{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:28:39Z","timestamp":1793651319442,"version":"4.5.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01HX003757"],"award-info":[{"award-number":["1I01HX003757"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01HX002422"],"award-info":[{"award-number":["I01HX002422"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01HX003552"],"award-info":[{"award-number":["1I01HX003552"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL156518"],"award-info":[{"award-number":["1R01HL156518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AG073474"],"award-info":[{"award-number":["1R01AG073474"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RF1AG069121"],"award-info":[{"award-number":["1RF1AG069121"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.amjmed.2026.06.049","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:08:46Z","timestamp":1792285726000},"page":"1672-1682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Echocardiographic estimates of pulmonary artery acceleration time and mortality risk in older adults"],"prefix":"10.1016","volume":"139","author":[{"given":"Joel Anthony","family":"Nations","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-5678","authenticated-orcid":false,"given":"Federico E.","family":"Mordini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Khosla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip H.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Frishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbert S.","family":"Aronow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibadete","family":"Byty\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louay","family":"Aldabain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyfaa","family":"Mashaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charity J.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Heidenreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-8093","authenticated-orcid":false,"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjmed.2026.06.049_bib0001","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/0002-9149(87)91189-1","article-title":"Evaluation of pulmonary artery pressure and resistance by pulsed Doppler echocardiography","volume":"59","author":"Dabestani","year":"1987","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0002","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/01.CIR.68.2.302","article-title":"Noninvasive evaluation of pulmonary hypertension by a pulsed doppler technique","volume":"68","author":"Kitabatake","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0003","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.echo.2017.10.016","article-title":"Pulmonary hypertension and Pulmonary artery acceleration time: a systematic review and meta\u2013analysis","volume":"31","author":"Wang","year":"2018","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0004","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13089-022-00276-4","article-title":"Pulmonary artery acceleration time accuracy for systolic pulmonary artery pressure estimation in critically ill patients","volume":"14","author":"Dammassa","year":"2022","journal-title":"Ultrasound J"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1164\/rccm.202306-0990ED","article-title":"Illuminating the importance of pulmonary arterial compliance in pulmonary hypertension","volume":"208","author":"Weatherald","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"issue":"702","key":"10.1016\/j.amjmed.2026.06.049_bib0006","doi-asserted-by":"crossref","first-page":"702.e7","DOI":"10.1016\/j.amjmed.2017.12.046","article-title":"Diabetes mellitus associates with increased right ventricular afterload and remodeling in pulmonary arterial hypertension","volume":"131","author":"Whitaker","year":"2018","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0007","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0002-9149(86)90627-2","article-title":"Comparison of Doppler\u2013determined elevated pulmonary arterial pressure with pressure measured at cardiac catheterization","volume":"57","author":"Martin\u2013Duran","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0008","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.echo.2016.08.013","article-title":"Pulmonary artery acceleration time provides a reliable estimate of invasive Pulmonary hemodynamics in children","volume":"29","author":"Levy","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0009","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1053\/j.jvca.2025.01.028","article-title":"Examining the relationship between pulmonary artery acceleration time and pulmonary artery pressures in patients with ischemic cardiogenic shock","volume":"39","author":"Lashin","year":"2025","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0010","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1053\/j.jvca.2015.04.004","article-title":"Pulmonary artery acceleration time in cardiac surgical patients","volume":"29","author":"Tousignant","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0011","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70383","article-title":"Proximal pulmonary artery stiffening as a biomarker of cardiopulmonary aging","volume":"25","author":"De Man","year":"2026","journal-title":"Aging Cell"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0012","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1055\/s-0030-1265894","article-title":"The pulmonary circulation and exercise responses in the elderly","volume":"31","author":"Taylor","year":"2010","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0013","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1183\/20734735.003416","article-title":"Pulmonary hypertension in the elderly: a different disease?","volume":"12","author":"Berra","year":"2016","journal-title":"Breathe"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0014","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/1047-2797(93)90062-9","article-title":"Recruitment of adults 65 years and older as participants in the cardiovascular health study","volume":"3","author":"Tell","year":"1993","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1047-2797(91)90005-W","article-title":"The cardiovascular health study: design and rationale","volume":"1","author":"Fried","year":"1991","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0016","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.amjcard.2010.09.019","article-title":"Natural history of concentric left ventricular geometry in community\u2013dwelling older adults without heart failure during seven years of follow\u2013up","volume":"107","author":"Desai","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0017","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jchf.2014.03.016","article-title":"Adverse left ventricular remodeling in community\u2013dwelling older adults predicts incident heart failure and mortality","volume":"2","author":"Zile","year":"2014","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajmo.2026.100129","article-title":"Risk of a dementia diagnosis in community\u2013dwelling older adults with normal MMSE scores in the United States","volume":"15","author":"Sin","year":"2026","journal-title":"Am J Med Open"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0019","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0894-7317(14)80105-3","article-title":"Echocardiographic design of a multicenter investigation of free\u2013living elderly subjects: the cardiovascular health study","volume":"5","author":"Gardin","year":"1992","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0020","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1161\/01.CIR.91.6.1739","article-title":"Sex, age, and disease affect echocardiographic left ventricular mass and systolic function in the free\u2013living elderly. The cardiovascular health study","volume":"91","author":"Gardin","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0021","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.115.004431","article-title":"Echocardiographic predictors of sudden cardiac death: the atherosclerosis risk in communities study and cardiovascular health study","volume":"9","author":"Konety","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0022","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.echo.2011.03.008","article-title":"Pulmonary artery acceleration time provides an accurate estimate of systolic pulmonary arterial pressure during transthoracic echocardiography","volume":"24","author":"Yared","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0023","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.amjmed.2010.06.018","article-title":"Pulmonary hypertension and long\u2013term mortality in aortic and mitral regurgitation","volume":"123","author":"Parker","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0024","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.amjmed.2015.11.026","article-title":"Pathophysiology of pulmonary hypertension in chronic parenchymal lung disease","volume":"129","author":"Singh","year":"2016","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0025","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.amjmed.2017.05.003","article-title":"Pulmonary hypertension with left heart disease: prevalence, temporal shifts in etiologies and outcome","volume":"130","author":"Weitsman","year":"2017","journal-title":"Am J Med"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0026","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/CIRCULATIONAHA.115.020207","article-title":"Association of borderline pulmonary hypertension with mortality and hospitalization in a large patient cohort: insights from the veterans affairs clinical assessment, reporting, and tracking program","volume":"133","author":"Maron","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.amjmed.2026.06.049_bib0027","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur Respir J"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934326005371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934326005371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:55:50Z","timestamp":1793649350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934326005371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0002934326005371"],"URL":"https:\/\/doi.org\/10.1016\/j.amjmed.2026.06.049","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Echocardiographic estimates of pulmonary artery acceleration time and mortality risk in older adults","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjmed.2026.06.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}