{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:57:30Z","timestamp":1772639850906,"version":"3.50.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.amjmed.2020.02.050","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T21:15:18Z","timestamp":1586380518000},"page":"1283-1286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multisystemic Involvement: Streptococcal Toxic Shock Syndrome"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-1770","authenticated-orcid":false,"given":"Diego","family":"Fernandez-Nieto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-507X","authenticated-orcid":false,"given":"Patricia","family":"Burgos-Blasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-0147","authenticated-orcid":false,"given":"Juan","family":"Jimenez-Cauhe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4990-1075","authenticated-orcid":false,"given":"Daniel","family":"Ortega-Quijano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Taboada-Illan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Bea-Ardebol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.amjmed.2020.02.050_bib0001","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJM198012183032501","article-title":"Toxic-shock syndrome: epidemiologic features, recurrence, risk factors, and prevention","volume":"303","author":"Davis","year":"1980","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.amjmed.2020.02.050_bib0002","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jemermed.2017.12.048","article-title":"The evaluation and management of toxic shock syndrome in the emergency department: a review of the literature","volume":"54","author":"Gottlieb","year":"2018","journal-title":"J Emerg Med"},{"issue":"7-8","key":"10.1016\/j.amjmed.2020.02.050_bib0003","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1078\/1438-4221-00232","article-title":"Staphylococcal and streptococcal superantigens: molecular, biological and clinical aspects","volume":"292","author":"Alouf","year":"2003","journal-title":"Int J Med Microbiol"},{"issue":"5","key":"10.1016\/j.amjmed.2020.02.050_bib0004","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1473-3099(09)70066-0","article-title":"Gram-positive toxic shock syndromes","volume":"9","author":"Lappin","year":"2009","journal-title":"Lancet Infect Dis"},{"issue":"9","key":"10.1016\/j.amjmed.2020.02.050_bib0005","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.2165\/11634180-000000000-00000","article-title":"Invasive group a streptococcal disease: epidemiology, pathogenesis and management","volume":"72","author":"Steer","year":"2012","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.amjmed.2020.02.050_bib0006","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0891-5520(05)70324-X","article-title":"The toxic shock syndromes","volume":"10","author":"Stevens","year":"1996","journal-title":"Infect Dis Clin North Am"},{"issue":"1","key":"10.1016\/j.amjmed.2020.02.050_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM198907063210101","article-title":"Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A","volume":"321","author":"Stevens","year":"1989","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.amjmed.2020.02.050_bib0008","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1001\/jama.1981.03320070025019","article-title":"Clinical manifestations of toxic shock syndrome","volume":"246","author":"Chesney","year":"1981","journal-title":"JAMA"},{"issue":"Suppl 1","key":"10.1016\/j.amjmed.2020.02.050_bib0009","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/clinids\/11.Supplement_1.S1","article-title":"Clinical aspects and spectrum of illness of toxic shock syndrome: overview","volume":"11","author":"Chesney","year":"1989","journal-title":"Rev Infect Dis"},{"issue":"3","key":"10.1016\/j.amjmed.2020.02.050_bib0010","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/CCM.0000000000002255","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"45","author":"Rhodes","year":"2017","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.amjmed.2020.02.050_bib0011","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1086\/653116","article-title":"Getting under the skin: the immunopathogenesis of Streptococcus pyogenes deep tissue infections","volume":"51","author":"Johansson","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"24","key":"10.1016\/j.amjmed.2020.02.050_bib0012","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1001\/jama.1984.03350240045037","article-title":"Corticosteroid therapy for patients with toxic shock syndrome","volume":"252","author":"Todd","year":"1984","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.amjmed.2020.02.050_bib0013","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/SHK.0b013e3182429b38","article-title":"Biological and technical considerations regarding the removal of bacteriotoxins in sepsis with emphasis on toxic shock syndrome toxin 1","volume":"37","author":"Brummelhuis","year":"2012","journal-title":"Shock"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934320302643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934320302643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:20:32Z","timestamp":1757582432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934320302643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0002934320302643"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2020.02.050","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multisystemic Involvement: Streptococcal Toxic Shock Syndrome","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2020.02.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}