{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:20:10Z","timestamp":1773926410634,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.amjmed.2020.08.035","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T21:21:12Z","timestamp":1601328072000},"page":"507-513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["LDL Cholesterol and Ischemic Stroke in Patients with Nonvalvular Atrial Fibrillation"],"prefix":"10.1016","volume":"134","author":[{"given":"Alexander","family":"Omelchenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzipi","family":"Hornik-Lurie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Gabay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saar","family":"Minha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid","family":"Assali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pereg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2020.08.035_bib0001","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2016.03.016","article-title":"Total cholesterol as a risk factor for coronary heart disease and stroke in women compared with men: a systematic review and meta-analysis","volume":"248","author":"Peters","year":"2016","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.amjmed.2020.08.035_bib0002","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1161\/STROKEAHA.117.019653","article-title":"Role of blood lipids in the development of ischemic stroke and its subtypes: a Mendelian randomization study","volume":"49","author":"Hindy","year":"2018","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.amjmed.2020.08.035_bib0003","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/STROKEAHA.111.641324","article-title":"Lipid and lipoprotein biomarkers and the risk of ischemic stroke in postmenopausal women","volume":"43","author":"Berger","year":"2012","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.amjmed.2020.08.035_bib0004","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa1910355","article-title":"A comparison of two LDL cholesterol targets after ischemic stroke","volume":"382","author":"Amarenco","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjmed.2020.08.035_bib0005","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.atherosclerosis.2016.03.024","article-title":"Cholesterol-lowering interventions and stroke: insights from IMPROVE-IT","volume":"248","author":"De Caterina","year":"2016","journal-title":"Atherosclerosis"},{"issue":"15","key":"10.1016\/j.amjmed.2020.08.035_bib0006","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1136\/heartjnl-2019-314763","article-title":"Proprotein convertase subtilisin\/kexin 9 inhibitors in reducing cardiovascular outcomes: a systematic review and meta-analysis","volume":"105","author":"Du","year":"2019","journal-title":"Heart"},{"issue":"12","key":"10.1016\/j.amjmed.2020.08.035_bib0007","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1161\/STR.0000000000000046","article-title":"Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Meschia","year":"2014","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.amjmed.2020.08.035_bib0008","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.amjmed.2020.08.035_bib0009","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.amjcard.2016.12.031","article-title":"Relation of low-density lipoprotein cholesterol to ischemic stroke in patients with nonvalvular atrial fibrillation","volume":"119","author":"Qi","year":"2017","journal-title":"Am J Cardiol"},{"issue":"7","key":"10.1016\/j.amjmed.2020.08.035_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201062","article-title":"Non-cardioembolic risk factors in atrial fibrillation-associated ischemic stroke","volume":"13","author":"Yang","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.amjmed.2020.08.035_bib0011","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1161\/STROKEAHA.110.602987","article-title":"Increases in cerebral atherosclerosis according to CHADS2 scores in patients with stroke with nonvalvular atrial fibrillation","volume":"42","author":"Kim","year":"2011","journal-title":"Stroke"},{"issue":"5-6","key":"10.1016\/j.amjmed.2020.08.035_bib0012","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000355571","article-title":"Is atrial fibrillation always a culprit of stroke in patients with atrial fibrillation plus stroke?","volume":"36","author":"Kim","year":"2013","journal-title":"Cerebrovasc Dis"},{"issue":"1","key":"10.1016\/j.amjmed.2020.08.035_bib0013","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000016023","article-title":"Cardioembolic vs. noncardioembolic strokes in atrial fibrillation: frequency and effect of antithrombotic agents in the stroke prevention in atrial fibrillation studies","volume":"10","author":"Hart","year":"2000","journal-title":"Cerebrovasc Dis"},{"issue":"4","key":"10.1016\/j.amjmed.2020.08.035_bib0014","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/0003319718791711","article-title":"Noncardioembolic stroke in patients with atrial fibrillation","volume":"70","author":"Katsi","year":"2019","journal-title":"Angiology"},{"issue":"6","key":"10.1016\/j.amjmed.2020.08.035_bib0015","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.clineuro.2007.03.009","article-title":"Atherothrombotic ischemic stroke in patients with atrial fibrillation","volume":"109","author":"Benbir","year":"2007","journal-title":"Clin Neurol Neurosurg"},{"issue":"14","key":"10.1016\/j.amjmed.2020.08.035_bib0016","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1056\/NEJMoa1709118","article-title":"Rivaroxaban with or without aspirin in stable cardiovascular disease","volume":"377","author":"Eikelboom","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.amjmed.2020.08.035_bib0017","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/jamaneurol.2019.2984","article-title":"Association between low-dose rivaroxaban with or without aspirin and ischemic stroke subtypes: a secondary analysis of the COMPASS Trial","volume":"77","author":"Perera","year":"2020","journal-title":"JAMA Neurol"},{"issue":"10117","key":"10.1016\/j.amjmed.2020.08.035_bib0018","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(17)32409-1","article-title":"Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial","volume":"391","author":"Anand","year":"2018","journal-title":"Lancet"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934320308172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934320308172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:25:13Z","timestamp":1757582713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934320308172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0002934320308172"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2020.08.035","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LDL Cholesterol and Ischemic Stroke in Patients with Nonvalvular Atrial Fibrillation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2020.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}