{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:23:11Z","timestamp":1787779391789,"version":"build-2784847793"},"reference-count":16,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.amjmed.2026.04.018","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:11:11Z","timestamp":1776467471000},"page":"1305-1310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["New understanding and treatment of adult mitochondrial dysfunction: an example of personalized precision medicine"],"prefix":"10.1016","volume":"139","author":[{"given":"Gabriela R.","family":"Esnaola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-5371","authenticated-orcid":false,"given":"Edward J.","family":"Goetzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2026.04.018_bib0001","doi-asserted-by":"crossref","DOI":"10.1126\/science.ady5532","article-title":"Mitochondrial control of fuel switching via carnitine biosynthesis","volume":"391","author":"Auger","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102784","article-title":"Genetics of mitochondrial diseases: identifying mutations to help diagnosis","volume":"56","author":"Stenton","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.600079","article-title":"The dimensions of primary mitochondrial disorders","volume":"8","author":"Schlieben","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0004","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41392-024-02044-3","article-title":"Mitochondrial diseases: from molecular mechanisms to therapeutic advances","volume":"10","author":"Wen","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0005","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1474-4422(21)00098-3","article-title":"Mitochondrial disease in adults: recent advances and future promise","volume":"20","author":"Ng","year":"2021","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0006","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12929-023-00975-7","article-title":"Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis","volume":"30","author":"Liu","year":"2023","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0007","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adw7376","article-title":"The PP2A-B55alpha phosphatase is a master regulator of mitochondrial degradation and biogenesis","volume":"11","author":"Cianfanelli","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0008","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/cells12010020","article-title":"Mitochondrial unfolded protein response and integrated stress response as promising therapeutic targets for Mitochondrial diseases","volume":"12","author":"Lu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0009","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-3-319-95046-4_31","article-title":"Mitochondrial disorder: maternally inherited diabetes and deafness","volume":"1085","author":"Tsang","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0010","article-title":"Germline genetic variants in pheochromocytoma\/paraganglioma: single-center experience","volume":"3","author":"Lima","year":"2023","journal-title":"Endocr Oncol"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0011","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1530\/ERC-15-0208","article-title":"Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval","volume":"22","author":"Aissani","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0012","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads1842","article-title":"Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging","volume":"11","author":"Bubb","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26030944","article-title":"Elamipretide: a review of its structure, mechanism of action, and therapeutic potential","volume":"26","author":"Tung","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0014","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aea8481","article-title":"Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase","volume":"11","author":"Hu","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0015","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo3724","article-title":"Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes","volume":"14","author":"Jacoby","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.amjmed.2026.04.018_bib0016","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adt1318","article-title":"Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine","volume":"11","author":"Lou","year":"2025","journal-title":"Sci Adv"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934326002883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934326002883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:09:23Z","timestamp":1787778563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934326002883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0002934326002883"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2026.04.018","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New understanding and treatment of adult mitochondrial dysfunction: an example of personalized precision medicine","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2026.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}