagulants in the treatment and prophylaxis of venous thromboembolism in patients with cancer","volume":"17","author":"Farge","year":"2016","journal-title":"Lancet Oncol."},{"issue":"6","key":"10.1016\/j.amjmed.2018.04.037_bib0032","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/cam4.1054","article-title":"Thromboembolic and bleeding complications during oral anticoagulation therapy in cancer patients with atrial fibrillation: a Danish nationwide population-based cohort study","volume":"6","author":"Ording","year":"2017","journal-title":"Cancer Med."}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934318304418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934318304418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:14:21Z","timestamp":1757582061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934318304418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0002934318304418"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2018.04.037","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arterial Ischemic Events Are a Major Complication in Cancer Patients with Venous Thromboembolism","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2018.04.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}