{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:04:33Z","timestamp":1774958673137,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.amjms.2017.03.024","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T20:31:32Z","timestamp":1489696292000},"page":"533-538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Kidney Diseases Associated With Alternative Complement Pathway Dysregulation and Potential Treatment Options"],"prefix":"10.1016","volume":"354","author":[{"given":"Prateek","family":"Sanghera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mythili","family":"Ghanta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Ozay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesh K.","family":"Ariyamuthu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2378-9302","authenticated-orcid":false,"given":"Bekir","family":"Tanriover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.amjms.2017.03.024_bib1","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.2215\/CJN.01710216","article-title":"All things complement","volume":"11","author":"Thurman","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"issue":"12","key":"10.1016\/j.amjms.2017.03.024_bib2","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1681\/ASN.2015020184","article-title":"Kidney disease caused by dysregulation of the complement alternative pathway: an etiologic approach","volume":"26","author":"De Vriese","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.amjms.2017.03.024_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/imr.12477","article-title":"The complement factor H-related proteins","volume":"274","author":"Medjeral-Thomas","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.amjms.2017.03.024_bib4","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1182\/asheducation-2015.1.644","article-title":"Syndromes of thrombotic microangiopathy associated with pregnancy","volume":"2015","author":"George","year":"2015","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"4","key":"10.1016\/j.amjms.2017.03.024_bib5","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.kint.2016.04.018","article-title":"Targeting the complement cascade: novel treatments coming down the pike","volume":"90","author":"Thurman","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjms.2017.03.024_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/asheducation-2011.1.15","article-title":"Atypical hemolytic uremic syndrome, genetic basis, and clinical manifestations","volume":"2011","author":"Kavanagh","year":"2011","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"1","key":"10.1016\/j.amjms.2017.03.024_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molimm.2015.03.246","article-title":"Atypical aHUS: state of the art","volume":"67","author":"Nester","year":"2015","journal-title":"Mol Immunol"},{"issue":"11","key":"10.1016\/j.amjms.2017.03.024_bib8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nrneph.2012.213","article-title":"Pathogenesis of the C3 glomerulopathies and reclassification of MPGN","volume":"8","author":"Bomback","year":"2012","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"10.1016\/j.amjms.2017.03.024_bib9","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/ki.2015.60","article-title":"Managing atypical hemolytic uremic syndrome: chapter 2","volume":"87","author":"Nester","year":"2015","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.amjms.2017.03.024_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.hoc.2013.02.006","article-title":"Thrombotic thrombocytopenic purpura and the atypical hemolytic uremic syndrome: an update","volume":"27","author":"Tsai","year":"2013","journal-title":"Hematol Oncol Clin North Am"},{"issue":"Suppl 17","key":"10.1016\/j.amjms.2017.03.024_bib11","first-page":"1","article-title":"Atypical hemolytic uremic syndrome (aHUS): making the diagnosis","volume":"10","author":"Laurence","year":"2012","journal-title":"Clin Adv Hematol Oncol"},{"issue":"6","key":"10.1016\/j.amjms.2017.03.024_bib12","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1111\/j.1600-6143.2012.03991.x","article-title":"Postpartum aHUS secondary to a genetic abnormality in factor H acquired through liver transplantation","volume":"12","author":"Brown","year":"2012","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.amjms.2017.03.024_bib13","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1097\/TXD.0000000000000555","article-title":"Characteristics and outcomes of renal transplant recipients with hemolytic uremic syndrome in the United States","volume":"1","author":"Tanriover","year":"2015","journal-title":"Transplant Direct"},{"issue":"11","key":"10.1016\/j.amjms.2017.03.024_bib14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneph.2012.214","article-title":"French Study Group for a HCG Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies","volume":"8","author":"Zuber","year":"2012","journal-title":"Nat Rev Nephrol"},{"issue":"23","key":"10.1016\/j.amjms.2017.03.024_bib15","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1056\/NEJMoa1208981","article-title":"Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome","volume":"368","author":"Legendre","year":"2013","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.amjms.2017.03.024_bib16","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1056\/NEJMoa1311084","article-title":"Genetic variants in C5 and poor response to eculizumab","volume":"370","author":"Nishimura","year":"2014","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.amjms.2017.03.024_bib17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.trre.2013.07.003","article-title":"Targeted strategies in the prevention and management of atypical HUS recurrence after kidney transplantation","volume":"27","author":"Zuber","year":"2013","journal-title":"Transplant Rev (Orlando)"},{"issue":"1","key":"10.1016\/j.amjms.2017.03.024_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2215\/CJN.03480708","article-title":"Dense deposit disease: clinicopathologic study of 32 pediatric and adult patients","volume":"4","author":"Nasr","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.amjms.2017.03.024_bib19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/MNH.0b013e32835da24c","article-title":"Treatment options for C3 glomerulopathy","volume":"22","author":"Nester","year":"2013","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"5","key":"10.1016\/j.amjms.2017.03.024_bib20","doi-asserted-by":"crossref","first-page":"748","DOI":"10.2215\/CJN.12901211","article-title":"Eculizumab for dense deposit disease and C3 glomerulonephritis","volume":"7","author":"Bomback","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"issue":"8","key":"10.1016\/j.amjms.2017.03.024_bib21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.imbio.2015.04.001","article-title":"Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy","volume":"220","author":"Zhang","year":"2015","journal-title":"Immunobiology"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000296291730160X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000296291730160X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:35:17Z","timestamp":1757702117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000296291730160X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S000296291730160X"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2017.03.024","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kidney Diseases Associated With Alternative Complement Pathway Dysregulation and Potential Treatment Options","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2017.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Southern Society for Clinical Investigation. Published by All rights reserved.","name":"copyright","label":"Copyright"}]}}