{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:39:48Z","timestamp":1780317588649,"version":"3.54.1"},"reference-count":14,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","amjmedsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.amjms.2017.03.027","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T18:45:46Z","timestamp":1490208346000},"page":"3-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cannabinoids and Symptomatic Bradycardia"],"prefix":"10.1016","volume":"355","author":[{"given":"Mark R.","family":"Heckle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mannu","family":"Nayyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl T.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjms.2017.03.027_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-5793(95)01207-U","article-title":"The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling","volume":"375","author":"Bayewitch","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.amjms.2017.03.027_bib2","unstructured":"United States Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. Drug Abuse Warning Network (DAWN), 2011. ICPSR34565-v3. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor]. http:\/\/doi.org\/10.3886\/ICPSR34565.v3. November 23, 2015."},{"issue":"168","key":"10.1016\/j.amjms.2017.03.027_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/3-540-26573-2_23","article-title":"Pharmacokinetics and metabolism of the plant cannabinoids, \u03949-tetrahydrocannabinol, cannabidiol and cannabinol","author":"Huestis","year":"2005","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.amjms.2017.03.027_bib4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00007611-198103000-00035","article-title":"Marijuana and second-degree AV block","volume":"74","author":"Akins","year":"1981","journal-title":"South Med J"},{"key":"10.1016\/j.amjms.2017.03.027_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/MAJ.0b013e31812f5105","article-title":"Exercise-induced asystole with syncope in a healthy young man","volume":"334","author":"Dockery","year":"2007","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.amjms.2017.03.027_bib6","first-page":"489","article-title":"Effects of prolonged administration of delta 9-tetrahydrocannabinol on the autonomic and cardiovascular function and regional hemodynamics in mongrel dogs","volume":"20","author":"Jandhyala","year":"1978","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.amjms.2017.03.027_bib7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/cpt1975183287","article-title":"Cardiovascular effects of prolonged delta-9-tetrahydrocannabinol ingestion","volume":"18","author":"Benowitz","year":"1975","journal-title":"Clin Pharmacol Ther"},{"issue":"suppl 8-9","key":"10.1016\/j.amjms.2017.03.027_bib8","doi-asserted-by":"crossref","first-page":"214S","DOI":"10.1002\/j.1552-4604.1981.tb02598.x","article-title":"Cardiovascular and metabolic considerations in prolonged cannabinoid administration in man","volume":"21","author":"Benowitz","year":"1981","journal-title":"J Clin Pharmacol"},{"issue":"suppl 11","key":"10.1016\/j.amjms.2017.03.027_bib9","doi-asserted-by":"crossref","first-page":"58S","DOI":"10.1002\/j.1552-4604.2002.tb06004.x","article-title":"Cardiovascular system effects of marijuana","volume":"42","author":"Jones","year":"2002","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.amjms.2017.03.027_bib10","first-page":"659","article-title":"Effects of cannabinoids on the perfused rat heart","volume":"14","author":"Smiley","year":"1976","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.amjms.2017.03.027_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3181\/00379727-180-42181","article-title":"Effects and interactions of natural cannabinoids on the isolated heart","volume":"180","author":"Nahas","year":"1985","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.amjms.2017.03.027_bib12","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0022-3565(24)36714-X","article-title":"Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors","volume":"281","author":"Lake","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.amjms.2017.03.027_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0361-9230(87)90087-6","article-title":"D9-Tetrahydrocannabinol: EEG changes, bradycardia and hypothermia in the rhesus monkey","volume":"19","author":"Matsuzaki","year":"1987","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.amjms.2017.03.027_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-3565(24)39125-6","article-title":"Cannabinoids cause central sympathoexcitation and bradycardia in rabbits","volume":"294","author":"Niederhoffer","year":"2000","journal-title":"J Pharmacol Exp Ther"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962917301660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962917301660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T16:05:13Z","timestamp":1750176313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962917301660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0002962917301660"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2017.03.027","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoids and Symptomatic Bradycardia","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2017.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Southern Society for Clinical Investigation. Published by All rights reserved.","name":"copyright","label":"Copyright"}]}}