{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:28:27Z","timestamp":1792268907983,"version":"4.4.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.amjmed.2021.03.017","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T19:59:33Z","timestamp":1618948773000},"page":"1170-1174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pseudohyperchloremia and Negative Anion Gap \u2013 Think Salicylate!"],"prefix":"10.1016","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-3787","authenticated-orcid":false,"given":"Michael R.","family":"Wiederkehr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Raul","family":"Benevides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0186-4914","authenticated-orcid":false,"given":"Carol A.","family":"Santa Ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Emmett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.amjmed.2021.03.017_bib0001","doi-asserted-by":"crossref","first-page":"745","DOI":"10.7326\/0003-4819-85-6-745","article-title":"Unrecognized adult salicylate intoxication","volume":"85","author":"Anderson","year":"1976","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.amjmed.2021.03.017_bib0002","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archinte.1987.00370030114022","article-title":"A two-year review of salicylate deaths in Ontario","volume":"147","author":"McGuigan","year":"1987","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjmed.2021.03.017_bib0003","series-title":"Tietz Textbook of Clinical Chemistry and Molecular Diagnostics","first-page":"604","article-title":"Electrolytes and blood gases","author":"Schindler","year":"2018"},{"key":"10.1016\/j.amjmed.2021.03.017_bib0004","series-title":"Tietz Textbook of Clinical Chemistry and Molecular Diagnostics","first-page":"224","article-title":"Electrochemistry and chemical sensors","author":"D'Orazio","year":"2018"},{"issue":"8 Pt 1","key":"10.1016\/j.amjmed.2021.03.017_bib0005","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/clinchem\/36.8.1399","article-title":"Hyperchloremia and the incidence of bromism in 1990","volume":"36","author":"Bowers","year":"1990","journal-title":"Clin Chem"},{"issue":"10","key":"10.1016\/j.amjmed.2021.03.017_bib0006","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1177\/0883073819847862","article-title":"Potassium bromide in the treatment of pediatric refractory epilepsy","volume":"34","author":"Kodama","year":"2019","journal-title":"J Child Neurol"},{"issue":"8","key":"10.1016\/j.amjmed.2021.03.017_bib0007","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/jama.1990.03440080099031","article-title":"Bromide intoxication secondary to pyridostigmine bromide therapy","volume":"263","author":"Rothenberg","year":"1990","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.amjmed.2021.03.017_bib0008","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.ajem.2019.158491","article-title":"Bromism: an overlooked and elusive toxidrome from chronic dextromethorphan abuse","volume":"38","author":"Monks","year":"2020","journal-title":"Am J Emerg Med"},{"issue":"3","key":"10.1016\/j.amjmed.2021.03.017_bib0009","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF03161228","article-title":"Case files of the medical toxicology fellowship at the New York City Poison Control: bromism: forgotten, but not gone","volume":"5","author":"Lugassy","year":"2009","journal-title":"J Med Toxicol"},{"issue":"1","key":"10.1016\/j.amjmed.2021.03.017_bib0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1053\/j.ajkd.2015.07.024","article-title":"Approach to the patient with a negative anion gap","volume":"67","author":"Emmett","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"26","key":"10.1016\/j.amjmed.2021.03.017_bib0011","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMra2010852","article-title":"Salicylate toxicity","volume":"382","author":"Palmer","year":"2020","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.amjmed.2021.03.017_bib0012","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.annemergmed.2011.02.023","article-title":"Falsely normal anion gap in severe salicylate poisoning caused by laboratory interference","volume":"58","author":"Jacob","year":"2011","journal-title":"Ann Emerg Med"},{"issue":"10","key":"10.1016\/j.amjmed.2021.03.017_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajem.2013.05.031","article-title":"Negative anion gap metabolic acidosis in salicylate overdose\u2013a zebra!","volume":"31","author":"Kaul","year":"2013","journal-title":"Am J Emerg Med"},{"issue":"7","key":"10.1016\/j.amjmed.2021.03.017_bib0014","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/clinchem\/43.7.1249","article-title":"Salicylate interference with the Roche Cobas Integra chloride electrode","volume":"43","author":"Mori","year":"1997","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.amjmed.2021.03.017_bib0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/ndtplus\/sfr117","article-title":"Where is the gap?","volume":"5","author":"Riethm\u00fcller","year":"2012","journal-title":"Clin Kidney J"},{"issue":"7","key":"10.1016\/j.amjmed.2021.03.017_bib0016","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.ajem.2015.12.038","article-title":"Salicylate toxicity in the absence of anion gap metabolic acidosis","volume":"34","author":"Bauer","year":"2016","journal-title":"Am J Emerg Med"},{"issue":"11","key":"10.1016\/j.amjmed.2021.03.017_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajem.2015.03.042","article-title":"Normal anion gap salicylate poisoning","volume":"33","author":"Wright","year":"2015","journal-title":"Am J Emerg Med"},{"issue":"3","key":"10.1016\/j.amjmed.2021.03.017_bib0018","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000484636","article-title":"Spurious hyperchloremia in the presence of elevated plasma salicylate: a cohort study","volume":"138","author":"Kashani","year":"2018","journal-title":"Nephron"},{"issue":"2","key":"10.1016\/j.amjmed.2021.03.017_bib0019","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1053\/j.ajkd.2007.11.017","article-title":"Salicylate intoxication as a cause of pseudohyperchloremia","volume":"51","author":"Zimmer","year":"2008","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1016\/j.amjmed.2021.03.017_bib0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ajem.2013.11.033","article-title":"Negative anion gap metabolic acidosis and low level of salicylate cannot ignore salicylate toxicity!","volume":"32","author":"Srivali","year":"2014","journal-title":"Am J Emerg Med"},{"issue":"6","key":"10.1016\/j.amjmed.2021.03.017_bib0021","first-page":"525","article-title":"Non-anion gap acidosis in significant salicylate poisoning: mind the non-gap!","volume":"56","author":"Harmouche","year":"2018","journal-title":"Clin Toxicol"},{"issue":"4","key":"10.1016\/j.amjmed.2021.03.017_bib0022","doi-asserted-by":"crossref","first-page":"A33","DOI":"10.1053\/j.ajkd.2015.02.076","article-title":"Acute salicylate intoxication as a cause of low serum anion gap and pseudohyperchloremia","volume":"65","author":"El Kour","year":"2015","journal-title":"Am J Kidney Dis"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934321002308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934321002308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:25:10Z","timestamp":1757582710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934321002308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0002934321002308"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2021.03.017","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pseudohyperchloremia and Negative Anion Gap \u2013 Think Salicylate!","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2021.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}