{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:19:31Z","timestamp":1778901571114,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","amjmedsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.amjms.2017.03.031","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T07:02:12Z","timestamp":1491462132000},"page":"22-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma Antiphospholipid Antibodies Effects on Activated Partial Thromboplastin Time Assays"],"prefix":"10.1016","volume":"354","author":[{"given":"Ke","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengju","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjms.2017.03.031_bib1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0049-3848(97)00265-X","article-title":"Longer aPTT values in healthy children than in adults: no single cause","volume":"88","author":"Gallistl","year":"1997","journal-title":"Thromb Res"},{"key":"10.1016\/j.amjms.2017.03.031_bib2","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4065\/82.7.864","article-title":"How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults","volume":"82","author":"Kamal","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjms.2017.03.031_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0002-9343(90)90458-P","article-title":"Correlation between lupus anticoagulants and anticardiolipin antibodies in patients with prolonged activated partial thromboplastin times","volume":"88","author":"Alving","year":"1990","journal-title":"Am J Med"},{"key":"10.1016\/j.amjms.2017.03.031_bib4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.imbio.2005.10.012","article-title":"Antiphospholipid antibodies in pediatric patients with prolonged activated partial thromboplastin time during infection","volume":"210","author":"Frauenknecht","year":"2005","journal-title":"Immunobiology"},{"key":"10.1016\/j.amjms.2017.03.031_bib5","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1182\/blood-2002-02-0441","article-title":"Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature","volume":"101","author":"Galli","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.amjms.2017.03.031_bib6","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.thromres.2006.06.003","article-title":"A functional coagulation test to identify anti-\u03b22-glycoprotein I dependent lupus anticoagulants","volume":"119","author":"Devreese","year":"2007","journal-title":"Thromb Res"},{"key":"10.1016\/j.amjms.2017.03.031_bib7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/PAT.0000000000000142","article-title":"Antiphospholipid antibody testing for the antiphospholipid syndrome: a comprehensive practical review including a synopsis of challenges and recent guidelines","volume":"46","author":"Favaloro","year":"2014","journal-title":"Pathology"},{"key":"10.1016\/j.amjms.2017.03.031_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0140-6736(93)91477-4","article-title":"The antiphospholipid syndrome: ten years on","volume":"342","author":"Hughes","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.amjms.2017.03.031_bib9","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/0140-6736(90)91374-J","article-title":"Anticardiolipinantibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor","volume":"334","author":"Galli","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.amjms.2017.03.031_bib10","series-title":"Hughes Syndrome: Antiphospholipid Syndrome","first-page":"214","article-title":"Lupus anticoagulant measurement","author":"Mackie","year":"2000"},{"key":"10.1016\/j.amjms.2017.03.031_bib11","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","article-title":"Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis","volume":"7","author":"Pengo","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.amjms.2017.03.031_bib12","first-page":"2760","article-title":"Research of the efficiency of different lupus anticoagulant assays","volume":"95","author":"Shou","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.amjms.2017.03.031_bib13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1055\/s-0032-1311991","article-title":"Laboratory identification of lupus anticoagulants","volume":"38","author":"Kershaw","year":"2012","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.amjms.2017.03.031_bib14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-0032-1311993","article-title":"Internal quality control and external quality assurance in testing for antiphospholipid antibodies: Part II\u2014lupus anticoagulant","volume":"38","author":"Favaloro","year":"2012","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.amjms.2017.03.031_bib15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.amjmed.2007.10.025","article-title":"Activated partial thromboplastin time and risk of future venous thromboembolism","volume":"121","author":"Zakai","year":"2008","journal-title":"Am J Med"},{"key":"10.1016\/j.amjms.2017.03.031_bib16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1538-7836.2004.00712.x","article-title":"A two-step coagulation test to identify antibeta-glycoprotein I lupus anticoagulants","volume":"2","author":"Pengo","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.amjms.2017.03.031_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.amjms.2017.03.031_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1538-7836.2009.03674.x","article-title":"Clinical course of high-risk patients diagnosed with antiphospholipid syndrome","volume":"8","author":"Pengo","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.amjms.2017.03.031_bib19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.thromres.2004.06.031","article-title":"Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies","volume":"114","author":"Pierangeli","year":"2004","journal-title":"Thromb Res"},{"key":"10.1016\/j.amjms.2017.03.031_bib20","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.4049\/jimmunol.153.3.1328","article-title":"Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies","volume":"153","author":"Kornberg","year":"1994","journal-title":"J Immunol"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962917301982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962917301982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T01:05:14Z","timestamp":1692752714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962917301982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0002962917301982"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2017.03.031","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma Antiphospholipid Antibodies Effects on Activated Partial Thromboplastin Time Assays","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2017.03.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Southern Society for Clinical Investigation. Published by All rights reserved.","name":"copyright","label":"Copyright"}]}}